Abstract: The present disclosure relates to a compound of Formula (I) or a salt, a solvate, an isotopically enriched analog, a tautomer, a polymorph, a stereoisomer thereof, or a mixture of stereoisomers thereof, and their use for treating a tumor. The present disclosure also relates to a compound of Formula (I?) or a pharmaceutically acceptable salt, a solvate, an isotopically enriched analog, a tautomer, a polymorph, a stereoisomer thereof, or a mixture of stereoisomers thereof, and their use for treating a tumor.

Abstract: The invention provides an electric valve including a valve core, an actuating assembly to actuate the valve core and a housing receiving the valve core and the actuating assembly. The housing is provided with a partition plate dividing an internal space of the housing into a first space and a second space. The valve core and the actuating assembly are respectively accommodated in the first and second space and connected with each other via a through hole defined in a centre of the partition plate. The partition plate defines at least one diversion groove communicating with the through hole. Said at least one diversion groove extends through a sidewall of the housing.

Abstract: The present disclosure relates to a compound of Formula (I) or a salt, a solvate, an isotopically enriched analog, a tautomer, a polymorph, a stereoisomer thereof, or a mixture of stereoisomers thereof, and their use for treating a tumor. The present disclosure also relates to a compound of Formula (I?) or a pharmaceutically acceptable salt, a solvate, an isotopically enriched analog, a tautomer, a polymorph, a stereoisomer thereof, or a mixture of stereoisomers thereof, and their use for treating a tumor.

Abstract: A multi-port valve includes a valve housing, a valve core rotatably mounted to the valve housing and a sealing gasket disposed between the valve housing and the valve core. The valve housing defines a plurality of valve ports. The valve core defines a plurality of flow channels. The sealing gasket is provided with a plurality of openings arranged at intervals in a circumferential direction and a plurality of first ribs respectively arranged between adjacent two of the openings. The flow channels extend through an end of the valve core facing the sealing gasket to define a plurality of channel ports; the channel ports are arranged at intervals in a circumferential direction with a plurality of second ribs respectively arranged between adjacent two of the channel ports. each of the first ribs or second ribs forms two wing portions at circumferential sides thereof to make a portion of the first or second rib has a larger circumferential width than other portion thereof.

Abstract: A bifunctional compound, or a pharmaceutically acceptable salt, an isomer, a prodrug, a polymorphic substance or a solvate thereof. The chemical structural formula of the bifunctional compound is represented as formula I, and the bifunctional compound can be used for preventing or treating cancers.

Abstract: An anode catalyst layer with high reversal tolerant capability includes an anode inner catalyst layer close to a proton exchange membrane and an anode outer catalyst layer close to a gas diffusion layer. At least the anode inner catalyst layer contains a reversal tolerant catalyst and a hydrophilic additive. The content of the hydrophilic additive in the anode inner catalyst layer is not less than that of the anode outer catalyst layer, or the water retention capability of the anode inner catalyst layer is not less than that of the anode outer catalyst layer.

Abstract: A multifunctional mixed oxide electrocatalyst material including a metal oxide A with oxygen storage capacity and a metal oxide B with oxygen evolution reaction is prepared by two-steps hydrothermal reactions. The electrocatalyst material is a good free radical scavenger, oxygen evolution reagent and able to alleviate carbon monoxide poisoning on catalyst, when it is applied in a membrane electrode assembly for fuel cells.

Abstract: A compound of general formula (I), a compound of general formula (III) and anti-tumor applications thereof. A series of compounds designed and synthesized have a wide range of pharmacological activities, have the function of degrading specific proteins and/or inhibiting activity, and can be used in related tumor and cancer treatments.

Abstract: The application discloses a multi-way valve including a valve housing and a valve core rotatably mounted in the valve housing. The valve housing defines a plurality of valve ports, the valve core defines a plurality of flow channels, each of which has two ends adapted to be respectively aligned with and in fluid communication with two of the valve ports of the valve housing. A plurality of buffer chambers is formed between the valve housing and the valve core. The buffer chambers are in fluid isolation from each other. The valve core is provided with a plurality of balance holes, each of which is in fluid communication with one of the flow channels. The buffer chambers communicate with the corresponding flow channels through the corresponding balance holes.

