Abstract: Disclosed is a polymer composite (polyplex) that contains nucleic acid, a cationic polymer, and an anionic polymer. The anionic polymer covers the surface of the composite comprising the cationic polymer and nucleic acid, has a negative charge at neutral pH, and can change so as to have a positive charge at mildly acidic pH.

Abstract: The present invention relates to a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polyamino acid chain block, wherein the hydrophilic polymer chain block is covalently bound to one end of the main chain of the polyamino acid chain block, and the hydrophobic group is covalently bound to the side chains of not less than 10% and not greater than 70% of amino acid repeating units in the polyamino acid chain block. This block copolymer forms a stable aggregate with siRNA, a small-molecule nucleic acid, under a physiological condition.

Abstract: Disclosed is a composition for the delivery of nucleic acid to target cells or tissues, which comprises a polycationically charged polymer as a carrier of nucleic acid. The polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula —NH—(CH2)a—(NH(CH2)2)e—NH2 (wherein a and e independently denote an integer of 1 to 5) which is connected to the main chain either directly or via a linker. The disclosed composition has low toxicity, and has a high efficiency in introducing nucleic acid into cells.

Abstract: A semiconductor laser assembly includes a substrate 10 having a first mount surface 10a and a second mount surface 10b, and a submount 3 which is mounted on the first mount surface 10a and which is separate from a monitoring photodiode 4. A laser diode 1 is mounted on the submount 3. The monitoring photodiode 4 is mounted on the second mount surface 10b, and an electrode 4a formed on the monitoring photodiode 4 is used as a relay electrode for a metal wire 5a connected to an upper-surface electrode of the laser diode 1.

Abstract: Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition, and a gene therapy agent, each of which uses the complex. The polyion complex is characterized by comprising: a block copolymer composed of a polyethylene glycol moiety and a polycation moiety having a thiol group as a side chain at the terminus; and siRNA.

Abstract: Facing no ethical obstacle and easily to be isolated, multipotent concretely mesenchymal stem cells (MSCs) are one of the most powerful tools in reconstructive medicine. Here the inventors introduced 3D multicelluar spheroids culture construction based on photolithography and micropatterning techniques to improve multipotent differentiation efficiency of MSCs to adult cells. This invention, the 3D spheroid cultured construction for MSCs, leads to great improve of the differentiation efficiency. This invention relates to a cultured cell construct comprising a support; at least one island on the support; a hydrophilic and cytophobic substance applied on the surface of said support so as to encircle the island; and a spheroid which is derived from MSCs, said spheroid being in contact with the island.

Abstract: A direct-type backlight device for a non-self-luminous image display panel has a light-emitting area corresponding to a display area of the image display panel. The light-emitting area is arranged by combining a plurality of backlight substrates each of which is provided with (i) a color sensor for detecting an incident light intensity and (ii) red, green, and blue LEDs whose respective light intensities are controlled in accordance with a detection result obtained by the color sensor. This arrangement allows reduction of brightness unevenness entirely in the light-emitting area of the backlight device.

Abstract: The combined use of a TGF-? signaling inhibitor and an antitumor active substance or an imaging agent modified by a drug-encapsulating macromolecular micelle, or the like, is provided. The selective delivery capability of the antitumor active substance or the imaging agent to the target is improved, increasing the antitumoral activity in the target.

Abstract: The invention discloses a coordination compound comprising (1,2-diaminocyclohexane)platinum (II) moiety and poly(ethylene glycol)-block-poly(glutamic acid) copolymer moiety; and its use as an anti-cancer agent. The characteristic feature lies in the use of a copolymer whose poly(glutamic acid) segment has a chain length consisting of, on an average, less than 35 repeating units.

Abstract: It is an object of the present invention to provide: a polyion complex that sufficiently retains a photosensitizing substance in serum and is excellent in terms of structural stability; a nucleic acid polyplex as a constituent thereof; and a device and a kit for delivering a nucleic acid into a cell. The nucleic acid polyplex of the present invention comprises a cationic polymer represented by general formula (1) and a nucleic acid. The polyion complex of the present invention comprises the nucleic acid polyplex of the present invention and an anionic photosensitizing substance.

Abstract: A direct-type backlight device for a non-self-luminous image display panel has a light-emitting area corresponding to a display area of the image display panel. The light-emitting area is arranged by combining a plurality of backlight substrates each of which is provided with (i) a color sensor for detecting an incident light intensity and (ii) red, green, and blue LEDs whose respective light intensities are controlled in accordance with a detection result obtained by the color sensor. This arrangement allows reduction of brightness unevenness entirely in the light-emitting area of the backlight device.

Abstract: A composition for the delivery of nucleic acid to target cells or tissues, which comprises polycationically charged polymer as a carrier of nucleic acid is provided. Said polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula —NH—(CH2)a—(NH(CH2)2)e—NH2 (wherein a and e independently denote an integer of 1 to 5) which is connected to said main chain either directly or via a linker. This composition is low-toxic, and has a high efficiency in introducing nucleic acid into cells.

Abstract: A semiconductor laser device includes a first lead having a plate-like mounting portion on which a semiconductor laser chip is mounted and a lead portion extending from the mounting portion, a second lead extending along the lead portion of the first lead, and a retention portion made of an insulative material that integrally retains the first lead and the second lead. The mounting portion of the first lead has a back surface exposed from the retention portion, and the first lead further has a tie bar portion projecting from the mounting portion along the back surface of the mounting portion.

Abstract: A coordinate complex of diaminocyclohexane platinum (II) with a block copolymer comprising a poly(ethylene glycol) segment and a poly(carboxylic acid) segment is provided. The complex can be effectively used in treatments for tumors, in particular malignant tumors.

Abstract: A first reflective surface is disposed on the optical axis of monitor light emitted from a semiconductor laser element, and a second reflective surface is disposed on an inner surface of a lid portion. The first reflective surface is so inclined that the monitor light traveling on the optical axis is reflected on the first reflective surface and is then reflected on the second reflective surface so as to strike, as a second reflected light, a light-receiving surface of a light-receiving element. The light-receiving surface is thus struck not only by the monitor light traveling off the optical axis directly from semiconductor laser element but also by the second reflected light, which has higher intensity than the light traveling off the optical axis.

Abstract: Provided is a complex comprising cisplatin encapsulated therein in a form in which a chlorine ion thereof is ligand-exchanged with a carboxyl anion of a block copolymer comprising poly(ethylene glycol)-poly(glutamic acid). This complex can be a medicinal preparation to which a novel dosage form decreased in toxicity can be applied.

Abstract: A semiconductor laser device includes a first lead having a plate-like mounting portion on which a semiconductor laser chip is mounted and a lead portion extending from the mounting portion, a second lead extending along the lead portion of the first lead, and a retention portion made of an insulative material that integrally retains the first lead and the second lead. The mounting portion of the first lead has a back surface exposed from the retention portion, and the first lead further has a tie bar portion projecting from the mounting portion along the back surface of the mounting portion.

Abstract: The invention relates to a polymeric micellar structure which comprising an ionic porphyrin dendrimer represented by general formula (1): q(c)PM (where q represents the number of charged atoms on the periphery of the dendrimer; c represents a negative (?) or positive (+) charge; and PM is represented by the following general formula (2): wherein M represents two hydrogen atoms or a metal atom, R1, R2, R3 and R4 are the same or different and represents hydrogen or identical or different aryl ether dendrosubunits, provided that at least one of R1, R2, R3 and R4 represent an aryl ether dendrosubunits and that each aryl ether dendrosubunit has an anionic or cationic group at the end optionally though a spacer molecule chain.

Abstract: A semiconductor laser device according to the present invention includes a first lead portion having a mounting portion on which a semiconductor laser chip is mounted, a second lead portion for an electrode, and a resin portion for fixing the first and second lead portions. The second lead portion is provided with an engagement portion engaging with the resin portion in the longitudinal direction of the second lead portion, and extends straight within the resin portion.

Abstract: A base frame, a laser device mounting frame, and a lead frame are formed by stamping and bending one metal plate. A reference plane is constituted by reference plane portions of the flat base frame, and metal plates for heat dissipation and reinforcement are further attached to the reference plane to provide high strength and heat dissipation though the present apparatus is a flame type laser apparatus. Also, a laser device is mounted on the laser device mounting frame, and the surrounding thereof except the light emitting side is molded with a mold resin. This eliminates the need for a cap for protecting the laser device and a wire, and enables collective production. More specifically, collective mass production is enabled by forming a frame by stamping out from one metal plate and molding the frame with resin without use of a cap.