Patents by Inventor Nizar Haddad

Nizar Haddad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral dihydrobenzooxaphosphole ligands and synthesis thereof
    Patent number: 10544177
    Abstract: This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: January 28, 2020
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jean-Nicolas Desrosiers, Daniel Robert Fandrick, Nizar Haddad, Guisheng Li, Nitinchandra D. Patel, Bo Qu, Sonia Rodriguez, Chris Hugh Senanayake, Joshua Daniel Sieber, Zhulin Tan, Xiao-Jun Wang, Nathan K. Yee, Li Zhang, Yongda Zhang
  • NOVEL CHIRAL DIHYDROBENZOOXAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF
    Publication number: 20190144475
    Abstract: This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.
    Type: Application
    Filed: January 10, 2019
    Publication date: May 16, 2019
    Inventors: Jean-Nicolas DESROSIERS, Daniel Robert FANDRICK, NIZAR HADDAD, Guisheng LI, Nitinchandra D. PATEL, Bo QU, Sonia RODRIGUEZ, Chris Hugh SENANAYAKE, Joshua Daniel SIEBER, Zhulin TAN, Xiao-Jun WANG, Nathan K. YEE, Li ZHANG, Yongda ZHANG
  • Chiral dihydrobenzooxaphosphole ligands and synthesis thereof
    Patent number: 10221203
    Abstract: This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: March 5, 2019
    Assignee: Boehringer Ingelheim International Gmbh
    Inventors: Jean-Nicolas Desrosiers, Daniel Robert Fandrick, Nizar Haddad, Guisheng Li, Nitinchandra D. Patel, Bo Qu, Sonia Rodriguez, Chris Hugh Senanayake, Joshua Daniel Sieber, Zhulin Tan, Xiao-Jun Wang, Nathan K. Yee, Li Zhang, Yongda Zhang
  • Stereoselective process
    Patent number: 10189776
    Abstract: The invention relates to a method for the stereoselective preparation of compounds of formula (IV).
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: January 29, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Uwe Joerg Ries, Nizar Haddad, Bo Qu
  • STEREOSELECTIVE PROCESS
    Publication number: 20180258031
    Abstract: The invention relates to a method for the stereoselective preparation of compounds of formula (IV).
    Type: Application
    Filed: September 16, 2016
    Publication date: September 13, 2018
    Inventors: Uwe Joerg Ries, Nizar HADDAD, Bo QU
  • NOVEL CHIRAL DIHYDROBENZOOXAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF
    Publication number: 20180155375
    Abstract: This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.
    Type: Application
    Filed: December 6, 2017
    Publication date: June 7, 2018
    Inventors: Jean-Nicolas Desrosiers, Daniel Robert Fandrick, Nizar Haddad, Guisheng Li, Nitinchandra D. Patel, Bo Qu, Sonia Rodriguez, Chris Hugh Senanayake, Joshua Daniel Sieber, Zhulin Tan, Xiao-Jun Wang, Nathan K. Yee, Li Zhang, Yongda Zhang
  • Monophosphorus ligands and their use in cross-coupling reactions
    Patent number: 9096626
    Abstract: Phosphine ligands of the formula Ia, IB and mixtures thereof.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: August 4, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Nizar Haddad, Bo Qu, Sonia Rodriguez, Chris Senanayake, Wenjun Tang, Xudong Wei, Nathan K. Yee
  • Ruthenium catalysts and their use for asymmetric reduction of ketones
    Patent number: 9029540
    Abstract: Disclosed are novel ruthenium compounds of formula (Ia) and (Ib): wherein R1 and the moiety are defined herein. Also disclosed is a process for using these novel ruthenium compounds as catalysts for asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and excellent selectivities.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: May 12, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Nizar Haddad, Heewon Lee, Bo Qu, Sonia Rodriguez, Chris Hugh Senanayake
  • Chiral nitrogen-phosphorus ligands and their use for asymmetric hydrogenation of alkenes
    Patent number: 8946418
    Abstract: The invention relates to a series of novel chiral nitrogen-phosphorus ligands of formulae (Ia) and (Ib): wherein R1-R3 and X are as defined herein. The invention also relates to chiral metal complexes prepared with these chiral nitrogen-phosphorus ligands. The chiral metal complexes are useful as catalysts for carrying out asymmetric hydrogenation.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: February 3, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Nizar Haddad, Bo Qu, Jolaine Savoie, Chris Hugh Senanayake, Xudong Wei
  • NOVEL CHIRAL NITROGEN-PHOSPHORUS LIGANDS AND THEIR USE FOR ASYMMETRIC HYDROGENATION OF ALKENES
    Publication number: 20150018555
    Abstract: The invention relates to a series of novel chiral nitrogen-phosphorus ligands of formulae (Ia) and (Ib): wherein R1-R3 and X are as defined herein. The invention also relates to chiral metal complexes prepared with these chiral nitrogen-phosphorus ligands. The chiral metal complexes are useful as catalysts for carrying out asymmetric hydrogenation.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 15, 2015
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Nizar HADDAD, Bo QU, Jolaine SAVOIE, Chris Hugh SENANAYAKE, Xudong WEI
  • NOVEL RUTHENIUM CATALYSTS AND THEIR USE FOR ASYMMETRIC REDUCTION OF KETONES
    Publication number: 20150005500
    Abstract: Disclosed are novel ruthenium compounds of formula (Ia) and (Ib): wherein R1 and the moiety are defined herein. Also disclosed is a process for using these novel ruthenium compounds as catalysts for asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and excellent selectivities.
