Patents by Inventor Nigel J. Forrow

Nigel J. Forrow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosensor electrode mediators for regeneration of cofactors
    Publication number: 20040197935
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Application
    Filed: April 26, 2004
    Publication date: October 7, 2004
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephen Walters
  • Electrode with thin working layer
    Patent number: 6764581
    Abstract: Disclosed is an improved electrode for use in an electrochemical sensor for measuring an analyte in a sample. The electrode includes a thin working layer whose thickness is from 2 to 10 microns. Also disclosed is an electrode strip that includes an electrode with a thin working layer. Typically, the thin working layer includes an enzyme and a redox mediator. In an electrode for measuring glucose, the enzyme can be glucose oxidase and the redox mediator can be ferrocene.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: July 20, 2004
    Assignee: Abbott Laboratories
    Inventors: Nigel J. Forrow, Simon W. Bayliff
  • Biosensor electrode mediators for regeneration of cofactors and process for using
    Patent number: 6736957
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: May 18, 2004
    Assignee: Abbott Laboratories
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephen Walters