Abstract: Methods and systems for comparing information obtained during execution of a workload to a set of inefficiency patterns, and determining the workload includes a potential inefficiency when the information matches at least one of the set of inefficiency patterns.

Abstract: Provided herein are methods of encapsulating molecules in milk fat globules and oleosomes, and compositions and pharmaceutical formulations of compositions with molecules encapsulated in milk fat globules and oleosomes.

Abstract: Systems, surrogates, indicators and methods for rapid assessment of sanitation processes are provided. Non-living and non-toxic surrogates applied to a platform or encapsulated in a biological material mounted to a platform are exposed to a sanitation process to be evaluated. Responses to sanitation are measured and quantified using FTIR and chemometrics including principal component analysis (PCA), partial least squares regression (PLSR), loading plots and predictive models. An artificial leaf platform with one or more types of surrogates on one surface and an anchor such as an adhesive film on a second surface is described. Surrogate types include nucleic acid, phage, yeast and algae surrogates. Surrogates may also be attached directly or through a polymer to the platform surface. Surrogates may also be encapsulated or attached to the outside of a biological carrier such as a yeast cell that is free or coupled to the platform.

Abstract: Provided are lipid membrane microcapsules encapsulating or containing bioactives, and methods of production and use.

Abstract: Rechargeable antimicrobial materials that can provide continuous sanitation of contact surfaces or liquids are provided that are based on functionalized sanitization particles that are either freestanding or coupled to a surface film. The sanitization particles have a carrier particle and one or more antimicrobial agents loaded into, adsorbed onto or bonded to each carrier particle. The antimicrobial agents may also be joined to a polymer or particulates of clay or zeolite that are coupled to the carrier. Sanitization particles may also be coupled directly to a film or through a chemical linker. The particles and films provide methods of enhanced inactivation of antibiotic resistant bacteria, inactivation and dissipation of biofilms, and the reduction or elimination of bacterial pathogens from surfaces, medical devices, on food or in food containers.

Abstract: Provided herein are methods for selecting/identifying and/or isolating cancer stem cells from a biological sample or a cell culture sample using a fluorescent glucose analog. Also provided herein are methods for selecting/identifying and/or isolating leukemia stem cells and subpopulations thereof. The present invention is based, in part, on the discovery that cancer stem cells can be selected/identified based upon a lower level of fluorescence of the fluorescent glucose analog compared to non-cancer stem cells and that specific genes are differentially expressed in leukemia stem cells compared to non-leukemia stem cells.

Abstract: Provided are lipid membrane microcapsules encapsulating or containing bioactives, and methods of production and use.

Abstract: Provided herein are methods for selecting/identifying and/or isolating cancer stem cells from a biological sample or a cell culture sample using a fluorescent glucose analog. Also provided herein are methods for selecting/identifying and/or isolating leukemia stem cells and subpopulations thereof. The present invention is based, in part, on the discovery that cancer stem cells can be selected/identified based upon a lower level of fluorescence of the fluorescent glucose analog compared to non-cancer stem cells and that specific genes are differentially expressed in leukemia stem cells compared to non-leukemia stem cells.

Abstract: Provided are methods and devices for the detection of bacteriophages.

Abstract: The present disclosure provides compounds comprising modified oligonucleotides and anti-CD22 antibodies. Certain such modified oligonucleotides conjugated to anti-CD22 antibodies are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.

Abstract: The present invention is directed to a process of disinfecting produce, comprising the steps of associating the produce with one or more photosensitizers selected from the group consisting of gallic acid, fructose, riboflavin, sodium chlorophyllin and photo-porphyrin; and exposing the associated produce and one or more photosensitizers to UV radiation sufficient to cause the one or more photosensitizers to generate one or more free radicals. The produce may be fresh produce and may be selected from fresh vegetable and fruits. The present invention may also be used to treat waste water by adding at least one photosensitizer to waste water ant then expose the waste water to US radiation.

Abstract: The present disclosure provides compounds comprising modified oligonucleotides and anti-CD22 antibodies. Certain such modified oligonucleotides conjugated to anti-CD22 antibodies are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.

Abstract: The present disclosure relates to methods of facilitating bone growth. The method may include positioning a device around at least a portion of a bone exhibiting a defect, the device capable of retaining bone segments and micro-structured particles. The method may also include applying micro-structure particles within the device to the defect, wherein each of the micro-structure particles include at least one pore therein. In addition, the method may include aligning at least a portion of the micro-structure particles and applying a polymer to the particles and solidifying the polymer.

Abstract: A medical implant for drug delivery comprising an inner layer of polymer material including a drug dispersed therein and an outer layer which may then mediate the release of the drug in a controllable manner. The outer layer may adhere and/or penetrate the underlying layer and offer a protective coating along with improved mechanical strength along with the ability to hydrate and become permeable to water and allow for drug release.

Abstract: The present disclosure relates to microcapsules that include a shell material and a core material. The core material of the microcapsules contains an environmentally sensitive luminescent colorant which exhibits characteristics of an emitted wavelength bandwidth, a peak intensity for emission and a time for luminescence decay, one or more of the characteristics capable of changing upon exposure to a given environment, and a luminescent standard which exhibits characteristics of an emitted wavelength bandwidth, a peak intensity for emission and a time for luminescence decay, one or more of the characteristics do not change upon exposure to said given environment.

Abstract: The present disclosure is directed at methods and apparatus to evaluate and monitor healing progress of wound and/or to generate data to modify or identify a treatment protocol. Fluid exudate removed from the wound by a negative pressure therapy device may now be analyzed to identify the progress of wound healing, such as whether healing is progressing in a positive manner or experiencing one or more impediments. The fluid exudates may be specifically analyzed for one or more analytes indicative of one or more of the biochemical reactions that may occur during wound recovery. In addition, one may separately utilize optical sensors integrated into a dressing enclosure, optionally in those dressings employed in a negative pressure therapy device. Such optical sensors may then illuminate the wound and collect information regarding the wound via a light scattering type response.

Abstract: An apparatus and method for treating an ophthalmic lens mold part. The treatment includes formation of ketones on a lens forming surface of the mold part. In some embodiments, the treatment includes exposure of the surface of the lens forming surface to ozone.

Abstract: A medical implant for drug delivery comprising an inner layer of polymer material including a drug dispersed therein and an outer layer which may then mediate the release of the drug in a controllable manner. The outer layer may adhere and/or penetrate the underlying layer and offer a protective coating along with improved mechanical strength along with the ability to hydrate and become permeable to water and allow for drug release.

Abstract: The present disclosure relates to methods of facilitating bone growth. The method may include positioning a device around at least a portion of a bone exhibiting a defect, the device capable of retaining bone segments and micro-structured particles. The method may also include applying micro-structure particles within the device to the defect, wherein each of the micro-structure particles include at least one pore therein. In addition, the method may include aligning at least a portion of the micro-structure particles and applying a polymer to the particles and solidifying the polymer.

Abstract: The present disclosure is directed at methods and apparatus to evaluate and monitor healing progress of wound and/or to generate data to modify or identify a treatment protocol. Fluid exudate removed from the wound by a negative pressure therapy device may now be analyzed to identify the progress of wound healing, such as whether healing is progressing in a positive manner or experiencing one or more impediments. The fluid exudates may be specifically analyzed for one or more analytes indicative of one or more of the biochemical reactions that may occur during wound recovery. In addition, one may separately utilize optical sensors integrated into a dressing enclosure, optionally in those dressings employed in a negative pressure therapy device. Such optical sensors may then illuminate the wound and collect information regarding the wound via a light scattering type response.