Abstract: An energy management system may include a tokenization platform coupled with at least one energy accounting system. The energy management system may include at least one transaction monitor that may be configured to fetch transaction trace data, from the at least one energy accounting system, for executing at least one energy-related transaction between at least one first entity and at least one second entity. The at least one transaction monitor may further be configured to perform transaction reconciliation for the at least one first entity and the at least one second entity based on the fetched transaction trace data. The energy management system may include at least one token manager that may be configured to orchestrate one or more energy-backed tokens based on the transaction reconciliation for the first entity and the second entity.

Abstract: Predictive energy management comprising systems and methods to collect information about the configuration of energy resources and historical data about energy utilization as to make recommendations on how to optimize those energy resources are disclosed. Intelligent distributed energy resources (IDERs) which are devices that are energy producers or consumers that are automatable with application programming interfaces are aggregated together. An intelligent energy profile, which comprises a summary of energy resources and historical data about utilization is generated. A predictive algorithm is applied to the intelligent energy profile thereby generating a predicted future state, and a recommendation on how to optimize against that predicted future state is generated. In some embodiments generative artificial intelligence techniques are utilized, and in some embodiments the recommendations are automatically performed via the generation of computer script embodying the recommendations.

Abstract: An energy accounting system for integration of one or more data centers may include a virtualization platform configured to interface with a plurality of server components. The plurality of the server components may be itemized into Integrated Distributed Energy Resources (IDERs). The energy accounting system may further include an Energy Orchestration Module (EOM) communicatively coupled with the virtualization platform. The EOM may be configured to aggregate the IDERs into a Virtual Power Plant (VPP) and may fetch telemetry data associated with the individual ones of the plurality of the server components. The EOM may further be configured to analyze the fetched telemetry data and the fetched workload data and may further generate data analysis products for benefit of energy optimization of the VPP.

Abstract: Predictive energy management across a plurality of microgrids situated at disparate facilities is disclosed. Each microgrid may include one or more distributed energy resources (DERs). Reception of profile data from these microgrids and the creation of aggregated profiles is enabled, which may incorporate the profile data, charts of accounts, energy transfer tariffs, and other energy-related attributes. An event detection engine may identify triggering events such as energy surpluses, deficits, or operational conditions, indicating a benefit to energy reallocation. A recommendation engine may generate energy allocation recommendations based on predictive models, optimizing factors like cost efficiency, carbon offset utilization, and energy availability. The recommendations may be executed through an aggregation server, which dynamically updates the aggregated profiles in real-time.

Abstract: Global Energy Management comprising systems and methods to collect information about the configuration of energy resources and historicals about energy utilization as to make recommendations on how to optimize those energy resources are disclosed. Global Energy Management provides of adaptation regardless of location and whether or not data fields from the collecting information and historicals agree. Specifically, Global Energy Management makes use of ontology techniques to find corresponding data fields and makes use of software based estimation techniques such as interpolation, extrapolation, and statistical analysis to fill in missing data. Global Energy Management then creates energy profiles comprising data sets for different collections of energy resources, makes predictions and recommendations for the aggregated energy resources from the different collections, and in some cases automates the recommendations.

Abstract: The present invention related to a method and a predictive energy platform for generating a predictive digital twin for at least one power grid. The method may include receiving one or more energy resource operational attributes, from at least one profile manager, corresponding to a plurality of integrated distributed energy resources (IDERs). The method may further include generating, using at least one digital twin model, at least one digital twin of the at least one power grid by creating at least one energy network graph based on the received one or more energy resource operational attributes corresponding to the plurality of IDERs. The method may further include integrating external data with the at least one generated energy network graph for benefit of generating at least one analysis product.

Abstract: An energy management platform may include at least one energy profile manager configured to receive one or more energy records of one or more energies from one or more energy sources. The energy management platform may further include at least one energy analysis engine configured to analyze one or more energy-related attributes corresponding to the one or more received energy records by the at least one energy profile manager. The management platform may further include an allocation manager configured to detect at least one business rule associated with one or more energy allocation requirements of at least one entity. The allocation manager may further be configured to allocate the one or more energies corresponding to the one or more received energy records in accordance with the at least one detected business rule.

