Abstract: The present disclosure provides a compound of formula (I) targeting and degrading BCR-ABL protein and its use in the field of antitumor. The compound of formula (I) shows degradation and inhibitory effects on BCR-ABL target protein, which is mainly comprised of four moieties, wherein the first moiety (BCR-ABL-TKIs) is compound moiety with BCR-ABL tyrosine kinase inhibited activity; the second moiety (the LIN) is link units; the third moiety (the ULM) is a small molecule ligand for VHL or CRBN proteases with ubiquitination; and the four moiety (the group A) is carbonyl group that covalently binds to BCR-ABL-TKIs and LIN, and the LIN is further covalently bonded to ULM. A series of compounds designed and synthesized by the present disclosure shows extensive pharmacological effective, which function to degrade BCR-ABL protein and inhibit BCR-ABL effective, and can be utilized for treating relevant tumor.

Abstract: The present disclosure relates to glutarimide skeleton-based compounds of Formula (I) or a salt, an enantiomer, a stereoisomer, a solvate, or a polymorph thereof, and uses thereof. The present disclosure further relates to a pharmaceutical composition comprising, as an active ingredient, the glutarimide skeleton-based compounds of Formula (I), or a salt, an enantiomer, a stereoisomer, a solvate, or a polymorph thereof, and uses thereof. The series of compounds designed and synthesized in the present disclosure can effectively prevent and/or treat a tumor.

Abstract: A microwave shielding plate and a cooking device are disclosed. The microwave shielding plate includes one or more conductive layers, a conductor is provided in each of the conductive layers, and two ends of the conductor are provided with wiring points, so that a shielding section covering the conductive layers is formed when the conductor is coupled into a conductive loop.

Abstract: An aluminum alloy brazing sheet has a 3XXX, 1XXX or 6XXX core, an interliner and a 4XXX brazing layer without added Mg. The interliner has Bi and Mg, the magnesium migrating to the surface of the brazing sheet during brazing and reducing the aluminum oxide to facilitate brazing without flux in a controlled inert atmosphere with reduced oxygen.

Abstract: An anode catalyst layer with high reversal tolerant capability includes an anode inner catalyst layer close to a proton exchange membrane and an anode outer catalyst layer close to a gas diffusion layer. At least the anode inner catalyst layer contains a reversal tolerant catalyst and a hydrophilic additive. The content of the hydrophilic additive in the anode inner catalyst layer is not less than that of the anode outer catalyst layer, or the water retention capability of the anode inner catalyst layer is not less than that of the anode outer catalyst layer.

Abstract: An aluminum alloy brazing sheet has a 3XXX, 1XXX or 6XXX core, an interliner and a 4XXX brazing layer without added Mg. The interliner has Bi and Mg, the magnesium migrating to the surface of the brazing sheet during brazing and reducing the aluminum oxide to facilitate brazing without flux in a controlled inert atmosphere with reduced oxygen.

Abstract: A bifunctional compound, or a pharmaceutically acceptable salt, an isomer, a prodrug, a polymorphic substance or a solvate thereof. The chemical structural formula of the bifunctional compound is represented as formula I, and the bifunctional compound can be used for preventing or treating cancers.

Abstract: A polymyxin B component or salts thereof, and a preparation and application thereof. The polymyxin B component includes six ?,?-diaminobutyric acids respectively at positions 1, 3-5 and 8-9, two threonine residues at positions 2 and 10, a phenylalanine residue at position 6 and a leucine residue at position 7 linked in sequence. The threonine residue at position 10 is linked to the ?,?-diaminobutyric acid at position 4 by an amido bond, and the ?,?-diaminobutyric acid at position 1 is linked to 6-methyloctyl-2-enoyl.

Abstract: A blockchain of transactions may be referenced for various purposes and may be later accessed by interested parties for ledger verification. One example method of operation may comprise one or more of identifying a production date associated with a product, creating a unique code to represent the production date and the product based on a hash of one or more blocks of a blockchain, and forwarding the unique code to a verification server to verify the product.

Abstract: A compound of general formula (I), a compound of general formula (III) and anti-tumor applications thereof. A series of compounds designed and synthesized have a wide range of pharmacological activities, have the function of degrading specific proteins and/or inhibiting activity, and can be used in related tumor and cancer treatments.

