Patents by Inventor Noubar B. Afeyan

Noubar B. Afeyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNERGISTIC BACTERIAL COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20140199281
    Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Application
    Filed: March 20, 2014
    Publication date: July 17, 2014
    Applicant: Seres Health, Inc.
    Inventors: Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David A. Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • SYNERGISTIC BACTERIAL COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20140147425
    Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Application
    Filed: November 26, 2013
    Publication date: May 29, 2014
    Applicant: Seres Health, Inc.
    Inventors: Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David A. Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • TERMINALLY MODIFIED RNA
    Publication number: 20140147454
    Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
    Type: Application
    Filed: October 2, 2013
    Publication date: May 29, 2014
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Tirtha Chakraborty, Stephane Bancel, Stephen G. Hoge, Atanu Roy, Antonin de Fougerolles, Noubar B. Afeyan
  • Engineered nucleic acids encoding a modified erythropoietin and their expression
    Patent number: 8710200
    Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: April 29, 2014
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Jason P. Schrum, Noubar B. Afeyan, Gregory J. Sieczkiewicz, Stephane Bancel, Antonin de Fougerolles, Sayda M. Elbashir
  • MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
    Publication number: 20130266640
    Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
    Type: Application
    Filed: June 14, 2013
    Publication date: October 10, 2013
    Inventors: Antonin de Fougerolles, Kristy M. Wood, Sayda M. Elbashir, Noubar B. Afeyan, Pedro Valencia, Jason P. Schrum
  • DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS
    Publication number: 20120251618
    Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
    Type: Application
    Filed: April 2, 2012
    Publication date: October 4, 2012
    Applicant: modeRNA Therapeutics
    Inventors: Jason P. Schrum, Noubar B. Afeyan, Gregory J. Sieczkiewicz, Stephane Bancel, Antonin de Fougerolles, Sayda M. Elbashir
  • Proteome epitope tags and methods of use thereof in protein modification analysis
    Patent number: 8244484
    Abstract: Disclosed are methods for reliably detecting the presence of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a protein or a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: August 14, 2012
    Assignee: EMD Millipore Corporation
    Inventors: Frank D. Lee, Xun Meng, Noubar B. Afeyan
  • Engineered CO2 fixing microorganisms producing carbon-based products of interest
    Patent number: 8227237
    Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: July 24, 2012
    Assignee: Joule Unlimited Technologies, Inc.
    Inventors: Nikos B. Reppas, Martha Sholl, Sriram Kosuri, Brian D. Green, Christian P. Ridley, Frank A. Skraly, Dan E. Robertson, David A. Berry, Noubar B. Afeyan
  • ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST
    Publication number: 20120122193
    Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
    Type: Application
    Filed: January 12, 2012
    Publication date: May 17, 2012
    Applicant: JOULE UNLIMITED TECHNOLOGIES, INC.
    Inventors: David A. Berry, Dan E. Robertson, Frank A. Skraly, Brian D. Green, Christian P. Ridley, Sriram Kosuri, Nikos B. Reppas, Martha Sholl, Noubar B. Afeyan
  • ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
    Publication number: 20120065252
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
    Type: Application
    Filed: August 5, 2011
    Publication date: March 15, 2012
    Inventors: Jason Schrum, Stéphane Bancel, Noubar B. Afeyan
  • Method and system for profiling biological systems
    Patent number: 8068987
    Abstract: The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: November 29, 2011
    Assignee: BG Medicine, Inc.
    Inventors: Noubar B. Afeyan, Jan van der Greef, Frederick E. Regnier, Aram S. Adourian, Eric K. Neumann, Matej Oresic, Elwin Robbert Verheij
  • ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST
    Publication number: 20110262975
    Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 27, 2011
    Applicant: c/o JOULE UNLIMITED, INC.
    Inventors: David A. Berry, Dan E. Robertson, Frank A. Skraly, Brian D. Green, Christian P. Ridley, Sriram Kosuri, Nikos B. Reppas, Martha Sholl, Noubar B. Afeyan
  • Engineered CO2 fixing microorganisms producing carbon-based products of interest
    Patent number: 7981647
    Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: July 19, 2011
    Assignee: Joule Unlimited, Inc.