Abstract: Systems for microgrid interfacing may include a virtual resource platform (VRP) for integration and management of a plurality of integrated distributed energy resources (IDERs). The VRP may include at least one request-handling interface to process requests for interfacing IDERs, a driver identification engine to retrieve resource metadata attributes and identify compatible drivers, and a standardized application programming interface (API) for cross-platform compatibility. The VRP may further include a predictive energy manager. The predictive energy manager may fetch telemetry data from the IDERs, analyze the data using machine-learning-based models, and may generate energy management analysis products.

Abstract: The present invention relates to managing and certifying energy transactions in an energy accounting system. The present invention provides a framework for receiving energies, organizing, and accounting energy-related transactions of the received energies through a general ledger and a chart of accounts. The present invention further enables tracking of the received energies through cryptographic certificates that are further convertible into exchangeable cryptographic artifacts for trading the energies. The present invention provides an ontology engine that normalizes energy-associated terminology to enable compliance with standardized terminology. A reporting manager generates detailed reports, for example, reports for Sustainable Development Goals (SDG) compliance, carbon net-zero assessments, and other sustainability metrics.

Abstract: Described herein are treatments and preventions for cancer using antibodies that bind to TIGIT, and uses of an anti-TIGIT antibody in the manufacture of a medicament for the treatment or prevention of cancer. Also described herein are methods of blocking binding of TIGIT to CD155 without altering certain immune parameters by administering an antibody that binds to TIGIT.

Abstract: The present disclosure describes techniques to detect and remediate cybersecurity threats within an enterprise network. More specifically, a Data Management Operating System (DMOS) analysis server is described that is configured to detect and remediate interactions initiated by enterprise devices with data items stored within an enterprise network. The DMOS analysis server may be configured to capture, via a security client that resides on the enterprise device, datum metadata associated with a data operation initiated by the enterprise device, analyze the datum metadata to determine whether the data operation is associated with a cybersecurity threat, and in doing so facilitate an execution of the data operation. In some examples, the DMOS analysis server may generate a response protocol for delivery to a global key server to facilitate execution of the data operation or restrict access to the data item by the enterprise device.

Abstract: A method and system of transporting data securely. A payload comprising a first encrypted data is serialized. The serialized payload is prepended with a first header to create a first data packet. The first data packet is encrypted using the second key to create a second data packet. The second data packet is prepended with a second header to create a third data packet. The third data packet is transported to a destination via a secure data transport.

Abstract: A method and system of securing data. A security client program stored in a memory of a user device intercepts an operating system call performed by a calling application of the user device for an unencrypted asset. A first key for the unencrypted asset from a server is requested. Upon receiving the first key for the unencrypted asset from a server, a secure resource is created by encrypting the unencrypted asset. Then, the operating system call is completed and an update message is sent to the server.

Abstract: A method and system of securing data. A security client program stored in a memory of a user device intercepts an operating system call performed by a calling application of the user device for an unencrypted asset. A first key for the unencrypted asset from a server is requested. Upon receiving the first key for the unencrypted asset from a server, a secure resource is created by encrypting the unencrypted asset. Then, the operating system call is completed and an update message is sent to the server.

Abstract: A method and system of transporting data securely. A payload comprising a first encrypted data is serialized. The serialized payload is prepended with a first header to create a first data packet. The first data packet is encrypted using the second key to create a second data packet. The second data packet is prepended with a second header to create a third data packet. The third data packet is transported to a destination via a secure data transport.

Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

Abstract: The present invention relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Cdc25. The invention also relates to the use of the three dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.

Abstract: The present invention relates to compounds that are inhibitors of interleukin-1&bgr; converting enzyme that have the Formula (I). This invention also relates to a method of treatment of stroke, reperfusion injury, Alzheimer's disease, shigellosis, inflammatory diseases, and septic shock and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1&bgr; converting enzyme.

Abstract: The present invention relates to compounds that are inhibitors of interleukin-1&bgr; converting enzyme that have the Formula (I). This invention also relates to a method of treatment of stroke, reperfusion injury, Alzheimer's disease, shigellosis, inflammatory diseases, and septic shock and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1&bgr; converting enzyme.