    Type: Application
    Filed: June 24, 2014
    Publication date: January 1, 2015
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Nizar HADDAD, Heewon LEE, Bo QU, Sonia RODRIGUEZ, Chris Hugh SENANAYAKE
  • PROCESS FOR THE PREPARATION OF AN HIV INTEGRASE INHIBITOR
    Publication number: 20140094610
    Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I) or salts thereof which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid or salt thereof which is useful in the treatment of HIV infection.
    Type: Application
    Filed: October 3, 2013
    Publication date: April 3, 2014
    Inventors: Wenjie LI, Philomen DECROOS, Keith R. FANDRICK, Joe Ju GAO, Nizar HADDAD, Zhi-Hui LU, Bo QU, Sonia RODRIGUEZ, Chris H. SENANAYAKE, Yongda ZHANG, Wenjun TANG
  • PROCESS FOR THE PREPARATION OF AN HIV INTEGRASE INHIBITOR
    Publication number: 20140094609
    Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I), which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid, which is useful in the treatment of HIV infection.
    Type: Application
    Filed: October 2, 2013
    Publication date: April 3, 2014
    Inventors: Brandon H. Brown, Xiang Wang, Keith R. Fandrick, Joe Ju Gao, Nizar Haddad, Serge R. Landry, Wenjie Li, Zhi-Hui Lu, Bo Qu, Diana C. Reeves, Carl Thibeault, Yongda Zhang
  • Monophosphorus Ligands And Their Use In Cross-Coupling Reactions
    Publication number: 20130137902
    Abstract: Phosphine ligands of the formula Ia, IB and mixtures thereof.
    Type: Application
    Filed: March 31, 2011
    Publication date: May 30, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Nizar Haddad, Bo Qu, Sonia Rodriguez, Chris Senanayake, Wenjun Tang, Xudong Wei, Nathan K. Yee
  • Process for preparing macrocyclic compounds
    Patent number: 8222369
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: July 17, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Fabrice Gallou, Nizar Haddad, Azad Hossain, Suresh R. Kapadia, Jianxiu Liu, Chris H. Senanayake, Xudong Wei, Nathan K. Yee
  • Process for preparing acyclic HCV protease inhibitors
    Patent number: 8101765
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: January 24, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Rogelio Perez Frutos, Nizar Haddad, Suresh R. Kapadia, Jon Charles Lorenz, Anjan Saha, Chris Hugh Senanayake, Xudong Wei
  • Process for preparing acyclic HCV protease inhibitors
    Patent number: 8017771
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: September 13, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Rogelio Perez Frutos, Nizar Haddad, Suresh R. Kapadia, Jon Charles Lorenz, Anjan Saha, Chris Hugh Senanayake, Xudong Wei
  • PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS
    Publication number: 20090326194
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Application
    Filed: September 2, 2009
    Publication date: December 31, 2009
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan BUSACCA, Fabrice GALLOU, Nizar HADDAD, Azad HOSSAIN, Suresh R. KAPADIA, Jianxiu LIU, Chris SENANAYAKE, Xudong WEI, Nathan K. YEE
  • Process for preparing macrocyclic compounds
    Patent number: 7608614
    Abstract: Intermediates of the formula QUIN: and methods for their preparation are described. The intermediate compounds are useful for preparing active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: October 27, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Fabrice Gallou, Nizar Haddad, Azad Hossain, Suresh R. Kapadia, Jianxiu Liu, Chris Senanayake, Xudong Wei, Nathan K. Yee
  • Cycloalkylamidoacid compounds, processes for making and uses thereof
    Patent number: 7550622
    Abstract: The invention relates to the field of pharmaceutics and more specifically to cycloalkylamidoacid compositions useful in the preparation of cycloalkyaminoacids and oxazolidinediones, and processes for making cycloamidoacids X and R are defined herein.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: June 23, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Isabelle Gallou, Nizar Haddad, Chris Senanayake, Xudong Wei, Jinghua Xu