    Inventors: David A. Berry, Dan E. Robertson, Frank A. Skraly, Brian D. Green, Christian P. Ridley, Sriram Kosuri, Nikos B. Reppas, Martha Sholl, Noubar B. Afeyan
  • METHODS AND COMPOSITIONS FOR REDUCING STEMNESS IN ONCOGENESIS
    Publication number: 20110044895
    Abstract: The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The cancer stem cells, if present, can be more resistant to traditional drug-based therapies and can provide a source for new, differentiated cancer cells associated with the development of drug-resistance and more aggressive phenotypes. When combined with traditional cancer therapies, for example, drug-based therapies, the methods and compositions of the invention provide a more effective way for treating cancer and can provide a model system for developing new cancer therapies and new treatment modalities.
    Type: Application
    Filed: August 9, 2010
    Publication date: February 24, 2011
    Inventors: David A. Berry, Eric J. Devroe, Noubar B. Afeyan, Brett Chevalier, Sashank K. Reddy
  • Engineered CO2 Fixing Microorganisms Producing Carbon-Based Products of Interest
    Publication number: 20110008861
    Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
    Type: Application
    Filed: March 3, 2009
    Publication date: January 13, 2011
    Applicant: Joule Unlimited, Inc.
    Inventors: David A. Berry, Dan E. Robertson, Frank A. Skraly, Brian D. Green, Christian P. Ridley, Sriram Kosuri, Nikos B. Reppas, Martha Sholl, Noubar B. Afeyan
  • Proteome Epitope Tags and Methods of Use Thereof in Protein Modification Analysis
    Publication number: 20100184613
    Abstract: Disclosed are methods for reliably detecting the presence of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a protein or a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
    Type: Application
    Filed: October 9, 2009
    Publication date: July 22, 2010
    Applicant: Millipore Corporation
    Inventors: Frank D. Lee, Xun Meng, Noubar B. Afeyan
  • Method for iterative design of products
    Patent number: 7730002
    Abstract: The invention involves generating and presenting, typically electronically, a number of design alternatives to persons who are participating in the design, selection, or market research exercise. The participants (referred to as “selectors”) transmit data indicative of their preferences among or between the presented design alternatives, and that data is used to derive a new generation of design alternatives or proposals. The new designs are generated through the use of a computer program exploiting a genetic or evolutionary computational technique. The process is repeated, typically for many iterations or cycles.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: June 1, 2010
    Inventors: Noubar B. Afeyan, Kamal M. Malek, Nigel J. Bufton, Sevan G. Ficici, Howard A. Austin, Larry J. Austin, legal representative, Honor E. McClellan, legal representative
  • Proteome epitope tags and methods of use thereof in protein modification analysis
    Patent number: 7618788
    Abstract: Disclosed are methods for reliably detecting the presence of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a protein or a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: November 17, 2009
    Assignee: Millipore Corporation
    Inventors: Frank D. Lee, Xun Meng, Noubar B. Afeyan
  • Method and apparatus for evolutionary design
    Patent number: 7610249
    Abstract: The invention involves generating and presenting, typically electronically, a number of design alternatives to persons who are participating in the design, selection, or market research exercise. The participants (referred to as “selectors”) transmit data indicative of their preferences among or between the presented design alternatives, and that data is used to derive a new generation of design alternatives or proposals. The new designs are generated through the use of a computer program exploiting a genetic or evolutionary computational technique. The process is repeated, typically for many iterations or cycles.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: October 27, 2009
    Assignee: Affinova, Inc.
    Inventors: Noubar B. Afeyan, Kamal M. Malek, Nigel J. Bufton, Sevan G. Ficici, Howard A. Austin, Larry J. Austin, legal representative, Honor E. McClellan, legal representative
  • Method and apparatus for dynamic, real-time market segmentation
    Patent number: 7177851
    Abstract: The invention involves generating and presenting, typically electronically, a number of design alternatives to persons who are participating in the design, selection, or market research exercise. The participants (referred to as “selectors”) transmit data indicative of their preferences among or between the presented design alternatives, and that data is used to derive a new generation of design alternatives or proposals. The new designs are generated through the use of a computer program exploiting a genetic or evolutionary computational technique. The process is repeated, typically for many iterations or cycles.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: February 13, 2007
    Assignee: Affinnova, Inc.
    Inventors: Noubar B. Afeyan, Kamal M. Malek, Nigel J. Bufton, Sevan G. Ficici, Larry J. Austin, legal representative, Honor E. McClellan, legal representative, Howard A. Austin, deceased