Abstract: A flow reversing device is provided for a heating, ventilation, air conditioning, and refrigeration (HVACR) system having a heat exchanger. The flow reversing device included a first flow control device, a second flow control device, a third flow control device, and a fourth flow control device, each flow control device being a two-way flow control device. When the first flow control device and the fourth flow control device are opened and the second flow control device and the third flow control device are closed, a first flow is formed. When the second flow control device and the third flow control device are opened and the first flow control device and the fourth flow control device are closed, a second flow is formed. The first flow and the second flow are in opposite directions.

Abstract: Provided is an anode with surface quantum states and a semiconductor device, which relates to the technical field of organic semiconductor optoelectronic devices. The anode with the surface quantum states is applied to a semiconductor device, including a substrate, a conductive anode, and a surface quantum state generation region arranged in sequence from bottom to top. Holes are directly injected into HOMO energy level of a hole transport layer through charge transfer quantum states on the surface of an anode, and thus the performance of the semiconductor device can be improved.

Abstract: A training model allocation method, an apparatus, a computer device, and a storage medium are provided. The method includes: acquiring hierarchy information, calculating parameter information, and a training data set of a to-be-trained model; dividing the to-be-trained model into sub-models according to the hierarchy information, and allocating each of sub-models to machine nodes in a training cluster; dividing each of sub-models into sub-model slices according to the calculating parameter information, and allocating each of sub-model slices to computing processors of the machine nodes in the training cluster; dividing the training data set into training data subsets according to the calculating parameter information, and allocating each of training data subsets to the computing processors in the training cluster; and training the to-be-trained model according to all computing processors, sub-model slices, and training data subsets in the training cluster.

Abstract: The invention provides an electric valve including a valve core, an actuating assembly to actuate the valve core and a housing receiving the valve core and the actuating assembly. The housing is provided with a partition plate dividing an internal space of the housing into a first space and a second space. The valve core and the actuating assembly are respectively accommodated in the first and second space and connected with each other via a through hole defined in a centre of the partition plate. The partition plate defines at least one diversion groove communicating with the through hole. Said at least one diversion groove extends through a sidewall of the housing.

Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

Abstract: An air volume control valve capable of accurately measuring an air volume is provided. The air volume control valve includes a round-shaped valve body, and a valve blade and an orifice plate provided in the round-shaped valve body, where the orifice plate is located upstream of the valve blade; an upstream pressure tapping port and a downstream pressure tapping port are respectively provided upstream and downstream of the orifice plate; a distance from both the upstream pressure tapping port and the downstream pressure tapping port to the orifice plate is 0.5 times a valve diameter; the valve blade is located downstream of the downstream pressure tapping port; an inlet side of the round-shaped valve body is provided with a convergent duct fitting; and the convergent duct fitting is located at a distance of once the valve diameter upstream of the orifice plate and is tapered along an air flow direction.

Abstract: An air volume control valve capable of accurately measuring an air volume is provided. The air volume control valve includes a round-shaped valve body, and a valve blade and an orifice plate provided in the round-shaped valve body, where the orifice plate is located upstream of the valve blade; an upstream pressure tapping port and a downstream pressure tapping port are respectively provided upstream and downstream of the orifice plate; a distance from both the upstream pressure tapping port and the downstream pressure tapping port to the orifice plate is 0.5 times a valve diameter; the valve blade is located downstream of the downstream pressure tapping port; an inlet side of the round-shaped valve body is provided with a convergent duct fitting; and the convergent duct fitting is located at a distance of once the valve diameter upstream of the orifice plate and is tapered along an air flow direction.

Abstract: An HVACR unit is disclosed. The HVACR unit includes a circuit having a compressor, a first heat exchanger, a second heat exchanger, and an expander. A heat exchanger assembly includes a fan and one of the first heat exchanger and the second heat exchanger, the fan being configured to draw air through the heat exchanger assembly for exchanging thermal energy with a working fluid in the circuit. The frame includes a unit support disposed on a base, the unit support being configured to laterally support the heat exchanger assembly, and the base being configured to vertically support the heat exchanger assembly. A forklift receptacle disposed in the HVACR unit, including one or more channels configured to respectively receive one or more tines of a forklift. The forklift receptacle is overlapped, in a longitudinal direction of the HVACR unit, with a center of mass of the HVACR unit.

Abstract: The present discloses a simulation device and simulation method for liquid sulfur-gas-water multiphase flow and use thereof in a high-temperature and high-pressure gas reservoir with high sulfur content.

Abstract: The present invention provides novel and improved processes for treating a lignocellulosic biomass or technical lignin using ionic liquids to obtain lignin breakdown products and polysaccharide biomass components. Recycling of ionic liquids can be included in the methods of the invention.