Patents by Inventor Nigel J. Forrow

Nigel J. Forrow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mediator-stabilized reagent compositions for use in biosensor electrodes
    Patent number: 9714441
    Abstract: The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (PQ) and more especially transition metal complexes of PQ, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: July 25, 2017
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Nigel J. Forrow
  • Mediator-Stabilized Reagent Compositions for Use in Biosensor Electrodes
    Publication number: 20140216949
    Abstract: The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (PQ) and more especially transition metal complexes of PQ, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 7, 2014
    Applicant: Abbott Diabetes Care Inc.
    Inventor: Nigel J. Forrow
  • Mediator stabilized reagent compositions for use in biosensor electrodes
    Patent number: 8696884
    Abstract: The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (PQ) and more especially transition metal complexes of PQ, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: April 15, 2014
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Nigel J. Forrow
  • Biosensor electrode mediators for regeneration of cofactors
    Patent number: 8414760
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: April 9, 2013
    Assignee: Abbott Laboratories
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephen Walters
  • Biosensor Electrode Mediators for Regeneration of Cofactors
    Publication number: 20130031780
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Application
    Filed: July 30, 2012
    Publication date: February 7, 2013
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephen Walters
  • Biosensor Having Improved Hematocrit and Oxygen Biases
    Publication number: 20130001101
    Abstract: The present invention provides reagent compositions, and analyte measuring devices and methods that utilize the reagent compositions.
    Type: Application
    Filed: April 2, 2012
    Publication date: January 3, 2013
    Inventors: Nigel J. Forrow, Shridhara Alva Karinka
  • Mediator-Stabilized Reagent Compositions for Use in Biosensor Electrodes
    Publication number: 20120325679
    Abstract: The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (PQ) and more especially transition metal complexes of PQ, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium.
    Type: Application
    Filed: April 2, 2012
    Publication date: December 27, 2012
    Inventor: Nigel J. Forrow
  • Biosensor electrode mediators for regeneration of cofactors
    Patent number: 8241485
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: August 14, 2012
    Assignee: Abbott Laboratories
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephan Walters
  • Biosensor electrode mediators for regeneration of cofactors
    Patent number: 8221612
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: July 17, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephan Walters
  • Mediator stabilized reagent compositions for use in biosensor electrodes
    Patent number: 8163146
    Abstract: The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (PQ) and more especially transition metal complexes of PQ, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: April 24, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Nigel J. Forrow
  • Biosensor having improved hematocrit and oxygen biases
    Patent number: 8163160
    Abstract: The present invention provides reagent compositions, and analyte measuring devices and methods that utilize the reagent compositions.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: April 24, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Nigel J. Forrow, Shridhara Alva Karinka
  • Biosensor electrode mediators for regeneration of cofactors
    Patent number: 8012341
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: September 6, 2011
    Assignee: Abbott Laboratories
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephen Walters
  • Biosensor electrode mediators for regeneration of cofactors
    Patent number: 7998337
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: August 16, 2011
    Assignee: Abbott Laboratories
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephan Walters
  • Biosensor Having Improved Hematocrit and Oxygen Biases
    Publication number: 20110031133
    Abstract: The present invention provides reagent compositions, and analyte measuring devices and methods that utilize the reagent compositions.
    Type: Application
    Filed: June 14, 2010
    Publication date: February 10, 2011
    Inventors: Nigel J. Forrow, Shridhara Alva Karinka
  • Biosensor having improved hematocrit and oxygen biases
    Patent number: 7754093
    Abstract: The present invention provides reagent compositions, and analyte measuring devices and methods that utilize the reagent compositions.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: July 13, 2010
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Nigel J. Forrow, Shridhara Alva Karinka
  • BIOSENSOR ELECTRODE MEDIATORS FOR REGENERATION OF COFACTORS
    Publication number: 20090166223
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Application
    Filed: September 30, 2008
    Publication date: July 2, 2009
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephen Walters
  • Mediator-Stabilized Reagent Compositions for Use in Biosensor Electrodes
    Publication number: 20090095625
    Abstract: The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (PQ) and more especially transition metal complexes of PQ, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium.
    Type: Application
    Filed: October 12, 2007
    Publication date: April 16, 2009
    Inventor: Nigel J. Forrow
  • BIOSENSOR ELECTRODE MEDIATORS FOR REGENERATION OF COFACTORS
    Publication number: 20090090624
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD or NADP-dependent enzymes.
    Type: Application
    Filed: September 30, 2008
    Publication date: April 9, 2009
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephen Walters
  • BIOSENSOR ELECTRODE MEDIATORS FOR REGENERATION OF COFACTORS
    Publication number: 20090090625
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Application
    Filed: September 30, 2008
    Publication date: April 9, 2009
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephan Walters
  • Biosensor electrode mediators for regeneration of cofactors
    Patent number: 7504019
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: March 17, 2009
    Assignee: Abbott Laboratories
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephen Walters