Patents by Inventor Nizar Haddad

Nizar Haddad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing macrocyclic compounds
    Patent number: 7544798
    Abstract: Disclosed is a multi-step process for preparing a macrocyclic compound of the formula (I): wherein Q is a radical of the following formula: and the other variables are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: June 9, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Vittorio Farina, Fabrice Gallou, Nizar Haddad, Xiao-jun Wang, Xudong Wei, Jinghua Xu, Yibo Xu, Nathan K. Yee, Li Zhang
  • PROCESS FOR PREPARING ACYCLIC HCV PROTEASE INHIBITORS
    Publication number: 20090124809
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Application
    Filed: January 16, 2009
    Publication date: May 14, 2009
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Carl Alan BUSACCA, Rogelio Perez FRUTOS, Nizar HADDAD, Suresh R. KAPADIA, Jon Charles LORENZ, Anjan SAHA, Chris Hugh SENANAYAKE, Xudong WEI
  • PROCESS FOR PREPARING ACYCLIC HCV PROTEASE INHIBITORS
    Publication number: 20090124808
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Application
    Filed: January 16, 2009
    Publication date: May 14, 2009
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Carl Alan BUSACCA, Rogelio Perez FRUTOS, Nizar HADDAD, Suresh R. KAPADIA, Jon Charles LORENZ, Anjan SAHA, Chris Hugh SENANAYAKE, Xudong WEI
  • Process for preparing acyclic HCV protease inhibitors
    Patent number: 7514557
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: April 7, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Rogelio Perez Frutos, Nizar Haddad, Suresh R. Kapadia, Jon Charles Lorenz, Anjan Saha, Chris Hugh Senanayake, Xudong Wei
  • Process for preparing macrocyclic compounds
    Publication number: 20080177029
    Abstract: Disclosed is a multi-step process for preparing a macrocyclic compound of the formula (I): wherein Q is a radical of the following formula: and the other variables are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Application
    Filed: February 1, 2007
    Publication date: July 24, 2008
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Carl Alan Busacca, Vittorio Farina, Fabrice Gallou, Nizar Haddad, Xiao-Jun Wang, Xudong Wei, Jinghua Xu, Yibo Xu, Nathan K. Yee, Li Zhang
  • Process of making di-aryl urea compounds
    Patent number: 7265222
    Abstract: Disclosed is a process of making compounds of formula(I): wherein R1, R2, R3, R4 and Ra of formula(I) are defined herein. The product compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation. Also disclosed are intermediates useful in making such compounds.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: September 4, 2007
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Nizar Haddad, Xudong Wei, Chris Hugh Senanayake, Jinghua Xu, Nathan Yee
  • Dipeptide synthesis
    Patent number: 7186827
    Abstract: Disclosed are processes of making dipeptide compounds of formula(I) as further described in the detailed description section:
    Type: Grant
    Filed: October 27, 2004
    Date of Patent: March 6, 2007
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Carl Alan Busacca, Nizar Haddad, Suresh R. Kapadia, Lana Smith Keenan, Jon Charles Lorenz, Chris Hugh Senanayake, Xudong Wei
  • Process for preparing macrocyclic compounds
    Patent number: 7148347
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: December 12, 2006
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Joerg Brandenburg, Kai Donsbach, Hans-Dieter Ecker, Rogelio Perez Frutos, Fabrice Gallou, Dieter Gutheil, Nizar Haddad, Robert Hagenkoetter, Dirk Kemmer, Jutta Kroeber, Thomas Nicola, Juergen Schnaubelt, Michael Schul, Robert Donald Simpson, Xudong Wei, Eric Winter, Yibo Xu, Nathan K. Yee
  • PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS
    Publication number: 20060205638
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Application
    Filed: March 6, 2006
    Publication date: September 14, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Carl Busacca, Fabrice Gallou, Nizar Haddad, Azad Hossain, Suresh Kapadia, Jianxiu Liu, Chris Senanayake, Xudong Wei, Nathan Yee
  • Process for preparing acyclic HCV protease inhibitors
    Publication number: 20050267151
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Application
    Filed: May 23, 2005
    Publication date: December 1, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Carl Busacca, Rogelio Frutos, Nizar Haddad, Suresh Kapadia, Jon Lorenz, Anjan Saha, Chris Senanayake, Xudong Wei
  • Process for preparing macrocyclic compounds
    Publication number: 20050209135
    Abstract: Disclosed is a multi-step process for preparing a macrocyclic compound of the formula (I): wherein Q is a radical of the following formula: and the other variables are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Application
    Filed: March 11, 2005
    Publication date: September 22, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Carl Busacca, Vittorio Farina, Fabrice Gallou, Nizar Haddad, Xiao-Jun Wang, Xudong Wei, Jinghua Xu, Yibo Xu, Nathan Yee, Li Zhang
  • Dipeptide synthesis
    Publication number: 20050113572
    Abstract: Disclosed are processes of making dipeptide compounds of formula(I) as further described in the detailed description section:
    Type: Application
    Filed: October 27, 2004
    Publication date: May 26, 2005
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Carl Busacca, Nizar Haddad, Suresh Kapadia, Lana Smith Keenan, Jon Lorenz, Chris Senanayake, Xudong Wei
  • Cycloalkylamidoacid compounds, processes for making and uses thereof
    Publication number: 20050085544
    Abstract: The invention relates to the field of pharmaceutics and more specifically to novel cycloalkylamidoacid compositions useful in the preparation of cycloalkyaminoacids and oxazolidinediones, and processes for making cycloamidoacids.
    Type: Application
    Filed: August 12, 2004
    Publication date: April 21, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Isabelle Gallou, Nizar Haddad, Chris Senanayake, Xudong Wei, Jinghua Xu
  • Process for preparing macrocyclic compounds
    Publication number: 20050049187
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Application
    Filed: April 6, 2004
    Publication date: March 3, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Joerg Brandenburg, Kai Donsbach, Hans-Dieter Ecker, Rogelio Frutos, Fabrice Gallou, Dieter Gutheil, Nizar Haddad, Robert Hagenkoetter, Dirk Kemmer, Jutta Kroeber, Thomas Nicola, Juergen Schnaubelt, Michael Schul, Robert Simpson, Xudong Wei, Eric Winter, Yibo Xu, Nathan Yee
  • Process of making di-aryl urea compounds
    Publication number: 20040266767
    Abstract: Disclosed is a process of making compounds of formula(I): 1
    Type: Application
    Filed: June 30, 2004
    Publication date: December 30, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Nizar Haddad, Xudong Wei, Chris Hugh Senanayake, Jinghua Xu, Nathan Yee
  • Process of making substituted pyrazoles
    Patent number: 6407238
    Abstract: Disclosed is a process of making substituted pyrazoles from substituted benzophenone hydrazones with a variety of 1,3-bifunctional substrates under acid conditions. The pyrazole compounds are useful for making pharmaceutical compounds.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: June 18, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: James A. Baron, Vittorio Farina, Nizar Haddad