Abstract: A microfluidic viscometer measures the viscosity of a microliter-volume fluid sample using a microfluidic chip having a microchannel with a high aspect ratio (˜10), allowing the microflow therein to be approximated as a rectangular slit flow. The microfluidic chip is fabricated by stacking rigid sheet materials that can be laser cut to specified shapes and sizes. The microchannel, rendered smooth and hydrophobic by a repellant coating, provides a straight flow path for the sample to approach flow equilibrium as it moves through. By applying corrections related to the visual bias from the camera and the capillary pressure difference at the air-liquid interface, the viscosity of the fluid sample can be calculated based on differential pressure data, sample length, velocity, volumetric flow rate, and contact angle from captured video, and the channel dimension, given that the sample has reached a flow equilibrium condition.

Abstract: A flexible flat coaxial ribbon cable, equipped with a plurality of coaxial cables arranged side by side to reduce the degree of interference and loss during transmitting RF signals or high-speed signals through the coaxial cables, thereby effectively increasing the transmission distance for RF signals or high-speed signals. Additionally, the coaxial cables used in the flexible flat coaxial ribbon cable of this application omits an outer insulation layer, allowing the thickness of the flexible flat coaxial ribbon cable to be effectively reduced for use in spaces with height constraints.

Abstract: A microfluidic viscometer measures the viscosity of a microliter-volume fluid sample using a microfluidic chip having a microchannel with a high aspect ratio (˜10), allowing the microflow therein to be approximated as a rectangular slit flow. The microfluidic chip is fabricated by stacking rigid sheet materials that can be laser cut to specified shapes and sizes. The microchannel, rendered smooth and hydrophobic by a repellant coating, provides a straight flow path for the sample to approach flow equilibrium as it moves through. By applying corrections related to the visual bias from the camera and the capillary pressure difference at the air-liquid interface, the viscosity of the fluid sample can be calculated based on differential pressure data, sample length, velocity, volumetric flow rate, and contact angle from captured video, and the channel dimension, given that the sample has reached a flow equilibrium condition.

Abstract: A self-retracting lifeline assembly (10) includes a housing (12), a shaft (14) fixed to the housing (12) against rotation, a drum (18) mounted for rotation on the shaft (14) and including a compartment (20) within the drum (18), a lifeline (22) wound on the drum (18), a brake module (24) carried on the shaft (14) and mounted within the compartment (20), and a pawl mechanism (26) mounted on the drum (18) for rotation therewith. The pawl mechanism (26) is mounted within the compartment (20) and configured to selectively engage the brake module (24).

Abstract: The present application provides use of Compound (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof in manufacture of a medicament useful in treating a disease related to high expression or abnormal activation of JAK and SYK kinases, comprising an autoimmune disease, such as an immune-mediated skin disease, in particular psoriasis, atopic dermatitis and SLE. Compound (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention can improve the skin lesions in mice with psoriasis, atopic dermatitis and SLE, alleviate the injury of kidney, inhibit the expansion of immune organs, reduce the level of inflammation, inhibit the increase of SLE related antibodies and cytokines in serum, and has a certain safe therapeutic window, which has a good clinical application prospect.

Abstract: A self-retracting lifeline assembly (10) includes a housing (12), a shaft (14) fixed to the housing (12) against rotation, a drum (18) mounted for rotation on the shaft (14) and including a compartment (20) within the drum (18), a lifeline (22) wound on the drum (18), a brake module (24) carried on the shaft (14) and mounted within the compartment (20), and a pawl mechanism (26) mounted on the drum (18) for rotation therewith. The pawl mechanism (26) is mounted within the compartment (20) and configured to selectively engage the brake module (24).

Abstract: Apparatus and associated methods relate to a body-worn unitary harness having a shoulder portion and a waist portion in tensile communication with one another, such that both the shoulder and the waist portions can be simultaneously adjusted using a single adjustment mechanism to conform to a wearer's body. In an illustrative embodiment, a length of webbing may thread through an angle-turning buckle and change direction therein. Tensile forces in the length of webbing may be directed in different directions on either side of the angle-turning buckle. A single clasp may facilitate both donning and doffing of the unitary harness. An implement connector may be coupled to a hip member and configured to connect an implement to the unitary harness. Various exemplary unitary harnesses may provide comfortable implement carrying capacity while automatically adjusting relative waist and shoulder lengths to accommodate a user's movements and positions.

Abstract: A self-retracting lifeline assembly (10) includes a housing (12), a shaft (14) fixed to the housing (12) against rotation, a drum (18) mounted for rotation on the shaft (14) and including a compartment (20) within the drum (18), a lifeline (22) wound on the drum (18), a brake module (24) carried on the shaft (14) and mounted within the compartment (20), and a pawl mechanism (26) mounted on the drum (18) for rotation therewith. The pawl mechanism (26) is mounted within the compartment (20) and configured to selectively engage the brake module (24).

Abstract: A nacelle defining an intake is provided for channelling and conditioning freestream airflow to a fan of a ducted fan gas turbine engine. The nacelle intake comprises in flow series an intake lip, and a diffuser. The intake lip has at its forwardmost end a highlight which is a closed loop defining a boundary between inner and outer surfaces of the nacelle, and the diffuser terminates at its rearwardmost end at a front face of the fan. The intake has a circumferentially extending shock control bump or a series of circumferentially spaced shock control bumps formed thereon.

Abstract: A self-retracting lifeline assembly (10) includes a housing (12), a shaft (14) fixed to the housing (12) against rotation, a drum (18) mounted for rotation on the shaft (14) and including a compartment (20) within the drum (18), a lifeline (22) wound on the drum (18), a brake module (24) carried on the shaft (14) and mounted within the compartment (20), and a pawl mechanism (26) mounted on the drum (18) for rotation therewith. The pawl mechanism (26) is mounted within the compartment (20) and configured to selectively engage the brake module (24).

Abstract: Apparatus and associated methods relate to a body-worn unitary harness having a shoulder portion and a waist portion in tensile communication with one another, such that both the shoulder and the waist portions can be simultaneously adjusted using a single adjustment mechanism to conform to a wearer's body. In an illustrative embodiment, a length of webbing may thread through an angle-turning buckle and change direction therein. Tensile forces in the length of webbing may be directed in different directions on either side of the angle-turning buckle. A single clasp may facilitate both donning and doffing of the unitary harness. An implement connector may be coupled to a hip member and configured to connect an implement to the unitary harness. Various exemplary unitary harnesses may provide comfortable implement carrying capacity while automatically adjusting relative waist and shoulder lengths to accommodate a user's movements and positions.

Abstract: Apparatus and associated methods relate to a body-worn unitary harness having a shoulder portion and a waist portion in tensile communication with one another, such that both the shoulder and the waist portions can be simultaneously adjusted using a single adjustment mechanism to conform to a wearer's body. In an illustrative embodiment, a length of webbing may thread through an angle-turning buckle and change direction therein. Tensile forces in the length of webbing may be directed in different directions on either side of the angle-turning buckle. A single clasp may facilitate both donning and doffing of the unitary harness. An implement connector may be coupled to a hip member and configured to connect an implement to the unitary harness. Various exemplary unitary harnesses may provide comfortable implement carrying capacity while automatically adjusting relative waist and shoulder lengths to accommodate a user's movements and positions.

Abstract: The present invention provides (1) a set of novel DNA primers that can be used for high efficient real-time qPCR of Hepatitis B virus (HBV) circular DNA (cccDNA) and (2) a novel high throughput method for quantification of HBV cccDNA from cells using this set of novel DNA Primers by real-time qPCR. It also provides a use of this method in monitoring cccDNA level in experimentally infected liver cells and evaluation of therapeutic effect on HBV.

Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.

Abstract: A self-retracting lifeline assembly (10) includes a housing (12), a shaft (14) fixed to the housing (12) against rotation, a drum (18) mounted for rotation on the shaft (14) and including a compartment (20) within the drum (18), a lifeline (22) wound on the drum (18), a brake module (24) carried on the shaft (14) and mounted within the compartment (20), and a pawl mechanism (26) mounted on the drum (18) for rotation therewith. The pawl mechanism (26) is mounted within the compartment (20) and configured to selectively engage the brake module (24).

Abstract: A method of connecting three-dimensional structured meshes to form a conformal mesh, for solutions of flow problems, including: forming an interface by overlaying surfaces of two structured meshes; defining an interface set of mesh points in the interface; merging mesh points in the interface set that are within a predetermined distance of each other and projecting mesh points of one mesh in the interface that are within a predetermined distance of a line of the other mesh; generating an interface layer in the form of an unstructured mesh; and inserting a node at the center of each hexahedra, and producing an unstructured layer of cells between the two structured meshes by joining the nodes to the mesh points of the interface layer.

Abstract: The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

Abstract: A casing treatment for a fan or compressor stage 10 of a gas turbine engine comprises circumferential grooves 16A, 16B, 16C, 16D and 16E which extend in a series disposed between the leading edges 20 and trailing edges 22 of blades 6 of a fan or compressor stage 10. The grooves 16 vary in depth d in order to optimise the stall margin of the fan or compressor stage 10 while preserving peak efficiency.

Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.