Patents by Inventor Noriyuki Kawahata

Noriyuki Kawahata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES
    Publication number: 20170212125
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: August 10, 2016
    Publication date: July 27, 2017
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • Disubstituted amino acids and methods of preparation and use thereof
    Patent number: 9604919
    Abstract: Provided are crystalline ?, ?-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the ?, ?-disubstituted amino acids and their salts; methods of making these, and methods of using these.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: March 28, 2017
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Krzysztof Darlak, Noriyuki Kawahata, Sameer Ahmed Athamneh
  • DISUBSTITUTED AMINO ACIDS AND METHODS OF PREPARATION AND USE THEREOF
    Publication number: 20170066714
    Abstract: Provided are crystalline ?, ?-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the ?, ?-disubstituted amino acids and their salts; methods of making these, and methods of using these.
    Type: Application
    Filed: September 28, 2016
    Publication date: March 9, 2017
    Inventors: Krzysztof Darlak, Noriyuki Kawahata, Sameer Ahmed Athamneh
  • PEPTIDOMIMETIC MACROCYCLES WITH PTH ACTIVITY
    Publication number: 20170037086
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating parathyroid hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: April 9, 2015
    Publication date: February 9, 2017
    Inventors: Noriyuki Kawahata, Manoj Samant, Eric Feyfant
  • Peptidomimetic macrocycles
    Patent number: 9522947
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: December 20, 2016
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Noriyuki Kawahata, Vincent Guerlavais, Manoj Samant
  • Peptidomimetic macrocycles with improved properties
    Patent number: 9458202
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: October 4, 2016
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160257716
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: April 21, 2016
    Publication date: September 8, 2016
    Inventors: Vincent GUERLAVAIS, Noriyuki KAWAHATA
  • Methods for preparing purified polypeptide compositions
    Patent number: 9394336
    Abstract: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: July 19, 2016
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. Nash, Matthew Iadanza, Christopher Leitheiser, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160137710
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: June 25, 2015
    Publication date: May 19, 2016
    Inventors: Noriyuki Kawahata, Vincent Guerlavais, Manoj Samant
  • METHODS FOR PREPARING PURIFIED POLYPEPTIDE COMPOSITIONS
    Publication number: 20160115204
    Abstract: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: October 23, 2015
    Publication date: April 28, 2016
    Inventors: Huw M. Nash, Matthew Iadanza, Christopher Leitheiser, Noriyuki Kawahata
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160108089
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: May 21, 2015
    Publication date: April 21, 2016
    Inventors: Huw W. NASH, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Vincent GUERLAVAIS, Matthew IADANZA
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160096873
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: September 25, 2015
    Publication date: April 7, 2016
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES AND USE THEREOF IN REGULATING HIF1ALPHA
    Publication number: 20160052970
    Abstract: The present invention provides peptidomimetic macrocycles capable of regulating HIF1? and methods of using such macrocycles for the treatment of diseases.
    Type: Application
    Filed: September 2, 2015
    Publication date: February 25, 2016
    Inventors: Vincent GUERLAVAIS, Noriyuki KAWAHATA, Huw M. NASH, Carl ELKIN, Eric FEYFANT
  • Methods for preparing purified polypeptide compositions
    Patent number: 9206223
    Abstract: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: December 8, 2015
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. Nash, Matthew Iadanza, Christopher Leitheiser, Noriyuki Kawahata
  • Peptidomimetic macrocycles
    Patent number: 9175045
    Abstract: Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins; and methods of identifying and making such improved polypeptides.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: November 3, 2015
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosanna Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • Peptidomimetic macrocycles
    Patent number: 9096684
    Abstract: The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: August 4, 2015
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Noriyuki Kawahata, Vincent Guerlavais, Manoj Samant
  • THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20150038430
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: July 8, 2014
    Publication date: February 5, 2015
    Inventors: Huw M NASH, David Allen ANNIS, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Jiawen HAN
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20140378390
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: August 15, 2014
    Publication date: December 25, 2014
    Inventors: Vincent GUERLAVAIS, Noriyuki KAWAHATA
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20140323701
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: January 15, 2014
    Publication date: October 30, 2014
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, Rosanna Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Vincent Guerlavais, Matthew Iadanza
  • Peptidomimetic macrocycles
    Patent number: 8859723
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Grant
    Filed: August 13, 2011
    Date of Patent: October 14, 2014
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Vincent Guerlavais, Noriyuki Kawahata