Abstract: An information handling system couples a solid state drive assembly having plural solid state drives to a motherboard with a single M.2 connector coupled to the motherboard by interfacing the plural solid state drives with an adapter circuit board having an M.2 interface defined at one end to insert into the motherboard connector and having plural M.2 connectors to interface with the plural solid state drives in a desired configuration, such as a stacked vertical configuration that more efficiently uses motherboard footprint to include persistent memory.

Abstract: Disclosed herein are novel sialyltransferase inhibitors, and compositions and methods for treating diseases and/or conditions associated with the activation of sialyltransferase, such as a cancer, an immune disease or an inflammatory disease.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, orZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: The present invention relates to compositions and methods of inhibiting p38 kinase to reduce gene and protein expression of DUX4 and downstream genes regulated by DUX4. The present invention further relates to methods for treating patients suffering from diseases associated with increased expression of DUX4 or expression of an aberrant form of DUX4, such as Facioscapulohumeral muscular dystrophy (FSHD).

Abstract: The invention relates to a compound of formula (I): wherein variables are as defined in the specification. The compound is an inhibitor of an ERK kinase, e.g. ERK1 and/or ERK2 kinase. The invention also relates to the use of the compound and a method for preparing the compound, and a pharmaceutical composition containing the compound.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: Apparatus and methods may be provided that may include a single bracket (e.g., a single universal support or anchor bracket) capable of operably mounting or supporting multiple diverse configurations of system hardware components (e.g., such as solid state drive (SSD) cards) to an existing motherboard or other system support component/surface on or within the same system chassis of an information handling system.

Abstract: An earthquake alarm device, including an alarm lamp and a base. Inside the alarm lamp, there is a power supply module and an earth magnetic field detection module. The earth magnetic field detection module emits a sound and light early warning signal when identifying any earth field abnormality. The vibration sensing module I senses slight vibration and emits a sensing signal I. The vibration sensing module II senses strong vibration and emits a sensing signal II. The control chip II emits sound and light alarm signals after receiving the sensing signal II or the sensing signal I and sound and light early warning signal at the same time. The alarm lamp gives a light alarm after receiving a sound and light early warning signal. The lighting module receives sound and light early warning signals or sound and light alarm signals and provides lighting.

Abstract: An earthquake alarm device, including an alarm lamp and a base. Inside the alarm lamp, there is a power supply module and an earth magnetic field detection module. The earth magnetic field detection module emits a sound and light early warning signal when identifying any earth field abnormality. The vibration sensing module I senses slight vibration and emits a sensing signal I. The vibration sensing module II senses strong vibration and emits a sensing signal II. The control chip i emits sound and light alarm signals after receiving the sensing signal II or the sensing signal I and sound and light early warning signal at the same time. The alarm lamp gives a light alarm after receiving a sound and light early warning signal. The lighting module receives sound and light early warning signals or sound and light alarm signals and provides lighting.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: Systems and methods are disclosed for transitioning a magnetic keyboard between retracted and extended states using a retractable keyboard hinge structure. An information handling system may include a housing having a first housing portion and a second housing portion rotatably coupled by the retractable keyboard hinge structure. The first housing portion may include a magnetic keyboard, and a sliding plate including a plurality of magnets that may be disposed underneath the magnetic keyboard. The retractable keyboard hinge structure may include a first hinge and a first cam. The first hinge and the first cam, when the first housing portion is rotated in relation to the second housing portion, may cause the sliding plate to move in a first linear direction. In response to the sliding plate moving, the plurality of magnets may cause the magnetic keyboard to move in a second linear direction perpendicular to the first linear direction.

Abstract: Disclosed herein are novel sialyltransferase inhibitors, and compositions and methods for treating diseases and/or conditions associated with the activation of sialyltransferase, such as a cancer, an immune disease or an inflammatory disease.

Abstract: Various methods and systems are provided for controlling and shaping the current waveform for a solenoid in a fuel injector that has variable impedance.

Abstract: A system and method are provided for producing radio-frequency (RF) coverage maps for networks of ground stations. The coverage maps are produced from ground station log files that are generated for a particular network of RF radio stations, including an ARINC VHF Data Link Mode 2 (VDLM2) Network. A coverage map regarding interactive communications between aircraft and various ground stations at a particular location therefrom is generated based on actual available operating data including geographic locating of an aircraft, which may be according to Global Positioning Satellite (GPS) system data or other aircraft geolocating data, and Received Signal Strength Indication (RSSI) measurements for the data exchange with the aircraft.

Abstract: Various methods and systems are provided for controlling and shaping the current waveform for a solenoid in a fuel injector that has variable impedance.

Abstract: The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.

Abstract: An endoscopic injection needle device includes a flexible elongate sheath attached to a handle. Disposed within the sheath is drive shaft having a lumen within and a needle at its distal end. The drive shaft is movable longitudinally within the sheath and is attached at its proximal end within the handle to an actuator. Advancing the actuator extends the needle from the distal end of the device. The actuator includes a locking mechanism that locks it in place with the handle when advanced a certain distance. The locking mechanism includes multiple locking positions wherein the exposed length of the needle corresponds to the distance advanced by the actuator at each locking position. Also included in the distal end of the sheath are a spring coil and a collar. The collar is positioned distal to the spring coil and includes a dome shaped distal end that extends beyond the distal end of the sheath. The drive shaft extends through the spring coil and, when retracted, the needle is housed within the collar.

Abstract: The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu-A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.

Abstract: Various methods and systems for identifying defect types on a wafer are provided. One computer-implemented method for identifying defect types on a wafer includes acquiring output of an inspection system for defects detected on a wafer. The output is acquired by different combinations of illumination and collection channels of the inspection system. The method also includes identifying defect types of the defects based on the output acquired by a set of the different combinations. The set of the different combinations is selected based on the defect types to be identified on the wafer and a wafer type of the wafer such that a different set of the different combinations of the illumination and collection channels is used for identifying different defect types on different wafer types.