Abstract: Methods for determining the relative abundance of viral capsid components in a sample of viral particles are disclosed. In embodiments, methods for determining the relative abundance of empty capsids, partially-full capsids and full capsids (e.g., containing a heterologous nucleic acid molecule) of adeno-associated virus are disclosed.

Abstract: A query processing method, an electronic device and a storage medium based on a large model, relating to artificial intelligence fields such as deep learning, large models, intelligent cloud, natural language processing and retrieval-augmented generation, are provided. The method may include: acquiring a target query to be processed; retrieving based on the target query from M predetermined data sources to obtain a first retrieval result, and inputting the target query and the first retrieval result into a target large model, where M is a positive integer; acquiring and displaying a target answer output by the target large model in a streaming output manner, where the target answer is an answer corresponding to the target query, and during a streaming output process, performing keyword recognition on output text content, and generating and displaying a knowledge card corresponding to a keyword.

Abstract: The present invention provides a preparation method of a supported metal catalyst with synergistic sites. The method is to utilize the unsaturated cubane-like structure, M cation with catalytic activity is introduced into the cluster core unit. By using the vertex vacancy as the capturing center, and adjusting the impregnation temperature to maximize the loading of the cluster precursor, Depending on the electrostatic adsorption of the support and the confinement of the cluster structural unit, the number of S vacancies and the distance between S vacancies and Miso sites are effectively controlled through liquid phase reduction and atmosphere treatment at room temperature to obtain supported X3MSx/Al2O3 catalyst with Miso-Vs synergistic sites.

Abstract: A test device and a method for testing a photovoltaic module, for testing anti-stepping performance of the photovoltaic module. A test member is configured to abut against the photovoltaic module and apply a preset load to the photovoltaic module, to simulate force on the photovoltaic module when an operator walks on a surface of the photovoltaic module, so as to easily adjust and replace the material and the manufacturing process of the photovoltaic module according to test results, so that the photovoltaic module has stronger anti-stepping performance, thereby prolonging the service life of the photovoltaic module. The test member is provided with an abutment surface for abutting against the photovoltaic module, and an area S of the abutment surface satisfies: 50 cm2?S?400 cm2, which improves accuracy and reliability of the test results of the test device, thereby improving operation performance of the test device.

Abstract: Disclosed are an X-ray generation device and an X-ray imaging system. The device comprises a suspension assembly, a head assembly, an electric assist assembly, a combined multi-dimensional force sensor, and a controller. The suspension assembly includes a guide rail, a moving member, a lifting arm, and a rotating arm. The head assembly includes a connection base, a bracket, a control head, and a handle. The handle drives the control head with six degrees of freedom including translation along X, Y, Z axes and rotation about the Z-axis, a first direction, and a second direction, enabling the control head to be positioned arbitrarily within its range for imaging patients in various postures and positions. Six electric assist members drive the control head through the six degrees of freedom, allowing medical staff to operate the control head by applying minimal force to the handle, thereby saving time and effort.

Abstract: A near memory processing device, a processor and a data processing method are provided. The near memory processing device includes a memory, and a calculation core. The calculation core includes a block trace core that determines an address of a first target data block from the memory based on receiving an indirect block parse request from a processor, and calculates a checksum of a second target data block and write the calculated checksum to the memory based on receiving a checksum update request from the processor, a deduplication table search core that performs deduplication table search processing based on receiving a deduplication table query request from the processor to determine whether a third target data block exists in the memory, and a tree traverse core that traverses a range tree in the memory based on receiving a range tree query request from the processor to determine a target node corresponding to the range tree query request.

Abstract: An auxiliary device and method for recovering forepoling grouted steel pipe piles used in foundation pit support, comprising clamps, clamping hydraulic shafts, an upper plane, lifting hydraulic shafts, and a main plane. The clamping hydraulic shafts are mounted on the upper plane, with four shafts installed. The lifting hydraulic shafts are fixed to the main plane, with their output ends connected to the upper plane. Both the upper plane and main plane are designed to sleeve onto the forepoling grouted steel pipe piles. The recovery device and method disclosed in this invention can significantly improve the recycling rate of forepoling grouted steel pipe piles, thereby substantially reducing construction costs. This innovation not only enhances economic efficiency but also actively promotes low-carbon emission reduction during construction, making positive contributions to environmental protection and sustainable development.

Abstract: Provided is a cross-machine few-shot fault diagnosis method based on a retrospective prototypical network (RPN), which belongs to the technical field of fault diagnosis. First of all, through a multi-scale hybrid dilated convolutional feature extraction module, highly abstract sample features are extracted from a vibration signal acquired in a complex scenario. Then, a retrospective prototype representation and update method is proposed to optimize a class prototype with internal structures of data, more accurately reflecting a complex distribution of a class, and effectively reducing prototype oscillation and feature distribution differences between batches. In addition, a new similarity evaluation method, namely a central difference metric (CDM), is proposed to calculate a difference between the internal structures of the data, providing a more flexible similarity evaluation tool for a few-shot diagnosis task.

