Patents by Inventor Nigel Walker

Nigel Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfonamide interleukin-1&bgr; converting enzyme inhibitors
    Patent number: 6316415
    Abstract: The present invention relates to compounds that are inhibitors of interleukin-1&bgr; converting enzyme that have the Formula (I). This invention also relates to a method of treatment of stroke, reperfusion injury, Alzheimer's disease, shigellosis, inflammatory diseases, and septic shock and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1&bgr; converting enzyme.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: November 13, 2001
    Assignees: BASF Aktiengesellschaft, Warner-Lambert Company
    Inventors: Hans P. Albrecht, Hamish John Allen, Kenneth Dale Brady, William Glen Harter, Catherine Rose Kostlan, Bruce David Roth, Nigel Walker
  • Sulfonamide substituted aspartic acid interleukin-1.beta. converting enzyme inhibitors
    Patent number: 6083981
    Abstract: The present invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme that have the Formula I, II, or III. ##STR1## This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: July 4, 2000
    Assignee: Warner-Lambert Company
    Inventors: Hamish John Allen, Kenneth Dale Brady, William Glen Harter, Elizabeth Ann Lunney, Mark Stephen Plummer, Tomi Sawyer, Aurash Shahripour, Nigel Walker
  • Hydroxamate inhibitors of interleukin-1.beta. converting enzyme
    Patent number: 5919790
    Abstract: The present invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme that have the Formula II ##STR1## This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock, reperfusion injury, Alzheimer's disease, shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: July 6, 1999
    Assignees: Warner-Lambert Company, BASF Aktiengesellsschaft
    Inventors: Hamish John Allen, Kenneth Dale Brady, Bradley William Caprathe, Paul Galatsis, John Lodge Gilmore, Sheryl Jeanne Hays, Robert Vincent Talanian, Nigel Walker, Joseph Scott Warmus
  • Organic-chemical compound with ice-inhibitory action
    Patent number: 5798247
    Abstract: Organic chemical compounds with ICE-inhibitory action which have structures such that they enter into an interaction with binding sites in a binding cavity.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: August 25, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Peter Albrecht, Hans-Joachim Bohm, Kenneth Dale Brady, Peter Eckard, Kurt Ritter, Robert Vincent Talanian, Nigel Walker
  • Substituted pyrido[2, 3-dipyrimidines as antidotes for herbicidal cyclohexenones
    Patent number: 5597776
    Abstract: Herbicides containing at least one substituted pyrido[2,3-d]pyrimidine I ##STR1## or a plant-tolerated salt of those compounds I in which at least one of the substituents R.sup.1 to R.sup.5 is an acidic or a basic group,and at least one herbicidal active ingredient selected fromA) the group consisting of the cyclohexenone derivatives II, orB) the group consisting of the 2-(heteroaryloxy)- or 2-(4-aryloxy)-phenoxycarboxylic acid derivative.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: January 28, 1997
    Assignee: BASF Aktiengesellschaft
    Inventors: Matthias Bratz, Reiner Kober, Rainer Seele, Thomas Saupe, Norbert Meyer, Nigel Walker, Andreas Landes, Helmut Walter
  • Ice-mediated introduction of substances into biological material
    Patent number: 5219746
    Abstract: Methods and apparatus for the introduction of foreign substances, such as recombinant DNA, into living cell interiors is disclosed. The desired substance to be introduced is dissolved or suspended in water or another suitable liquid to form a solution which is then nebulized and frozen to produce ice particles. These ice particles are accelerated toward and impact upon a target tissue where some of the particles impregnate at least some cells in the target tissue without killing the cells. Following impregnation, the ice particles melt, leaving behind the desired substance in the protoplasm of the bombarded cell.
    Type: Grant
    Filed: March 31, 1992
    Date of Patent: June 15, 1993
    Inventors: Chris Brinegar, James Gilmore, Michael Johnson, Nigel Walker