Patents by Inventor Nigel Ramsden

Nigel Ramsden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triazole derivatives as kinase inhibitors
    Patent number: 8883820
    Abstract: The invention relates to compounds of formula (I); wherein X and R1 to R5 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of Itk or PI3K, for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: November 11, 2014
    Assignee: Cellzome Ltd.
    Inventors: Francis Wilson, Nigel Ramsden, Kathryn Bell, Andrew Cansfield, Svenja Burckhardt, Jess Taylor, Mihiro Sunose, David Middlemiss
  • Pyrazolo[4,3-c]Pyridine Derivatives As Kinase Inhibitors
    Publication number: 20140323504
    Abstract: The present invention relates to compounds of formula (I) wherein X1 to X5, Y, ZA, ZB, R and A have the meaning as cited in the description and the claims. Said compounds are useful as kinase inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as the use as medicaments.
    Type: Application
    Filed: September 20, 2012
    Publication date: October 30, 2014
    Inventors: Claudio Dagostin, Nigel Ramsden
  • Amino triazoles as PI3K inhibitors
    Patent number: 8865699
    Abstract: The invention relates to compounds of formula (I) wherein X, T1 and R1 to R3 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of PI3K, for the treatment or prophylaxis of immunological, inflammatory, autoimmune, or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: October 21, 2014
    Assignee: Cellzome Ltd.
    Inventors: Nigel Ramsden, Kathryn Bell, Andrew David Cansfield, Jess Taylor, Mihiro Sunose, David Middlemiss, Gitte Neubauer
  • PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS
    Publication number: 20140296234
    Abstract: The invention relates to compounds of formula (I) wherein X, R1, R2, T, m, n, o have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: June 13, 2014
    Publication date: October 2, 2014
    Inventors: Rosemary LYNCH, Andrew David CANSFIELD, Helen Sarah NIBLOCK, Daniel HARDY, Jane Elizabeth SCANLON, Rita ADREGO, Nigel RAMSDEN
  • Pyrimidine derivatives as mTOR inhibitors
    Patent number: 8785457
    Abstract: The invention relates to compounds of formula (I) wherein X, R1, R2, T, m, n, o have the meaning as cited in the description and the claims. The compounds of formula (I) are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: July 22, 2014
    Assignee: Cellzome Limited
    Inventors: Rosemary Lynch, Andrew David Cansfield, Helen Sarah Niblock, Daniel Hardy, Jane Elizabeth Scanlon, Rita Adrego, Nigel Ramsden
  • Heterocyclyl Pyrimidine Analogues As JAK Inhibitors
    Publication number: 20140179664
    Abstract: The present invention relates to compounds of formula (I) wherein X1 to X5, Z1 to Z3, Y0, RY1, RY2 and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: July 24, 2012
    Publication date: June 26, 2014
    Applicant: Cellzome Limited
    Inventors: Jay Freeman, Valerie Reader, Glynn Addison, Nigel Ramsden, Jane Elizabeth Scanlon, Richard John Harrison
  • Methods for the Identification of Methyltransferase Interacting Molecules and for the Purification of Methyltransferase Proteins
    Publication number: 20130210664
    Abstract: The present invention relates to immobilization compounds, immobilization products and preparations thereof as well as methods and uses for the identification of methyltransferase interacting compounds or for the purification or identification of methyltransferase proteins.
    Type: Application
    Filed: August 4, 2011
    Publication date: August 15, 2013
    Applicant: Cellzome AG
    Inventors: John Harrison, Glynn Addison, Nigel Ramsden, Gerard Drewes
  • HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS SELECTIVE JAK INHIBITORS
    Publication number: 20130190292
    Abstract: The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: August 12, 2011
    Publication date: July 25, 2013
    Applicant: CELLZOME LIMITED
    Inventors: Kathryn Bell, Nelly Piton, Claudio Dagostin, Cyrille Boussard, Andrew Ratcliffe, Nigel Ramsden
  • TRIAZOLOPYRIDINES AS TYK2 INHIBITORS
    Publication number: 20130143915
    Abstract: The present invention relates to compounds of Formula (I), wherein R1 to R6 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immuno logically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.
    Type: Application
    Filed: June 28, 2011
    Publication date: June 6, 2013
    Applicant: CELLZOME LIMITED
    Inventors: Katie Ellard, Nigel Ramsden
  • PYRAZOLE COMPOUNDS AS JAK INHIBITORS
    Publication number: 20130131043
    Abstract: The invention relates to compounds of formula (I) wherein R1, R2, R1a, R1b have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: April 18, 2011
    Publication date: May 23, 2013
    Inventors: Richard John Harrison, Warren Miller, Sally Oxenford, Nigel Ramsden, Andrew Hobson
  • Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins
    Patent number: 8367830
    Abstract: The present invention relates to immobilization compounds of formula (I), immobilization products and preparations thereof as well as methods and uses for the identification of phosphatidylinositol kinase interacting compounds or for the purification or identification of phosphatidylinositol kinase proteins.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: February 5, 2013
    Assignee: Cellzome AG
    Inventors: Kathryn Bell, Nigel Ramsden, Giovanna Bergamini Moore, Gitte Neubauer
  • METHODS FOR THE IDENTIFICATION OF KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF KINASE PROTEINS
    Publication number: 20120270237
    Abstract: The present invention relates to immobilization compounds (I), immobilization products and preparations thereof as well as methods and uses for the identification of kinase interacting compounds or for the purification or identification of kinase proteins.
    Type: Application
    Filed: March 31, 2010
    Publication date: October 25, 2012
    Applicant: Cellzone AG
    Inventors: Nigel Ramsden, Jeremy Major, John Harrison, Daniel Leggate, Paola Grandi
  • HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS
    Publication number: 20120252779
    Abstract: The invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: October 19, 2010
    Publication date: October 4, 2012
    Inventors: Nigel Ramsden, Richard John Harrison, Sally Oxenford, Kathryn Bell, Nelly Piton, Claudio Dagostin, Cyrille Boussard, Andrew Ratcliffe
  • METHODS FOR THE IDENTIFICATION OF ZAP-70 INTERACTING MOLECULES AND FOR THE PURIFICATION OF ZAP-70
    Publication number: 20120178180
    Abstract: The invention provides in a first aspect a method for the identification of an ZAP-70 interacting compound, comprising the steps of a) providing a protein preparation containing phosphorylated ZAP-70, b) contacting the protein preparation with aminopyrido-pyrimidine ligand 24 immobilized on a solid support under conditions allowing the formation of an aminopyrido-pyrimidine ligand 24—phosphorylated ZAP-70 complex, c) incubating the aminopyrido-pyrimidine ligand 24—phosphorylated ZAP-70 complex with a given compound, and d) determining whether the compound is able to separate phosphorylated ZAP-70 from the immobilized aminopyrido-pyrimidine ligand 24.
    Type: Application
    Filed: June 1, 2007
    Publication date: July 12, 2012
    Inventors: Ulrich Kruse, Nigel Ramsden, Gerard Drewes, Dirk Eberhard
  • ORTHO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK INHIBITORS
    Publication number: 20120172385
    Abstract: The invention relates to compounds of formula (I) wherein X1 to X3, R, R2 to R7 and AA have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: September 7, 2010
    Publication date: July 5, 2012
    Inventors: Richard John Harrison, Andrew Hobson, Nigel Ramsden
  • PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS
    Publication number: 20120142667
    Abstract: The invention relates to compounds of formula (I) wherein R1 to R5, X and X1 to X3 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: June 10, 2010
    Publication date: June 7, 2012
    Inventors: Nigel Ramsden, Jeremy Major, Adeline Morel, Mihiro Sunose, Nelly Piton
  • METHODS FOR THE IDENTIFICATION OF PHOSPHATIDYLINOSITOL KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF PHOSPHATIDYLINOSITOL KINASE PROTEINS
    Publication number: 20120135421
    Abstract: The present invention relates to immobilization compounds of formula (I), immobilization products and preparations thereof as well as methods and uses for the identification of phosphatidylinositol kinase interacting compounds or for the purification or identification of phosphatidylinositol kinase proteins.
    Type: Application
    Filed: May 14, 2010
    Publication date: May 31, 2012
    Applicant: Cellzome AG
    Inventors: Kathryn Bell, Nigel Ramsden, Giovanva Bergamini Moore, Gitte Neubauer
  • Methods for the identification of PI3K interacting molecules and for the purification of PI3K
    Patent number: 8153389
    Abstract: The present invention relates to methods for the identification of a PI3K interacting compound using phenylthiazole ligand 1.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: April 10, 2012
    Assignee: CellZone AG
    Inventors: Giovanna Bergamini Moore, Andrew Cansfield, Nigel Ramsden, Gitte Neubauer
  • METHODS FOR THE IDENTIFICATION OF KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF KINASE PROTEINS
    Publication number: 20120083006
    Abstract: The present invention relates to immobilization compounds (I), immobilization products and preparations thereof as well as methods and uses for the identification of kinase interacting compounds or for the purification or identification of kinase proteins.
    Type: Application
    Filed: March 31, 2010
    Publication date: April 5, 2012
    Applicant: Cellzone AG
    Inventors: Nigel Ramsden, Jeremy Major, John Harrison, Daniel Leggate, Paola Grandi
  • PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
    Publication number: 20120065202
    Abstract: The invention relates to compounds of formula (I) wherein X, R1, R2, T, m, n, o have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
    Type: Application
    Filed: March 12, 2010
    Publication date: March 15, 2012
    Inventors: Rosemary Lynch, Andrew David Cansfield, Helen Sarah Niblock, Daniel Hardy, Jane Elizabeth Scanlon, Rita Adrego, Nigel Ramsden