Abstract: Systems and methods comprising a metering device located on an electricity distribution grid, the metering device comprising one or more processors and memory. The metering device can detect a drop in characteristic of electricity below a threshold indicating a fault on the electricity distribution grid. The metering device can generate, responsive to the drop in the characteristic of electricity below the threshold, a time series of a rate of change of the characteristic of electricity for a predetermined number of cycles subsequent to the detection of the drop. The metering device can determine, based on a comparison of the time series of the rate of change with a predetermined pattern, a location of the metering device on the electricity distribution grid relative to a location of the fault on the electricity distribution grid.

Abstract: Disclosed is a class of kinase inhibitors. Related pharmaceutical compositions and methods of making and using the kinase inhibitors are also disclosed.

Abstract: The present invention generally pertains to methods of preventing disulfide scrambling in non-reducing liquid chromatography-mass spectrometry analysis of a protein of interest. In particular, the present invention pertains to the addition of maleimide to a non-reducing liquid chromatography-mass spectrometry analysis of a protein to prevent disulfide scrambling.

Abstract: A composition and use thereof. The composition comprises an active component a and an active component b; the active component a is a compound as shown in general formula A; and the active component b is at least one of compounds which have insecticidal, acaricidal or bactericidal activity and are different from the compound as shown in general formula A. The composition has the advantages of synergistic effect and expanding prevention and treatment spectrum, and can be used for preventing and treating various pests, particularly mite damage, and plant diseases caused by various fungi, bacteria, nematodes and viruses.

Abstract: An ultrahigh-pressure acid-fracturing isodiametric hose assembly, comprising a hose body and a metal joint. The metal joint comprises an inner tube, a first outer tube the inner tube, and a second outer tube. The first outer tube and the second outer tube each is an independent pressing part. An external groove is provided at an outer wall of the inner tube. An end of the first outer tube comprises an internal ridge which matches the external groove for snapping. The terminal of the inner tube comprises a connecting portion. An outer wall of the inner tube comprises a first protrusion, and an inner wall of the first outer tube comprises a second protrusion engaging with the first protrusion. The hose body is clamped between the first protrusion and the second protrusion that are engaged. An inner wall of the second outer tube comprises multiple micro-protrusions.

Abstract: The embodiments of the present disclosure disclose a plastic bottle compression and recycling device. The plastic bottle compression and recycling device includes a housing, and a compression cavity, a binding part, a compression part, a feeding part, a conveying part, a discharging part and a controller that are located inside the housing.

Abstract: A drug containing, as an active ingredient, a compound having an antagonistic activity against an EP2 receptor in the prevention and/or treatment of a disease associated with the activation of an EP2 receptor, of formula (I-A): wherein all symbols have the same meanings as those described in the specification, or a pharmaceutically acceptable salt thereof.

Abstract: A latency-oriented Service Level Optimization system for multi-tenant databases. Latency's negative effect on Quality of Service is expressed in terms of a latency impact function to provide a latency impact-oriented SLO-guaranteed system that enables a database system to support multi-tenant latency-impact targets in a cost-effective fashion. In contrast to traditional latency management based on percentile guarantees, the present invention manages latency based on the latency probability density function for all latency values. Cost-effective management is attained through latency impact-oriented capacity planning and real-time latency impact target enforcement. The capacity planning estimates the feasibility of latency-impact targets while the target enforcement tracks and regulates the per-connection query latency distribution needed for accurate latency-impact target guarantee, avoiding both under-provisioning and over-provisioning.

Abstract: A test device and a method for testing a photovoltaic module, for testing anti-stepping performance of the photovoltaic module. The test device includes first and second test members spaced apart along a first direction. The first and second test members are configured to abut against the photovoltaic module and apply a preset load to the photovoltaic module. The first test member is at a first position when the first test member abuts against the photovoltaic module, the second test member is at a second position when the second test member abuts against the photovoltaic module, and along a movement direction of the first and second test members in a horizontal plane, the first and second positions are alternately spaced apart, to simulate force on the photovoltaic module when an operator walks on the photovoltaic module.

Abstract: The present invention generally pertains to methods of detecting host cell proteins. In particular, the present invention pertains to the use of a novel activity-based protein profiling probe to identify host cell proteins with lipase activity in a pharmaceutical formulation.

Abstract: A semiconductor layout structure includes: active layers, each active layer including a first active area and a second active area arranged adjacent to the first active area, the first active area including first transistor areas spaced apart from each other, the second active area including second transistor areas spaced apart from each other; and gate layers, each gate layer being arranged above a respective active layer, and including at least one first gate structure extending along a first direction, and second gate structures spaced apart from each other in the first direction, and the at least one first gate structure and the second gate structures being arranged adjacent to each other, the at least one first gate structure corresponding to the first transistor areas, and each second gate structure corresponding to a second transistor area.

Abstract: The present disclosure provides a perfusion system and a cell cultivation perfusion system, the perfusion system comprising: a pressure transfer component, the pressure transfer component including a belt and multiple pressure members disposed on the belt at intervals; a driving device, a driving connection being established between the driving device and the pressure transfer component; and at least one pipeline assembly, the at least one pipeline assembly including at least one pressable pipeline for fluid flow; wherein a press area is formed between the pressure transfer component and each of the at least one pressable pipeline, the multiple pressure members move with the belt, and at least a portion of the multiple pressure members press against the at least one pressable pipeline in the press area.