Abstract: In a management system of a communications network comprising a plurality of network elements, capacity and capability of one or more individual network elements is represented by a set of data templates. A first set of data templates represent internal construction and physical resources of a network element. A second set of templates represent connectivity capabilities of the physical resources. The data templates are stored at an element controller, controlling a plurality of network elements. The element controller learns about the capacity and capabilities of the network elements, by receiving a set of reference messages generated by the network elements, over an operations, administration and maintenance channel. The reference messages point to the data templates stored at the element controller thereby enabling efficient enrollment of network elements by transmission of compressed messages over the operations, administration and maintenance channel.

Abstract: Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

Abstract: A trail explorer and method for exploring trails in a communication network is described. The trail explorer is provided in a trail managing system having a trail database for storing connections in the network. The trail explorer compares the connections stored in the database and those actually provisioned in the network. When a connection exists in the network but is missing from the database, the trail explore triggers a learn process. If a connection exists in the database but is missing from the network, it marks the connection and trails using the connection as “unprovisioned” if they are not already marked so, or delete trails if they are network learned trails.

Abstract: A trail management system for a transport network comprises a database storing data describing each of a plurality of actual and intended/planned trails within a network. Each trail is described in terms of a state model, in which the trail is recorded as being in one of a plurality of stable states, e.g. ready for service, not ready for service, existing in the network but not fully recorded in the network management system, or assigned for deletion from the network. The trail data is modified by a set of automatic processes, by means of which a trail data may transition between stable states. Each trail data may adopt one of a plurality of sub-states, e.g. fully provisioned, incomplete, in conflict with another trail, inconsistent with another trail, unprovisioned, or unsupported by network resources. The network management system learns of actual existing trails within the network and checks for consistency of actual trails with stored trail data.

Abstract: Score values representing a user's subjective rating of a condition as recorded using a monitor worn by or secured to the user. The monitor includes a clock for generating a periodic timing signal, a user interface for entering score values and a transducer for prompting the user to enter a score value. A time storage device stores timing information and a data storage device for stores time values and related score values. A controller activates the transducer at times indicated by the timing information. The stored time values and related score values can be read from the data storage device.

Abstract: A shank adapter for a rock drill, which is used to connect one end of a drill string to a rock drill, has a chuck end (10) made from one piece of material and an opposite, threaded end (16) made from another, different, material. The chuck end and the threaded end are permanently joined to one another in one stage of manufacturing.

Abstract: Compounds of formula I which act as amylin agonists with respect to certain desired amylin activities and as calcitonin agonists with respect to certain desired calcitonin activities are provided. Such compounds are useful in treating disturbances in fuel metabolism in mammals, including, but not limited to diabetes mellitus, including Type I diabetes and Type II diabetes. The present invention also relates to methods of treating Type I diabetes, treating Type II diabetes and to methods of beneficially regulating gastrointestinal motility comprising administration of a therapeutically effective among of one of the compounds. Also provided are pharmaceutical composition comprising a compound of formula I and a pharmaceutically acceptable carrier.

Abstract: Chimeric virus-like particles produced by a non-natural particle-forming protein. The non-natural particle forming protein comprises a self-assembling particle-forming first amino acid sequence substantially homologous with a yeast retrotransposon Ty p1 protein and a second amino acid sequence. The second sequence is antigenic and is incorporated within an epitope of the first amino acid sequence, which epitope, on particles formed from the first amino-acid sequence alone, is surface exposed. Particles formed from such proteins are immunogenic and can be used in immunotherapeutic or prophylactic vaccines or as diagnostic agents.

Abstract: Methods of use for compounds of formula (I) are described wherein R represent a --CONHOH, carboxyl (--CO.sub.2 H) or esterified carboxyl group; R.sup.1 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, aryl, aralkyl, heteroaralkyl or heteroarylthioalkyl group; R.sup.2 represents an optionally substituted phenylethyl, phenylpropyl or phenylbutyl group; R.sup.3 represents a hydrogen atom or an alkyl group; R.sup.4 represents a hydrogen atom or an alkyl group; R.sup.5 represents an optionally substituted alkyl or alkenyl group optionally interrupted by one or more --O-- or --S-- atoms or --N(R.sup.7)-- groups (where R.sup.7 is a hydrogen atom or a C.sub.1-6 alkyl group); X represents an amino (--NH.sub.2), or substituted amino, hydroxyl or substituted hydroxyl group; and the salts, solvates and hydrates thereof.

Abstract: Compounds of formula (1) are described, wherein R.sup.1 represents (a), where R.sup.3 is a hydrogen or halogen atom or a methyl, trifluoromethyl or methoxy group; R.sup.2 represents a hydrogen atom or a methyl group; and the salts, solvates, hydrates and prodrugs thereof. The compounds are potent and selective orally active inhibitors of the metalloproteinase gelatinase with a long duration of action, and in particular inhibit angiogenesis in vivo. They can therefore be expected to be of use in the prophylaxis or treatment of angiogenesis dependent disorders such as solid tumours and arthritic diseases.

Abstract: Compositions and methods for reducing food intake, suppressing appetite and controlling body weight are provided. Such compositions may include an amylin agonist and a CCK agonist or a hybrid peptide.