Patents by Inventor Nobuo Hanai

Nobuo Hanai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF PRODUCING ANTIBODIES WITH N-GLYCOSIDE-LINKED SUGAR CHAINS LACKING FUCOSYLATION
    Publication number: 20200017593
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: July 22, 2019
    Publication date: January 16, 2020
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Nobuo HANAI, Kazuyasu NAKAMURA, Emi HOSAKA, Motoo YAMASAKI, Kazuhisa UCHIDA, Toyohide SHINKAWA, Susumu IMABEPPU, Yutaka KANDA, Naoko YAMANE, Hideharu ANAZAWA
  • ANTIBODY COMPOSITION-PRODUCING CELL
    Publication number: 20190360015
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: January 29, 2019
    Publication date: November 28, 2019
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Method of modulating the activity of functional immune molecules
    Patent number: 10233247
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: March 19, 2019
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Antibody composition-producing cell
    Patent number: 10233475
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: March 19, 2019
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • METHOD OF MODULATING THE ACTIVITY OF FUNCTIONAL IMMUNE MOLECULES
    Publication number: 20170240647
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 16, 2017
    Publication date: August 24, 2017
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Nobuo HANAI, Kazuyasu NAKAMURA, Emi HOSAKA, Motoo YAMASAKI, Kazuhisa UCHIDA, Toyohide SHINKAWA, Susumu IMABEPPU, Yutaka KANDA, Naoko YAMANE, Hideharu ANAZAWA
  • Method of modulating the activity of functional immune molecules
    Patent number: 9637545
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: May 2, 2017
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • ANTIBODY COMPOSITION-PRODUCING CELL
    Publication number: 20160348145
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: July 5, 2016
    Publication date: December 1, 2016
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yutaka KANDA, Mitsuo SATOH, Kazuyasu NAKAMURA, Kazuhisa UCHIDA, Toyohide SHINKAWA, Naoko YAMANE, Emi HOSAKA, Kazuya YAMANO, Motoo YAMASAKI, Nobuo HANAI
  • Antibody composition-producing cell
    Patent number: 9409982
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependant cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: August 9, 2016
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • ANTIBODY COMPOSITION-PRODUCING CELL
    Publication number: 20150112046
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependant cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: October 22, 2014
    Publication date: April 23, 2015
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yutaka KANDA, Mitsuo SATOH, Kazuyasu NAKAMURA, Kazuhisa UCHIDA, Toyohide SHINKAWA, Naoko YAMANE, Emi HOSAKA, Kazuya YAMANO, Motoo YAMASAKI, Nobuo HANAI
  • Antibody composition-producing cell
    Patent number: 8895266
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: November 25, 2014
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • METHOD OF MODULATING THE ACTIVITY OF FUNCTIONAL IMMUNE MOLECULES
    Publication number: 20140234300
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: February 5, 2014
    Publication date: August 21, 2014
    Applicant: Kyowa Hakko Kirin Co., Ltd
    Inventors: Nobuo HANAI, Kazuyasu NAKAMURA, Emi HOSAKA, Motoo YAMASAKI, Kazuhisa UCHIDA, Toyohide SHINKAWA, Susumu IMABEPPU, Yutaka KANDA, Naoko YAMANE, Hideharu ANAZAWA
  • Method of modulating the activity of functional immune molecules
    Patent number: 8679491
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: March 25, 2014
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method for producing recombinant antibody and antibody fragment thereof
    Patent number: 8632996
    Abstract: A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: January 21, 2014
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Kenya Shitara, Nobuo Hanai, Emi Shoji, Mikiko Sakurada, Akiko Furuya, Kazuyasu Nakamura, Rinpei Niwa, Kenji Shibata, Motoo Yamasaki
  • Cells with altered fucosylation and producing antibodies therefrom
    Patent number: 8367407
    Abstract: The present invention relates to a cell and mammal in which GDP-mannose 4,6-dehydratase is knocked-out. The cell and mammal are useful for the production of an antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, such as an antibody useful for treating various diseases. The cell and mammal are also useful for the production of a fragment of the antibody, and a fusion protein having the Fc region of the antibody.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: February 5, 2013
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Antibody composition-producing cell
    Patent number: 8329443
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: December 11, 2012
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • GENE RECOMBINANT ANTIBODY AND ANTIBODY FRAGMENT THEREOF
    Publication number: 20120276090
    Abstract: A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
    Type: Application
    Filed: June 8, 2012
    Publication date: November 1, 2012
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Kenya SHITARA, Nobuo HANAI, Emi SHOJI, Mikiko SAKURADA, Akiko FURUYA, Kazuyasu NAKAMURA, Rinpei NIWA, Kenji SHIBATA, Motoo YAMASAKI
  • Method for treating the Th2-mediated disease
    Patent number: 8197814
    Abstract: A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: June 12, 2012
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Kenya Shitara, Nobuo Hanai, Emi Shoji, Mikiko Sakurada, Akiko Furuya, Kazuyasu Nakamura, Rinpei Niwa, Kenji Shibata, Motoo Yamasaki
  • Glycoengineered, recombinant antibody
    Patent number: 8158760
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: April 17, 2012
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Antibody composition exhibiting cellular cytotoxicity due to glycosylation and containing ganglioside GM2 binding antibody
    Patent number: 8110195
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody binding to ganglioside GM2, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: February 7, 2012
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Motoo Yamasaki, Nobuo Hanai, Emi Hosaka, Kazuya Yamano
  • Anti-il-5 antibody composition exhibiting cellular cytotoxicity due to glycosylation
    Patent number: 8101185
    Abstract: The present invention relates to a cell for the production of an anti-IL-5 antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: January 24, 2012
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Motoo Yamasaki, Nobuo Hanai, Emi Hosaka, Kazuya Yamano