Patents by Inventor Ning Qin

Ning Qin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COLD MENTHOL RECEPTOR-1 ANTAGONISTS
    Publication number: 20080027029
    Abstract: The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
    Type: Application
    Filed: May 9, 2007
    Publication date: January 31, 2008
    Inventors: Raymond Colburn, Scott Dax, Christopher Flores, Jay Matthews, Ning Qin, Laura Reany, Christopher Teleha, Mark Youngman
  • Human cyclooxygenase-3 enzyme and uses thereof
    Publication number: 20070166789
    Abstract: The present invention provides nucleic acid and polypeptide sequences describing a novel isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase-3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
    Type: Application
    Filed: January 10, 2007
    Publication date: July 19, 2007
    Inventors: Ning Qin, Ellen Codd, Christopher Flores, Sui-Po Zhang
  • Compositions and methods for identifying modulators of TRPV2
    Publication number: 20070105086
    Abstract: It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.
    Type: Application
    Filed: October 30, 2006
    Publication date: May 10, 2007
    Inventors: Ning Qin, Yi Liu, Christopher Flores, Tasha Hutchinson, Michael Neeper
  • Polypeptide complex of TRPM8 and calmodulin and its uses thereof
    Publication number: 20070105155
    Abstract: The present invention discovered that a mammalian TRPM8 binds to calmodulin. The present invention provides a polypeptide complex comprising a cold-menthol receptor (TRPM8) or an active fragment or derivative of TRPM8 and a calmodulin or an active fragment or derivative of calmodulin, and the uses of the polypeptide complex.
    Type: Application
    Filed: October 31, 2006
    Publication date: May 10, 2007
    Inventors: Ning Qin, Christopher Flores
  • CDNA encoding the human ?2 ?4 calcium channel subunit
    Patent number: 7157248
    Abstract: The present invention provides nucleic acid and polypeptide sequences describing a novel isoform of the ?2? subunit of a voltage gated calcium channel, herein named as ?2?-4. The isolated nucleic acid or polypeptide molecule of the invention can be used in diagnosing and treating a disease or disorder associated with a defective ?2?-4 subunit, such as seizure-related syndromes, anxiety, multiple sclerosis, and the like.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: January 2, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ning Qin, Ellen Codd
  • Human voltage gated sodium channel beta1A subunit and methods of use
    Publication number: 20060269996
    Abstract: DNAs encoding human voltage gated sodium channel ?1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
    Type: Application
    Filed: March 8, 2006
    Publication date: November 30, 2006
    Inventors: Ning Qin, Ellen Codd, Michael D'andrea
  • Human voltage gated sodium channel ?1A subunit and methods of use
    Patent number: 7063953
    Abstract: DNAs encoding human voltage gated sodium channel ?1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: June 20, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ning Qin, Ellen Codd, Michael D'Andrea
  • Human voltage gated sodium channel ?1A subunit and methods of use
    Patent number: 6994993
    Abstract: DNAs encoding human voltage gated sodium channel ?1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: February 7, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ning Qin, Ellen Codd, Michael D'Andrea
  • Canine cold- and menthol-sensitive receptor 1
    Publication number: 20060014246
    Abstract: The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays and screening assays.
    Type: Application
    Filed: April 6, 2005
    Publication date: January 19, 2006
    Inventors: Christopher Flores, Yi Liu, Mary Lubin, Ning Qin
  • Human cyclooxygenase-3 enzyme and uses thereof
    Publication number: 20040235017
    Abstract: The present invention provides nucleic acid and polypeptide sequences describing a novel isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase-3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
    Type: Application
    Filed: February 20, 2004
    Publication date: November 25, 2004
    Inventors: Ning Qin, Ellen E. Codd, Christopher Flores, Sui-Po Zhang
  • Human voltage gated sodium channel beta1A subunit and methods of use
    Publication number: 20040002439
    Abstract: DNAs encoding human voltage gated sodium channel &bgr;1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
    Type: Application
    Filed: March 28, 2003
    Publication date: January 1, 2004
    Inventors: Ning Qin, Ellen Codd, Michael D'Andrea
  • CDNA encoding the human alpha2 delta4 calcium channel subunit
    Publication number: 20030170785
    Abstract: The present invention provides nucleic acid and polypeptide sequences describing a novel isoform of the &agr;2&dgr; subunit of a voltage gated calcium channel, herein named as &agr;2&dgr;-4. The isolated nucleic acid or polypeptide molecule of the invention can be used in diagnosing and treating a disease or disorder associated with a defective &agr;2&dgr;-4 subunit, such as seizure-related syndromes, anxiety, multiple sclerosis, and the like.
    Type: Application
    Filed: April 10, 2002
    Publication date: September 11, 2003
    Inventors: Ning Qin, Ellen Codd
  • CDNA encoding the human alpha2 delta4 calcium channel subunit
    Publication number: 20030166045
    Abstract: The present invention provides nucleic acid and polypeptide sequences describing an isoform of the &agr;2&dgr;-4 subunit of a voltage gated calcium channel. The nucleic acids described herein can be used to produce functional &agr;2&dgr;-4 protein. The calcium channel &agr;2&dgr;-4 protein may be isolated for the purposes of binding experiments or may be used in cells to form a functional calcium channel complex.
    Type: Application
    Filed: April 11, 2001
    Publication date: September 4, 2003
    Inventors: Ning Qin, Ellen Codd
  • Human voltage gated sodium channel beta1A subunit and methods of use
    Publication number: 20020045229
    Abstract: DNAs encoding human voltage gated sodium channel &bgr;1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
    Type: Application
    Filed: June 6, 2001
    Publication date: April 18, 2002
    Inventors: Ning Qin, Ellen Codd, Michael D'Andrea