Abstract: The present disclosure relates to a compound of Formula (I) or a salt, a solvate, an isotopically enriched analog, a tautomer, a polymorph, a stereoisomer thereof, or a mixture of stereoisomers thereof, and their use for treating a tumor. The present disclosure also relates to a compound of Formula (I?) or a pharmaceutically acceptable salt, a solvate, an isotopically enriched analog, a tautomer, a polymorph, a stereoisomer thereof, or a mixture of stereoisomers thereof, and their use for treating a tumor.

Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

Abstract: The present disclosure discloses a multi-grafting site carbon nanomaterial comprising a structural unit represented by Formula (1), hydroxyl groups and a structural unit represented by Formula (2); wherein R is one or more selected from the group consisting of tolyl, diphenylmethyl, isophorone group and dicyclohexylmethyl;

Abstract: The present disclosure relates to an ER protein regulator compound represented by formula (I) and use thereof. LIN in the compound represented by formula (I) is a linker; ULM is a small-molecule ligand of VHL or CRBN protease having a ubiquitylation function; and group X is CH2, O or NH, and group X is covalently linked to ULM by means of the linker LIN. The designed and synthesized compounds of the present disclosure have wide pharmacological activity, has the function of regulating ER protein and inhibiting the activity of tumors, and can be used for preventing and/or treating diseases and disorders associated with estrogen receptors, or related tumor treatment.

Abstract: A method for suppressing tumor metastasis, in which an effective amount of a compound of formula (I) is administered to a subject in need thereof. Also disclosed is a method of treating cancer, in which an effective amount of a chemotherapy agent and an effective amount of a compound of formula (I) is administered to a subject in need thereof. Further disclosed are pharmaceutical compositions for suppressing tumor metastasis and for treating cancer, each of the compositions containing a compound of formula (I).

Abstract: A method for stabilizing fluorides and arsenic in soil includes: step 1, adding a calcium-containing compound to the soil contaminated by fluorides and arsenic, stirring uniformly, and standing for curing; step 2, adding an iron-containing compound to the mixture obtained in step 1, stirring uniformly, and standing for curing; and step 3, adding water to the mixture obtained in step 2, optionally adding a pH adjusting agent to adjust the gravimetric water content to 30%-40%, and standing for curing. The method uses calcium-containing and iron-containing compounds in a step-by-step manner, makes full use of the advantages of different passivation materials, combines the advantages of all reagents, and establishes an economical, efficient and environmentally friendly method for stabilizing fluorides and arsenic in soil to achieve effective remediation of contaminated soil.

Abstract: Embodiments include predicting transactions by an entity and identifying promotions to offer the entity. Aspects include parsing a plurality of event records corresponding to a plurality of entities respectively. Aspects also include identifying a sequence of events corresponding to the entity and discretizing time durations and event values of the sequence of events into discrete symbolic values. Aspects further include generating a temporal pattern of events in the sequence of events, the temporal pattern including a sequence of transaction-symbols representative of the time duration and the event value of the events in the sequence of events of the entity and predicting a next transaction based on the temporal pattern.

Abstract: Embodiments include predicting transactions by an entity and identifying promotions to offer the entity. Aspects include parsing a plurality of event records corresponding to a plurality of entities respectively. Aspects also include identifying a sequence of events corresponding to the entity and discretizing time intervals and event values of the sequence of events into discrete symbolic values. Aspects further include generating a temporal pattern of events in the sequence of events, the temporal pattern including a sequence of transaction-symbols representative of the time interval and the event value of the events in the sequence of events of the entity and predicting a next transaction based on the temporal pattern.

Abstract: A drug used for treating ischemia and hypoxia-induced tissue necrosis or for improving cardiac function; the drug contains amniotic fluid from a non-human animal and/or an extract thereof, and an optional pharmaceutically acceptable carrier, wherein the amniotic fluid comes from chicken eggs having an embryonic age of 5-12 days, eggs from other birds corresponding to the described developmental period, embryos from rodents having a gestational age of 8-20 days, or embryos from other non-human mammals corresponding to the described developmental period. The drug may promote the growth of human umbilical vein endothelial cells, AC16 cells and chicken embryo fibroblasts, improve cardiac function after myocardial infarction, and promote cardiac cell regeneration after a myocardial infarction.