Abstract: The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.

Abstract: The present invention provides the compound, 3-[(1S,2S)-1-[5-[(4S)-2,2-Dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a pharmaceutically acceptable salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound.

Abstract: The present invention provides the compound, 3-[(1S,2S)-1-[5-[(4S)-2,2-Dimethyloxan-4-yl]-2-(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a pharmaceutically acceptable salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound.

Abstract: The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.

Abstract: A water jet peening device includes a sealed vessel provided to cover a surface of a welded portion, and adapted to be in a sealed state where an internal pressure is higher than an outside, a jet nozzle adapted to jet high-pressure water to create a cavitation bubble toward the surface of the welded portion, inside the sealed vessel, and a pressure control hole adapted to be able to adjust the internal pressure of the sealed vessel. The water jet peening device can efficiently reform a tensile residual stress on the surface of the welded portion to a compressive residual stress.

Abstract: The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.

Abstract: A method of evaluating a residual stress including a condition setting step of setting a processing condition of water jet peening for a processing target; an analysis step of analyzing a jet flow when a fluid is injected from a nozzle model to a processing target model in accordance with the processing condition, and obtaining a void fraction which is a volume fraction of babbles contained in a unit volume of the fluid, and a collapse fraction, which is a volume fraction of the bubbles which collapse in a unit time in the unit volume of the fluid, at each position on a surface of the processing target model; an impact pressure correlation value calculating step of obtaining an impact pressure correlation value, which is a product of the void fraction and the collapse fraction at each position; an experimental value acquisition step of obtaining an impact pressure experimental value.

Abstract: A plastically deformable almen strip is held under a predetermined underwater environment in which water jet peening is carried out, and a result of providing compressive residual stress in the water jet peening is confirmed by jetting water jet to the almen strip.

Abstract: A condition setting process of determining peening conditions for water jet peening on a peening target object, an analysis process of analyzing a jet when a liquid is jetted from a nozzle model to a peening target object model and obtaining a void rate that is a volume rate of air bubbles contained in a unit volume of the liquid and a collapse rate that is a volume of the air bubbles collapsing in a unit time in the unit volume of the liquid in each position on a surface of the peening target object model, a shock pressure correlation value calculation process of obtaining a shock pressure correlation value that is a product of the void rate and the collapse rate in each position, and a range calculation process of obtaining an effective processing range in which the shock pressure correlation value on the surface of the peening target object model is greater than a predetermined value, based on the shock pressure correlation value in each position.

Abstract: A water jet peening device includes a sealed vessel provided to cover a surface of a welded portion, and adapted to be in a sealed state where an internal pressure is higher than an outside, a jet nozzle adapted to jet high-pressure water to create a cavitation bubble toward the surface of the welded portion, inside the sealed vessel, and a pressure control hole adapted to be able to adjust the internal pressure of the sealed vessel. The water jet peening device can efficiently reform a tensile residual stress on the surface of the welded portion to a compressive residual stress.

Abstract: The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, chronic renal failure, chronic kidney disease, and arteriosclerosis associated with vascular calcification comprising the compound as an active ingredient, and a method for prevention and/or treatment.

Abstract: A radiation shielding method and a device, and a method of processing a structure, in which a first radiation-shielded region (A1) is provided by disposing a first radiation-shielding device (100) outside a nuclear reactor vessel (41), a neutron flux detector (77) is moved into the radiation-shielded region (A1) through a conduit tube (65) by moving a thimble tube (68) from the nuclear reactor vessel (41), and an inspection/repair work of the nuclear reactor vessel (41) is then performed, so that an amount of radiation delivered to a worker can be easily and sufficiently reduced.

Abstract: It is possible to improve the workability and the stress corrosion resistance by easily performing a repairing operation in a nozzle repairing method and a nuclear reactor vessel. The repairing method includes: removing a first connection portion ((trepanned portion) 208) with respect to an in-core instrument tube (204) in a groove-welding portion (206); removing the in-core instrument tube (204) from a lower mirror (66); leaving and grooving a second connection portion ((existing welding portion) 211) with respect to the lower mirror (66) in the groove-welding portion (206); inserting a new in-core instrument tube (204A) into an attachment hole (203); and groove-welding (so as to form a new groove-welding portion (213)) the inner side of the lower mirror (66) so as to fix the new in-core instrument tube (204A).

Abstract: The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, chronic renal failure, chronic kidney disease, and arteriosclerosis associated with vascular calcification comprising the compound as an active ingredient, and a method for prevention and/or treatment.

Abstract: A plastically deformable almen strip is held under a predetermined underwater environment in which water jet peening is carried out, and a result of providing compressive residual stress in the water jet peening is confirmed by jetting water jet to the almen strip.

Abstract: A condition setting process of determining peening conditions for water jet peening on a peening target object, an analysis process of analyzing a jet when a liquid is jetted from a nozzle model to a peening target object model and obtaining a void rate that is a volume rate of air bubbles contained in a unit volume of the liquid and a collapse rate that is a volume of the air bubbles collapsing in a unit time in the unit volume of the liquid in each position on a surface of the peening target object model, a shock pressure correlation value calculation process of obtaining a shock pressure correlation value that is a product of the void rate and the collapse rate in each position, and a range calculation process of obtaining an effective processing range in which the shock pressure correlation value on the surface of the peening target object model is greater than a predetermined value, based on the shock pressure correlation value in each position.

Abstract: An object of the present invention is to provide a prismatic secondary cell 1 having a structure that makes it easy to inject an electrolytic solution into a cell can 2 and seal the cell can. The prismatic secondary cell 1 is configured so that an electrode group 4 is housed in the cell can 2 and that an opening 2a in the cell can 2 is sealed with a cell lid 3. The prismatic secondary cell 1 includes a solution injection section 7 and a plug section 8. The solution injection section 7 has a plurality of through-holes 21, 22 that penetrate the cell lid 3 and are positioned adjacent to each other. The plug section 8 is attached to the solution injection section 7 to integrally seal the through-holes 21, 22.

Abstract: [Problem] To facilitate mounting of a nozzle. [Solving Means] In a nozzle mounting structure for mounting a nozzle 20 penetrating through a reactor vessel 10 having a hemispherical concave inner surface, the nozzle mounting structure includes a removed concave portion 17 in which a base material 12 on an inner surface side of the reactor vessel 10 is removed in a symmetrical shape around a normal line N on the hemispherical concave inner surface of the reactor vessel 10, a flange 25 provided on the nozzle 20, formed in a same symmetrical shape as that of the removed concave portion 17 around the normal line N, and inserted into the removed concave portion 17, and a weld part 18 provided around the normal line N for welding the flange 25 to the reactor vessel 10.

Abstract: A radiation shielding method and a device, and a method of processing a structure, in which a first radiation-shielded region (A1) is provided by disposing a first radiation-shielding device (100) outside a nuclear reactor vessel (41), a neutron flux detector (77) is moved into the radiation-shielded region (A1) through a conduit tube (65) by moving a thimble tube (68) from the nuclear reactor vessel (41), and an inspection/repair work of the nuclear reactor vessel (41) is then performed, so that an amount of radiation delivered to a worker can be easily and sufficiently reduced.

Abstract: To provide a nozzle welding method which can be performed automatically and efficiently, and which can also be performed under the condition of a high-exposure amount.