Patents by Inventor Nigel J. Clarke

Nigel J. Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHDOS FOR DETECTING ESTRADIOL BY MASS SPECTROMETRY
    Publication number: 20150309055
    Abstract: Provided are methods for determining the amount of estradiol in a sample using mass spectrometry. The methods generally involve ionizing estradiol in a sample and detecting and quantifying the amount of the ion to determine the amount of estradiol in the sample.
    Type: Application
    Filed: March 2, 2015
    Publication date: October 29, 2015
    Inventors: Mildred M. GOLDMAN, Nigel J. CLARKE, Richard E. REITZ
  • MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA
    Publication number: 20150276768
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Application
    Filed: June 15, 2015
    Publication date: October 1, 2015
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • Mass spectrometry assay for congenital adrenal hyperplasia
    Patent number: 9057732
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: June 16, 2015
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • Thyroglobulin quantitation by mass spectrometry
    Patent number: 9046531
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: June 2, 2015
    Assignee: Quest Diagnostics Investments Inc.
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E Reitz
  • Thyroglobulin quantitation by mass spectroscopy
    Patent number: 9012394
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: April 21, 2015
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Methods for detecting vitamin D metabolites by mass spectrometry
    Patent number: 8936943
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: January 20, 2015
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Methods for detecting estrone by mass spectrometry
    Patent number: 8916385
    Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: December 23, 2014
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: Mildred M. Goldman, Nigel J. Clarke, Richard E. Reitz
  • METHOD AND SYSTEM FOR DETERMINING A WADING DEPTH OF A VEHICLE
    Publication number: 20140371976
    Abstract: The present invention relates to a method of determining a wade depth (dMax) in relation to a vehicle (1) when at least partially submerged in water. An attitude of the vehicle (1) is determined and a first height (dSensed) of the surface of the water measured relative to a first reference point on the vehicle (1). The wade depth (dMax) is determined based on the attitude of the vehicle (1) and said first height (dSensed). Alternatively, or in addition, the travel height (HS) of a vehicle suspension is determined. Aspects of the invention also relates to a system and a vehicle (1).
    Type: Application
    Filed: February 14, 2013
    Publication date: December 18, 2014
    Applicant: Jagur Land Rover Limited
    Inventors: Simon Gilling, Thuy-Yung Tran, Edward Hoare, Nigel J. Clarke
  • Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
    Patent number: 8852951
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: October 7, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Anne Caston-Balderrama, Richard E Reitz
  • METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY
    Publication number: 20140234989
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 21, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Brett HOLMQUIST, Nigel J. CLARKE, Anne Caston-Balderrama, Richard E. Reitz
  • MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA
    Publication number: 20140175275
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Application
    Filed: February 26, 2014
    Publication date: June 26, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY
    Publication number: 20140162371
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Application
    Filed: February 14, 2014
    Publication date: June 12, 2014
    Applicant: Quest Diagnostics Investments Incoporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY
    Publication number: 20140093899
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Application
    Filed: September 19, 2013
    Publication date: April 3, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Mass spectrometry assay for congenital adrenal hyperplasia
    Patent number: 8674291
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: March 18, 2014
    Assignee: Quest Diagnostics Investments Inc.
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION
    Publication number: 20140051176
    Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Richard E Reitz
  • THYROGLOBULIN QUANTITATION BY MASS SPECTROMETRY
    Publication number: 20140038219
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Application
    Filed: October 14, 2013
    Publication date: February 6, 2014
    Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: YANNI ZHANG, NIGEL J. CLARKE, RICHARD E. REITZ
  • MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA
    Publication number: 20140014832
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Application
    Filed: September 13, 2013
    Publication date: January 16, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Amit GHOSHAL, Nigel J. CLARKE, Mildred M. GOLDMAN
  • Thyroglobulin quantitation by mass spectrometry
    Patent number: 8574915
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: November 5, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Methods for detecting dihydrotestosterone by mass spectrometry
    Patent number: 8563922
    Abstract: Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: October 22, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Richard E. Reitz, Amit Ghoshal
  • METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY
    Publication number: 20130236979
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Application
    Filed: April 26, 2013
    Publication date: September 12, 2013
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz