Patents by Inventor Nobuo Hanai

Nobuo Hanai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166305
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166301
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166300
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166302
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the liker an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Anti-fibroblast growth factor-8 monoclonal antibody
    Patent number: 7241568
    Abstract: A method for preventing or treating a disease, comprising administering to human or animal in need of such prevention or treatment an effective amount of a monoclonal antibody which specifically binds to FGF-8 and inhibits FGF-8 activity.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: July 10, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Nobuo Hanai, Motoo Yamasaki, Akiko Furuya, Akira Tanaka, Kenya Shitara, Naoki Shimada, Kazuyasu Nakamura, Maiko Hirota
  • Method of treating atopic dermatitis using antibody against human interleukin-5 receptor alpha chain
    Patent number: 7238354
    Abstract: The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor ? chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized antibodies, a method for detecting an interleukin-5 receptor ? chain immunologically by means of these antibodies, as well as a method for diagnosing and treating diseases such as chronic bronchial asthma by means of the monoclonal antibodies and humanized antibodies. The present invention is useful for diagnosis or treatment of diseases such as chronic bronchial asthma.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: July 3, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masamichi Koike, Akiko Furuya, Kazuyasu Nakamura, Akihiro Iida, Hideharu Anazawa, Nobuo Hanai, Kiyoshi Takatsu
  • Method of modulating the activity of functional immune molecules
    Patent number: 7214775
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecules, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having promoted activity.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: May 8, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Process for producing humanized chimera antibody
    Publication number: 20070073043
    Abstract: A humanized chimera antibody, a pharmaceutical composition comprising a humanized chimera antibody and a pharmaceutically acceptable carrier, and a method of treating cancer which comprises administering to a patient a pharmaceutically acceptable amount of the humanized chimera antibody, are disclosed.
    Type: Application
    Filed: September 19, 2005
    Publication date: March 29, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Kenya Shitara, Nobuo Hanai, Mamoru Hasegawa, Hiromasa Miyaji, Yoshihisa Kuwana
  • Method of treating allergy using antibody against human interleukin-5 receptor alpha chain
    Publication number: 20070048304
    Abstract: The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor ? chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized antibodies, a method for detecting an interleukin-5 receptor ? chain immunologically by means of these antibodies, as well as a method for diagnosing and treating diseases such as chronic bronchial asthma by means of the monoclonal antibodies and humanized antibodies. The present invention is useful for diagnosis or treatment of diseases such as chronic bronchial asthma.
    Type: Application
    Filed: November 13, 2006
    Publication date: March 1, 2007
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masamichi Koike, Akiko Furuya, Kazuyasu Nakamura, Akihiro Iida, Hideharu Anazawa, Nobuo Hanai, Kiyoshi Takatsu
  • Method of treatment by administering an antibody to human interleukin-5 receptor ? chain
    Patent number: 7179464
    Abstract: The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor ? chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized antibodies, a method for detecting an interleukin-5 receptor ? chain immunologically by means of these antibodies, as well as a method for diagnosing and treating diseases such as chronic bronchial asthma by means of the monoclonal antibodies and humanized antibodies. The present invention is useful for diagnosis or treatment of diseases such as chronic bronchial asthma.
    Type: Grant
    Filed: October 29, 2002
    Date of Patent: February 20, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Masamichi Koike, Akiko Furuya, Kazuyasu Nakamura, Akihiro Iida, Hideharu Anazawa, Nobuo Hanai, Kiyoshi Takatsu
  • ?,2,8-sialyltransferase
    Patent number: 7163791
    Abstract: The invention provides a novel ?-2,8-sialyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the ?-2,8-sialyltransferase, a method of detecting, or suppressing the production of ?-2,8-sialyltransferase by using the cDNA, a recombinant vector containing the DNA as an insert and cells harboring the recombinant vector as well as methods of preparing same. The ?-2,8-sialyltransferase of the invention is useful, for example, in the production of carbohydrate chains having a useful physiological activity, for example the ganglioside GD3, and modifications thereof.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: January 16, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Katsutoshi Sasaki, Kazumi Miura, Nobuo Hanai, Tatsunari Nishi
  • Antibody Composition-Producing Cell
    Publication number: 20070010009
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: April 13, 2006
    Publication date: January 11, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • ALPHA-1,3-FUCOSYLTRANSFERASE
    Publication number: 20060246468
    Abstract: The invention provides a novel species of ?-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the ?-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the ?-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The ?-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
    Type: Application
    Filed: February 10, 2006
    Publication date: November 2, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Katsutoshi Sasaki, Kazumi Miura, Nobuo Hanai, Tatsunari Nishi
  • ?-1,3-fucosyltransferase
    Patent number: 7094530
    Abstract: The invention provides a novel species of ?-1,3-fucosyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the ?-1,3-fucosyltransferase, a method of detecting, or inhibiting the production of, the ?-1,3-fucosyltransferase which involves the use of the cDNA, a recombinant vector containing the DNA as an insert, a cell harboring the recombinant vector, and a method of producing same. The ?-1,3-fucosyltransferase of the invention is useful in the production of carbohydrate chains having useful physiological activity, for example sialyl Lewis x, and modifications thereof.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: August 22, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Katsutoshi Sasaki, Kazumi Miura, Nobuo Hanai, Tatsunari Nishi
  • Anti-human VEGF receptor FLT-1 monoclonal antibody
    Patent number: 7052693
    Abstract: The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and an antibody or peptide which inhibits binding of human VEGF to human VEGF receptor Flt-1. It also provides a means for the diagnosis or treatment of diseases in which their morbid states progress by abnormal angiogenesis, such as proliferation or metastasis of solid tumors, arthritis in rheumatoid arthritis, diabetic retinopathy, retinopathy of prematurity, psoriasis, and the like.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: May 30, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kenya Shitara, Mikito Ito, Nobuo Hanai, Yoko Kawada, Kazuyasu Nakamura, Masabumi Shibuya
  • Method of treating cancer including administering a human chimeric antibody specific for the ganglioside GD3
    Patent number: 7045129
    Abstract: A humanized chimera antibody, a pharmaceutical composition comprising a humanized chimera antibody and a pharmaceutically acceptable carrier, and a method of treating cancer which comprises administering to a patient a pharmaceutically acceptable amount of the humanized chimera antibody, are disclosed.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: May 16, 2006
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kenya Shitara, Nobuo Hanai, Mamoru Hasegawa, Hiromasa Miyaji, Yoshihisa Kuwana
  • Antibody composition-producing cell
    Publication number: 20060078990
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: November 28, 2005
    Publication date: April 13, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Antibody composition-producing cell
    Publication number: 20060078991
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: November 28, 2005
    Publication date: April 13, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Antibody composition-producing cell
    Publication number: 20060063254
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: September 6, 2005
    Publication date: March 23, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Antibody composition-producing cell
    Publication number: 20060064781
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: October 3, 2005
    Publication date: March 23, 2006
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai