Patents by Inventor Norman C. Nelson
Norman C. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140231710Abstract: The disclosure relates to formulations for use in deactivating nucleic acids and methods of making and using the same.Type: ApplicationFiled: April 24, 2014Publication date: August 21, 2014Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. NELSON, Kenneth A. BROWNE, Lizhong DAI, James RUSSELL, Mark E. FILIPOWSKY, Margarita B. KAMINSKY, Daniel L. KACIAN
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Patent number: 8784745Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte.Type: GrantFiled: June 24, 2013Date of Patent: July 22, 2014Assignee: Gen-Probe IncorporatedInventors: Norman C. Nelson, Gianluca Roma
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Patent number: 8765367Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: GrantFiled: December 12, 2008Date of Patent: July 1, 2014Assignees: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Patent number: 8765652Abstract: The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same.Type: GrantFiled: June 25, 2012Date of Patent: July 1, 2014Assignee: Gen-Probe IncorporatedInventors: Norman C. Nelson, Kenneth A. Browne, Lizhong Dai, James Russell, Mark E. Filipowsky, Margarita B. Kaminsky, Daniel L. Kacian
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Patent number: 8735055Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: GrantFiled: December 12, 2008Date of Patent: May 27, 2014Assignees: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Publication number: 20140127700Abstract: Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specifically to a target sequence that is amplified and a universal (U) sequence that is introduced into the sequence that is amplified, by using a primer for the universal sequence. Methods of nucleic acid amplification in vitro are disclosed that use one or more TSU oligonucleotides to attached a U sequence to a target nucleic acid in a target capture step and then use a primer for a U sequence in subsequent amplification steps performed in substantially isothermal conditions to make amplification products that contain a U sequence that indicates the presence of the target nucleic acid in a sample.Type: ApplicationFiled: December 17, 2013Publication date: May 8, 2014Applicant: GEN-PROBE INCORPORATEDInventors: Steven T. BRENTANO, Dmitry LYAKHOV, James D. CARLSON, Norman C. NELSON, Lyle J. ARNOLD, JR., Michael M. BECKER
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Publication number: 20140080728Abstract: Methods for selecting tag-oligonucleotide sequences for use in an in vitro nucleic acid assay. The selected tag sequences are useful for nucleic acid assay wherein interference between the nucleic acid sequences is the assay is to be controlled. Selected tag sequences are incorporated into nucleic acid assay to improve the performance of and/or minimize any interference between nucleic acids in the assay compared to untagged assays.Type: ApplicationFiled: March 12, 2012Publication date: March 20, 2014Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. Nelson, Jijumon Chelliserry
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Publication number: 20140066326Abstract: Improved methods for use in nucleic acid amplification, including multiplex amplification, where the amplification is carried out in two or more distinct phases are disclosed. The first phase amplification reaction preferably lacks one or more components required for exponential amplification. The lacking component is subsequently provided in a second, third or further phase(s) of amplification, resulting in a rapid exponential amplification reaction. The multiphase protocol results in faster and more sensitive detection and lower variability at low analyte concentrations. Compositions for carrying out the claimed methods are also disclosed.Type: ApplicationFiled: August 30, 2013Publication date: March 6, 2014Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. NELSON, Lyle J. ARNOLD, JR., Lizhong DAI, Steven PHELPS, Jijumon CHELLISERRY
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Patent number: 8642268Abstract: Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specifically to a target sequence that is amplified and a universal (U) sequence that is introduced into the sequence that is amplified, by using a primer for the universal sequence. Methods of nucleic acid amplification in vitro are disclosed that use one or more TSU oligonucleotides to attached a U sequence to a target nucleic acid in a target capture step and then use a primer for a U sequence in subsequent amplification steps performed in substantially isothermal conditions to make amplification products that contain a U sequence that indicates the presence of the target nucleic acid in a sample.Type: GrantFiled: April 30, 2012Date of Patent: February 4, 2014Assignee: Gen-Probe IncorporatedInventors: Steven T. Brentano, Dmitry Lyakhov, James D. Carlson, Norman C. Nelson, Lyle J. Arnold, Jr., Michael M. Becker
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Publication number: 20140004517Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte.Type: ApplicationFiled: June 24, 2013Publication date: January 2, 2014Inventors: Norman C. Nelson, Gianluca ROMA
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Publication number: 20130309673Abstract: Compositions, reaction mixtures, and methods for performing an amplification reaction, including multiplex amplification reaction, wherein the method comprises using one or more amplification oligomer complexes comprising linked first and second amplification oligomer members. In one aspect, the amplification oligomer complex is hybridized to a target nucleic acid, the target nucleic acid with hybridized amplification oligomer complex is then captured, and other components are washed away. Target sequences of the target nucleic acids are pre-amplified to generate a first amplification product. The first amplification product is amplified in one or more secondary amplification reactions to generate second amplification products.Type: ApplicationFiled: July 31, 2013Publication date: November 21, 2013Applicant: Gen-Probe IncorporatedInventors: Steven T. BRENTANO, Dmitry LYAKHOV, Norman C. NELSON, James D. CARLSON, Michael M. BECKER, Lyle J. ARNOLD, JR.
