Patents by Inventor Noriyuki Kawahata

Noriyuki Kawahata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PREPARING PURIFIED POLYPEPTIDE COMPOSITIONS
    Publication number: 20240124518
    Abstract: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: June 2, 2023
    Publication date: April 18, 2024
    Inventors: Huw M. Nash, Matthew Iadanza, Christopher Leitheiser, Noriyuki Kawahata
  • METHODS FOR PREPARING PURIFIED POLYPEPTIDE COMPOSITIONS
    Publication number: 20220017569
    Abstract: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: July 23, 2021
    Publication date: January 20, 2022
    Inventors: Huw M. Nash, Matthew Iadanza, Christopher Leitheiser, Noriyuki Kawahata
  • Peptidomimetic macrocycles
    Patent number: 11008366
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: May 18, 2021
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Vincent Guerlavais, Noriyuki Kawahata
  • Peptidomimetic macrocycles
    Patent number: 10703780
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: July 7, 2020
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Vincent Guerlavais, Noriyuki Kawahata
  • Disubstituted amino acids and methods of preparation and use thereof
    Patent number: 10669230
    Abstract: Provided are crystalline ?, ?-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the ?, ?-disubstituted amino acids and their salts; methods of making these, and methods of using these.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: June 2, 2020
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Krzysztof Darlak, Noriyuki Kawahata, Sameer Ahmed Athamneh
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20200102351
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 6, 2019
    Publication date: April 2, 2020
    Inventors: Vincent GUERLAVAIS, Noriyuki KAWAHATA
  • PEPTIDOMIMETIC MACROCYCLES AND USE THEREOF IN REGULATING HIF1ALPHA
    Publication number: 20190225650
    Abstract: The present invention provides peptidomimetic macrocycles capable of regulating HIF1? and methods of using such macrocycles for the treatment of diseases.
    Type: Application
    Filed: January 30, 2019
    Publication date: July 25, 2019
    Inventors: Vincent GUERLAVAIS, Noriyuki KAWAHATA, Huw M. NASH, Carl ELKIN, Eric FEYFANT
  • Peptidomimetic macrocycles
    Patent number: 10308699
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: June 4, 2019
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Noriyuki Kawahata, Vincent Guerlavais, Manoj Samant
  • Peptidomimetic macrocycles
    Patent number: 10300109
    Abstract: Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an ?,?-disubstituted amino acid, or may comprise a crosslinker linking the ?-positions of at least two amino acids or at least one of said two amino acids may be an ?,?-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: May 28, 2019
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jia-Wen Han, Tomi K. Sawyer, Justin Noehre, Noriyuki Kawahata
  • Peptidomimetic macrocycles and use thereof in regulating HIF1alpha
    Patent number: 10246491
    Abstract: The present invention provides peptidomimetic macrocycles capable of regulating HIF1? and methods of using such macrocycles for the treatment of diseases.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: April 2, 2019
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Vincent Guerlavais, Noriyuki Kawahata, Huw M. Nash, Carl Elkin, Eric Feyfant
  • THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20190071469
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: June 29, 2018
    Publication date: March 7, 2019
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Jiawen Han
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20190062377
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 10, 2018
    Publication date: February 28, 2019
    Inventors: Vincent Guerlavais, Noriyuki Kawahata
  • DISUBSTITUTED AMINO ACIDS AND METHODS OF PREPARATION AND USE THEREOF
    Publication number: 20180265459
    Abstract: Provided are crystalline ?, ?-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the ?, ?-disubstituted amino acids and their salts; methods of making these, and methods of using these.
    Type: Application
    Filed: October 26, 2017
    Publication date: September 20, 2018
    Inventors: Krzysztof Darlak, Noriyuki Kawahata, Sameer Ahmed Athamneh
  • Peptidomimetic macrocycles
    Patent number: 9957299
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: May 1, 2018
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Vincent Guerlavais, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20180085426
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 21, 2017
    Publication date: March 29, 2018
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Jia-Wen HAN, Tomi K. SAWYER, Justin NOEHRE, Noriyuki KAWAHATA
  • Disubstituted amino acids and methods of preparation and use thereof
    Patent number: 9845287
    Abstract: Provided are crystalline ?, ?-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the ?, ?-disubstituted amino acids and their salts; methods of making these, and methods of using these.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: December 19, 2017
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Krzysztof Darlak, Noriyuki Kawahata, Sameer Ahmed Athamneh
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170298099
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: April 21, 2017
    Publication date: October 19, 2017
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Vincent GUERLAVAIS, Matthew IADANZA
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170299576
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: September 6, 2016
    Publication date: October 19, 2017
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170266254
    Abstract: Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an ?,?-disubstituted amino acid, or may comprise a crosslinker linking the ?-positions of at least two amino acids or at least one of said two amino acids may be an ?,?-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
    Type: Application
    Filed: November 11, 2016
    Publication date: September 21, 2017
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Jia-Wen HAN, Tomi K. SAWYER, Justin NOEHRE, Noriyuki KAWAHATA
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170226177
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: October 24, 2016
    Publication date: August 10, 2017
    Inventors: Noriyuki KAWAHATA, Vincent Guerlavais, Manoj Samant