Abstract: The present application relates to a method and system of mechanical ventilation therapy data management. The method includes: putting patient information and real-time received mechanical ventilation therapy data into a standard data structure object respectively to form standardized data; the mechanical ventilation therapy data comprises ventilator data; performing data cleaning on the standardized data to obtain a medical data set; performing data labeling on the mechanical ventilation therapy data in the medical data set; the data labeling comprises: marking amplitudes, frequencies, and shapes of waveform data, marking measurement values of numerical data, and marking abnormal events; when a report generation instruction is received, generating a mechanical ventilation therapy data analysis report based on the medical data set with the data labeling.

Abstract: A method for extracting somatic mutations from single-cell transcriptome sequencing data includes processing single-cell transcriptome raw sequencing data with a first comparison and identification method to obtain a plurality of first somatic mutation sites, processing the single-cell transcriptome raw sequencing data with a second comparison and identification method to obtain a plurality of second somatic mutation sites, integrating the plurality of first somatic mutation sites and the plurality of second somatic mutation sites to obtain a plurality of candidate somatic mutation sites, and performing mutation screening on the plurality of candidate somatic mutation sites to obtain final somatic mutation sites.

Abstract: Provided in the present application are markers for predicting Coronavirus disease 2019 (COVID-19) immune checkpoint storm, an application and a kit thereof, and a preparation method of the kit, belonging to the technical field of biomedicine. The markers of the present application comprise one or more of BTLA, GITR, HVEM, IDO, LAG-3, PD-1, PD-L1, TIM-3, CD28, CD80, 4-1BB, CD27, and CD152. Predicting the COVID-19 immune checkpoint storm by using the biomarkers provided by the present application or the kit prepared therefrom has the advantages of rapid and accurate detection at low cost, and has a broad prospect of application.

Abstract: The present invention relates to compositions and methods of inhibiting p38 kinase to reduce gene and protein expression of DUX4 and downstream genes regulated by DUX4. The present invention further relates to methods for treating patients suffering from diseases associated with increased expression of DUX4 or expression of an aberrant form of DUX4, such as Facioscapulohumeral muscular dystrophy (FSHD).

Abstract: An access point that detects a duplicate address is described. During operation, the access point may receive a request associated with an electronic device, where the request includes an address of the electronic device (such as an IP address). In response, the access point may perform a comparison of the address to stored addresses of one or more electronic devices that are associated with the access point. When the comparison indicates that the address is in use by another electronic device in the one or more electronic devices, the access point may provide a response addressed to the electronic device that indicates that the address is in use. Otherwise, the access point may check with a remainder of a network to see if the address is in use. If the address is in use, the access point may provide the response.

Abstract: The present invention relates to compositions and methods of inhibiting p38 kinase to reduce gene and protein expression of DUX4 and downstream genes regulated by DUX4. The present invention further relates to methods for treating patients suffering from diseases associated with increased expression of DUX4 or expression of an aberrant form of DUX4, such as Facioscapulohumeral muscular dystrophy (FSHD).

Abstract: The invention relates to a compound of formula (I): wherein variables are as defined in the specification. The compound is an inhibitor of an ERK kinase, e.g. ERK1 and/or ERK2 kinase. The invention also relates to the use of the compound and a method for preparing the compound, and a pharmaceutical composition containing the compound.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, orZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: The present invention relates to compositions and methods of inhibiting p38 kinase to reduce gene and protein expression of DUX4 and downstream genes regulated by DUX4. The present invention further relates to methods for treating patients suffering from diseases associated with increased expression of DUX4 or expression of an aberrant form of DUX4, such as Facioscapulohumeral muscular dystrophy (FSHD).

Abstract: The invention relates to a compound of formula (I): wherein variables are as defined in the specification. The compound is an inhibitor of an ERK kinase, e.g. ERK1 and/or ERK2 kinase. The invention also relates to the use of the compound and a method for preparing the compound, and a pharmaceutical composition containing the compound.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: An earthquake alarm device, including an alarm lamp and a base. Inside the alarm lamp, there is a power supply module and an earth magnetic field detection module. The earth magnetic field detection module emits a sound and light early warning signal when identifying any earth field abnormality. The vibration sensing module I senses slight vibration and emits a sensing signal I. The vibration sensing module II senses strong vibration and emits a sensing signal II. The control chip II emits sound and light alarm signals after receiving the sensing signal II or the sensing signal I and sound and light early warning signal at the same time. The alarm lamp gives a light alarm after receiving a sound and light early warning signal. The lighting module receives sound and light early warning signals or sound and light alarm signals and provides lighting.

Abstract: An earthquake alarm device, including an alarm lamp and a base. Inside the alarm lamp, there is a power supply module and an earth magnetic field detection module. The earth magnetic field detection module emits a sound and light early warning signal when identifying any earth field abnormality. The vibration sensing module I senses slight vibration and emits a sensing signal I. The vibration sensing module II senses strong vibration and emits a sensing signal II. The control chip i emits sound and light alarm signals after receiving the sensing signal II or the sensing signal I and sound and light early warning signal at the same time. The alarm lamp gives a light alarm after receiving a sound and light early warning signal. The lighting module receives sound and light early warning signals or sound and light alarm signals and provides lighting.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: Various methods and systems are provided for controlling and shaping the current waveform for a solenoid in a fuel injector that has variable impedance.

Abstract: A system and method are provided for producing radio-frequency (RF) coverage maps for networks of ground stations. The coverage maps are produced from ground station log files that are generated for a particular network of RF radio stations, including an ARINC VHF Data Link Mode 2 (VDLM2) Network. A coverage map regarding interactive communications between aircraft and various ground stations at a particular location therefrom is generated based on actual available operating data including geographic locating of an aircraft, which may be according to Global Positioning Satellite (GPS) system data or other aircraft geolocating data, and Received Signal Strength Indication (RSSI) measurements for the data exchange with the aircraft.