Patents by Inventor Nigel J. Clarke

Nigel J. Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY
    Publication number: 20130228680
    Abstract: Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.
    Type: Application
    Filed: March 29, 2013
    Publication date: September 5, 2013
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Richard E Reitz
  • Glucagon detection and quantitation by mass spectrometry
    Patent number: 8497079
    Abstract: Methods are described for measuring the amount of glucagon in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying glucagon in a sample.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: July 30, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke
  • Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
    Patent number: 8497471
    Abstract: Methods are described for measuring the amount of a methylation TPMT enzyme product in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying 6-MMP or isotopically labeled 6-MMP in a test sample utilizing mass spectrometric techniques and for using such methods to determine the activity of TPMT enzyme that is present in a sample.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: July 30, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: William F. Haddon, Nigel J. Clarke
  • METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY
    Publication number: 20130143329
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Application
    Filed: January 28, 2013
    Publication date: June 6, 2013
    Inventors: Brett Holmquist, Nigel J. Clarke, Anne Caston-Balderrama, Richard E. Reitz
  • Thyroglobulin quantitation by mass spectrometry
    Patent number: 8455259
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: June 4, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Mass spectrometry assay for congenital adrenal hyperplasia
    Patent number: 8415616
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: April 9, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • Methods for detecting dihydrotestosterone by mass spectrometry
    Patent number: 8410428
    Abstract: Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: April 2, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Richard Reitz
  • Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
    Patent number: 8389292
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: March 5, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Anne Caston-Balderrama, Richard E. Reitz
  • Mass spectrometry assay for plasma-renin
    Patent number: 8362417
    Abstract: Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1 ions are then related to the amount of angiotensin 1 generated in the sample, which in turn is related to renin activity in the sample.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: January 29, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Cory E. Bystrom, Richard E. Reitz, Nigel J. Clarke
  • GLUCAGON DETECTION AND QUANTITATION BY MASS SPECTROMETRY
    Publication number: 20130005050
    Abstract: Methods are described for measuring the amount of glucagon in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying glucagon in a sample.
    Type: Application
    Filed: December 20, 2010
    Publication date: January 3, 2013
    Inventors: Yanni Zhang, Nigel J. Clarke
  • Methods for detecting dehydroepiandrosterone by mass spectrometry
    Patent number: 8283627
    Abstract: Provided are methods for determining the amount of underivatized dehydroepiandrosterone (DHEA) in a sample using mass spectrometry. The methods generally involve ionizing DHEA in a sample and detecting and quantifying the amount of the ion to determine the amount of DHEA in the sample.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: October 9, 2012
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Richard E. Reitz
  • MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA
    Publication number: 20120228487
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Application
    Filed: March 9, 2012
    Publication date: September 13, 2012
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY
    Publication number: 20120190121
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Application
    Filed: March 30, 2012
    Publication date: July 26, 2012
    Inventors: Brett Holmquist, Nigel J. Clarke, Anne Caston-Balderrama, Richard E. Reitz
  • METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY
    Publication number: 20120175517
    Abstract: Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.
    Type: Application
    Filed: March 21, 2012
    Publication date: July 12, 2012
    Inventors: Amit Ghoshal, Nigel J. Clarke, Richard Reitz
  • Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
    Patent number: 8173442
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: May 8, 2012
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Anne Caston-Balderrama, Richard E. Reitz
  • Methods for detecting dihydrotestosterone by mass spectrometry
    Patent number: 8158931
    Abstract: Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: April 17, 2012
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Richard Reitz
  • MASS SPECTROMETRY ASSAY FOR PLASMA-RENIN
    Publication number: 20120088260
    Abstract: Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1 ions are then related to the amount of angiotensin 1 generated in the sample, which in turn is related to renin activity in the sample.
    Type: Application
    Filed: December 19, 2011
    Publication date: April 12, 2012
    Inventors: Cory E. Bystrom, Richard E. Reitz, Nigel J. Clarke
  • Mass spectrometry assay for congenital adrenal hyperplasia
    Patent number: 8153962
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: April 10, 2012
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • Mass spectrometry assay for plasma-renin
    Patent number: 8106351
    Abstract: Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1 ions are then related to the amount of angiotensin 1 generated in the sample, which in turn is related to renin activity in the sample.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: January 31, 2012
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Cory E. Bystrom, Richard E. Reitz, Nigel J. Clarke
  • THYROGLOBULIN QUANTITATION BY MASS SPECTROMETRY
    Publication number: 20120009614
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Application
    Filed: August 4, 2011
    Publication date: January 12, 2012
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz