Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose cartridge and permit a user to set the delivery dose. The injector may include a housing, a cartridge containing medicinal product, the cartridge being retained within the housing, means for selecting a dose of medicinal product to be expelled, and means for expelling the selected dose of medicinal product. The housing may be a unitary housing within which the means for selecting a dose and the means for expelling the selected dose are moveably retained. Alternatively, the injector may include a housing, a piston rod, an insert located in the housing and through which the piston may rotate, a ratchet, a dose dial sleeve, a drive sleeve, a button located on the drive sleeve and rotatable with respect to the drive sleeve, and a clutch which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve.

Abstract: Injection devices are known for the self administration of a medicament by patients in which the medicament is contained within a cartridge located within the injection device. It is a problem that such injection devices should be small enough to fit into a jacket pocket or a hand bag without difficulty. Concurrently, the injection device must be of size that enables a piston or similar used to drive a cartridge bung within the cartridge to be moved both to a maximum dispense position within the cartridge and to be fully withdrawn from the cartridge to allow for replacement of the cartridge.

Abstract: A pen-type injector is improved so that a user may select a delivery dose of medicinal product from a multidose cartridge. The injector includes a housing. a cartridge containing medicinal product retained within a housing, a piston rod, a dose selecting member to select a dose of medicinal product to be expelled, and a drive member to expel the selected dose of medicinal product. The housing is formed unitary so that the dose selecting member and the drive member are moveably retained within the housing. The injector may include ratchet means associated with the insert to ensure the piston rod only rotates in a single direction through the insert, a button located on the drive sleeve, and clutch means which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve.

Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose cartridge and permit a user to set the delivery dose. The injector may include a housing, a cartridge containing medicinal product, the cartridge being retained within the housing, means for selecting a dose of medicinal product to be expelled, and means for expelling the selected dose of medicinal product. The housing may be a unitary housing within which the means for selecting a dose and the means for expelling the selected dose are moveably retained. Alternatively, the injector may include a housing, a piston rod, an insert located in the housing and through which the piston may rotate, ratchet means, a dose dial sleeve, a drive sleeve, a button located on the drive sleeve and rotatable with respect to the drive sleeve, and clutch means which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve.

Abstract: Many of those having diabetes take a combination of slow and fast acting types of insulin. It is important that the different forms of medicament do not become confused. To this end, a medicament cartridge is provided comprising a sleeve having a bottleneck providing a flange at a first end, a fluid impermeable membrane secured across the first end by a metal cap beaded beneath the flange, and a displaceable piston located internally of the sleeve towards a second end of the sleeve, a collar located against an external periphery of the cartridge housing beneath the flange and an adaptor top press fit over the cap and the collar, the adaptor top being provided with means to act upon the collar thereby to retain the adaptor top on the sleeve.

Abstract: Injection devices are known for the self administration of medicament by patients in which the medicaments is typically contained within a cartridge located within the injection device. It is a problem that injection devices should be small enough to fit into a jacket pocket or a hand bag without difficulty. Also, the injection device must be of a size that enables a piston or similar used to drive a cartridge bung within the cartridge to be moved both to a maximum dispense position within the cartridge and to be fully withdrawn from the cartridge to allow for replacement of the cartridge.

Abstract: A drive mechanism for an injection device is disclosed in which piston means are selectively driven to expel medicament from within a medicament cartridge. The drive mechanism comprises a drive means associated with a first ratchet member, a second ratchet member associated with the piston means, a housing, the first ratchet member and the second ratchet member being disposed within the housing. The second ratchet member being biased by biasing means toward the first ratchet member. The drive means is actuable reciprocally to drive the first ratchet member in a first angular direction such that the first ratchet member drives the second ratchet member along its longitudinal axis against the biasing means along at least a part of its movement and subsequently drives the first ratchet member and the second ratchet member together in a second angular direction thereby to drive the piston means.

Abstract: The present invention relates to a medicament delivery device such as a pen type injector used to expel medicament from a medicament cartridge under the action of a lead screw. The medicament cartridge typically comprises a cylinder having a displaceable piston at one end displacement causing medicament contained within the cartridge to be expelled. It is of advantage to know when the plunger contacts the displaceable piston since no delivery of medicament can occur before this point.

Abstract: Many of those having diabetes take a combination of slow and fast acting types of insulin. It is important that the different forms of medicament do not become confused. To this end, a medicament cartridge is provided comprising a sleeve having a bottleneck providing a flange at a first end, a fluid impermeable membrane secured across the first end by a metal cap beaded beneath the flange, and a displaceable piston located internally of the sleeve towards a second end of the sleeve, a collar located against an external periphery of the cartridge housing beneath the flange and an adaptor top press fit over the cap and the collar, the adaptor top being provided with means to act upon the collar thereby to retain the adaptor top on the sleeve.

Abstract: The present disclosure is directed to a dose setting mechanism that may be used with a drug delivery device. The dose setting mechanism may include an inner body having a helical thread along an outer cylindrical surface of the inner body, and a drive sleeve for driving a piston rod in an axial direction, the drive sleeve positioned within at least a portion of the inner body. The dose setting mechanism may further include a dose dial sleeve rotatably engaged with the helical thread of the inner body and a dial grip connected to the dose dial sleeve and releasably connected to the drive sleeve. Further when a dose is set, the dial grip is rotated so that both the dose dial sleeve and the drive sleeve rotate with respect to the inner body.

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a piston rod, and a unidirectional coupling between the housing and the piston rod. The drive mechanism may also include a dose dial sleeve and a drive sleeve, with a clutch mean located therebetween to prevent relative rotation between the dial sleeve and the drive sleeve when in a coupled state and to permit relative rotation between the dial sleeve and the drive sleeve when in a de-coupled state.

Abstract: Many of those having diabetes take a combination of slow and fast acting types of insulin. It is important that the different forms of medicament do not become confused. To this end, a medicament cartridge is provided comprising a sleeve having a bottleneck providing a flange at a first end, a fluid impermeable membrane secured across the first end by a metal cap beaded beneath the flange, and a displaceable piston located internally of the sleeve towards a second end of the sleeve, a collar located against an external periphery of the cartridge housing beneath the flange and an adaptor top press fit over the cap and the collar, the adaptor top being provided with means to act upon the collar thereby to retain the adaptor top on the sleeve.

Abstract: The present invention relates to methods of influencing the flux or surface retention time of a topically active pharmaceutical ingredient through skin and formulations relating thereto.

Abstract: An airfoil for a gas turbine engine includes: opposed pressure and suction sidewalls extending between spaced-apart leading and trailing edges, a root, and a tip; and a hollow plenum disposed between the sidewalls. The plenum has a chordwise first dimension at a radially outer end thereof, and a chordwise second dimension at a radially inner end thereof. The second dimension is substantially less than the first dimension.

Abstract: A method for generating an internal pack coating having different, controlled thicknesses includes partially filling a root opening of a turbine blade having a cavity therein with a first powder and a second powder having different formulations so that the first powder contacts a first predefined portion of the surface of the cavity and the second powder contacts a second predefined portion of the surface of the cavity. The method further includes heating the object with the first powder and the second powder therein to thereby produce a coating of the internal cavity having different coating thicknesses over the first portion of the surface of the cavity and the second portion of the surface of the cavity.

Abstract: Injection devices are known for the self administration of medicament by patients in which medicament is typically contained within a cartridge located within the injection device. It is a problem that injection devices should be small enough to fit into a jacket pocket or a hand bag without difficulty. Also, the injection device must be of a size that enables a piston or similar used to drive a cartridge bung within the cartridge to be moved both to a maximum dispense position within the cartridge and to be fully withdrawn from the cartridge to allow for replacement of the cartridge.

Abstract: Many of those having diabetes take a combination of slow and fast acting types of insulin. It is important that the different forms of medicament do not become confused and that the patient does not receive the incorrect medicament. In combination a medicament delivery apparatus and a medicament cartridge are provided, the medicament delivery apparatus including at least one switch and the medicament cartridge comprising a cartridge housing within which a medicament is provided, a displaceable piston located internally at one end of the housing and a raised ring of material about an external periphery of the medicament cartridge, the ring of material being of sufficient dimensions, in use, to trip the at least one switch of the medicament delivery apparatus.

Abstract: An injection device for injection of a medicament from a medicament cartridge 40 having a neck portion is disclosed. The injection device further comprises a main housing 4 in which the medicament cartridge 40 is releasably retained by first and second retaining means 92,94. The retaining means 92,94 are each moveable between a first position in which the neck portion is engaged thereby to retain the medicament cartridge 40 in the main housing 4 and a second position which allows the medicament cartridge 40 to be removed from the main housing 4.

Abstract: A drive mechanism for an injection device is disclosed in which piston means 306 are selectively driven to expel medicament from within a medicament cartridge 40. A drive mechanism for controlling the movement of the piston means is described comprising a housing 302, a shuttle 300 located for movement within the housing 302 along a longitudinal axis between a first position and a second position, and drive means to move the shuttle 300 within the housing 302. A gear component 304 is located within the housing 302 for rotation about the longitudinal axis and associated with the piston means 306, movement of the shuttle 300 between each of the first and the second positions causing movement of the piston means 306.

Abstract: Injection devices are known for the self administration of medicament by patients. The medicament is typically contained within a cartridge located within the injection device. It is a problem that injection devices should be small enough to fit into a jacket pocket or a hand bag without difficulty. Also, the injection device must be of a size that enables a piston or similar used to drive the Cartridge bung within the cartridge to be moved both to a maximum dispense position within the cartridge and to be fully withdrawn from the cartridge to allow for replacement of the cartridge. A drive mechanism for an injecting device is disclosed in which the drive mechanism comprises a displaceable dosing spindle 6, a dial dose means 8, a transmission means 10, and a cable means 12, a piston comprising a plurality of nested piston members 30, 32, 34, displacement of the transmission means 10 causing the cable means 12 to move at least one of one of the nested piston members to drive a cartridge bung 18.