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Patent number: 8512955Abstract: Compositions, reaction mixtures, and methods for performing an amplification reaction, including multiplex amplification reaction, wherein the method comprises using one or more amplification oligomer complexes comprising linked first and second amplification oligomer members. In one aspect, the amplification oligomer complex is hybridized to a target nucleic acid, the target nucleic acid with hybridized amplification oligomer complex is then captured, and other components are washed away. Target sequences of the target nucleic acids are pre-amplified to generate a first amplification product. The first amplification product is amplified in one or more secondary amplification reactions to generate second amplification products.Type: GrantFiled: July 1, 2010Date of Patent: August 20, 2013Assignee: Gen-Probe IncorporatedInventors: Steven T. Brentano, Dmitry Lyakhov, Norman C. Nelson, James D. Carlson, Michael M. Becker, Lyle J. Arnold, Jr.
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Patent number: 8491178Abstract: A receptacle having interconnected chambers arranged to permit multiple process steps to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.Type: GrantFiled: March 7, 2012Date of Patent: July 23, 2013Assignees: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Patent number: 8480976Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: GrantFiled: July 13, 2011Date of Patent: July 9, 2013Assignees: Gen-Probe Incorporated, Qualigen, Inc.Inventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Patent number: 8368882Abstract: A signal detection system configured for detecting a signal emitted by the contents of a reaction receptacle is also configured to apply thermal energy to a portion of the reaction receptacle to affect a reaction occurring within the reaction receptacle. More particularly, a system for detecting electromagnetic radiation emitted by the contents of a reaction receptacle includes a transmission element configured for transmitting electromagnetic radiation from the contents of the receptacle, a thermal element associated with the transmission element and configured to apply thermal energy to at least a portion of the receptacle, and a detector configured to receive electromagnetic radiation from the transmission element and to generate a signal corresponding to a characteristic of the electromagnetic radiation received by the detector.Type: GrantFiled: January 29, 2010Date of Patent: February 5, 2013Assignee: Gen-Probe IncorporatedInventors: David Opalsky, George T. Walker, Norman C. Nelson, Richard S. Lee, Sara H. Fan
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Publication number: 20120264122Abstract: Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specifically to a target sequence that is amplified and a universal (U) sequence that is introduced into the sequence that is amplified, by using a primer for the universal sequence. Methods of nucleic acid amplification in vitro are disclosed that use one or more TSU oligonucleotides to attached a U sequence to a target nucleic acid in a target capture step and then use a primer for a U sequence in subsequent amplification steps performed in substantially isothermal conditions to make amplification products that contain a U sequence that indicates the presence of the target nucleic acid in a sample.Type: ApplicationFiled: April 30, 2012Publication date: October 18, 2012Applicant: GEN-PROBE INCORPORATEDInventors: Steven T. BRENTANO, Dmitry LYAKHOV, James D. CARLSON, Norman C. NELSON, Lyle J. ARNOLD, JR.
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Publication number: 20120260951Abstract: The present invention relates to reagents for use in deactivating nucleic acids and methods of making and using the same.Type: ApplicationFiled: June 25, 2012Publication date: October 18, 2012Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. NELSON, Kenneth A. BROWNE, Lizhong DAI, James RUSSELL, Mark E. FILIPOWSKY, Margarita B. KAMINSKY, Daniel L. KACIAN
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Publication number: 20120250452Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: ApplicationFiled: September 23, 2011Publication date: October 4, 2012Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. NELSON, Gianluca ROMA
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Publication number: 20120231456Abstract: A receptacle having interconnected chambers arranged to permit multiple process steps to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.Type: ApplicationFiled: March 7, 2012Publication date: September 13, 2012Applicants: QUALIGEN, INC., GEN-PROBE INCORPORATEDInventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor
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Publication number: 20120211088Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.Type: ApplicationFiled: August 22, 2011Publication date: August 23, 2012Applicant: GEN-PROBE INCORPORATEDInventors: Norman C. Nelson, Gianluca Roma