Patents by Inventor Ole Nielsen
Ole Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110046218Abstract: The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.Type: ApplicationFiled: November 1, 2010Publication date: February 24, 2011Applicant: H. LUNDBECK A/SInventors: Robert Dancer, Hans Petersen, Ole Nielsen, Michael Harold Rock, Helle Eliasen, Ken Liljegren
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Publication number: 20100324291Abstract: Methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and salts thereof are described.Type: ApplicationFiled: June 22, 2010Publication date: December 23, 2010Applicant: H. LUNDBECK A/SInventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngsø, Sherry Lynn Collier
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Patent number: 7834201Abstract: The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.Type: GrantFiled: June 21, 2006Date of Patent: November 16, 2010Assignee: H. Lundbeck A/SInventors: Robert Dancer, Hans Petersen, Ole Nielsen, Michael Harold Rock, Helle Eliasen, Ken Liljegren
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Patent number: 7789866Abstract: An ostomy bag with a filter assembly having a gas filter and a pre-filter for preventing or delaying solid/semisolid matter and liquid from reaching the gas filter. The pre-filter is at least substantially flat and comprises a number of constrictions, such as ribs extending along and between two inner surface parts of the channel. These constrictions/ribs form narrower and wider passages where the gas may more quickly pass a narrow passage and where the wider passages tend to receive and hold the liquid, solid matter and semisolid matter. The constrictions may be provided as a single, monolithic element, such as an extruded element.Type: GrantFiled: December 23, 2004Date of Patent: September 7, 2010Assignee: Coloplast A/SInventors: Lars Bo Poulsen, Bjarne Worsoe, Morgens Kristensen, Per Ole Nielsen, Hans Olsen
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Patent number: 7767683Abstract: 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate, pharmaceutical compositions containing the salt and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and medical uses thereof.Type: GrantFiled: August 18, 2004Date of Patent: August 3, 2010Assignee: H. Lundbeck A/SInventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngso, Sherry Lynn Collier
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Patent number: 7723533Abstract: The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.Type: GrantFiled: March 12, 2008Date of Patent: May 25, 2010Assignee: H. Lundbeck A/SInventors: Robert Dancer, Hans Petersen, Ole Nielsen, Michael Harold Rock, Helle Eliasen, Ken Liljegren
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Patent number: 7560576Abstract: The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.Type: GrantFiled: March 12, 2008Date of Patent: July 14, 2009Assignee: H. Lundbeck A/SInventors: Robert Dancer, Hans Petersen, Ole Nielsen, Michael Harold Rock, Helle Eliasen, Ken Liljegren
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Publication number: 20080269248Abstract: A tartrate and malate salt of trans-1-(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine, in particular for medical use, pharmaceutical formulations thereof, including for treatment of schizophrenia or other diseases involving psychotic symptoms.Type: ApplicationFiled: February 14, 2006Publication date: October 30, 2008Applicant: H. Lundbeck A/SInventors: Ole Nielsen, Heidi Lopez de Diego, Benny Bang-Andersen
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Patent number: 7399987Abstract: A planar electron emitter, based on the existence of quasi-ballistic transport of electrons is disclosed.Type: GrantFiled: June 11, 1999Date of Patent: July 15, 2008Inventors: Petr Viscor, Niels Ole Nielsen, Armin Delong, Vladimir Kolarik
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Publication number: 20080161584Abstract: The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.Type: ApplicationFiled: March 12, 2008Publication date: July 3, 2008Applicant: H. LUNDBECK A/SInventors: Robert Dancer, Hans Petersen, Ole Nielsen, Michael Harold Rock, Helle Eliasen, Ken Liljegren
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Publication number: 20080161388Abstract: The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.Type: ApplicationFiled: March 12, 2008Publication date: July 3, 2008Applicant: H. LUNDBECK A/SInventors: Robert Dancer, Hans Petersen, Ole Nielsen, Michael Harold Rock, Helle Eliasen, Ken Liljegren
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Patent number: 7367965Abstract: An ostomy appliance with a front wall and a rear wall of flexible material forming a bag, the rear wall having an opening into the bag by which waste material can enter the bag. The bag has two or more vents through which gas may escape from the bag and a filter device covering each vent. Each filter device has gas inlet and outlet openings in communication with a respective filter body so that in use gas flows through the filter device from the inlet opening through the filter body to the outlet opening. The inlet openings communicate with the inner space of the bag and are located near the border of the bag, being spaced at an angle of at least 45 degrees along radii of a circle of reference having a perimeter concentric with the waste opening of the bag.Type: GrantFiled: February 26, 2003Date of Patent: May 6, 2008Assignee: Coloplast A/SInventors: Lars Bo Poulsen, Per Ole Nielsen
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Patent number: 7298487Abstract: A method and apparatus for measuring light reflections of an object, comprising a light-source illumination-observation assembly, the assembly comprising: (A) an illumination unit comprising an illumination light source and illumination aperture stop being arranged to provide a confined luminous field, an illumination field stop (307) adapted to provide an illumination beam (305) of light from said confined luminous field, an collimating optical element (309) adapted to collimate said illumination beam and to provide an illumination field (313) on an object; (B) an observation unit comprising: at least one observation field stop adapted to provide an observation beam (306) comprising a ray boundary, at least one focusing optical element (309) adapted to focus said observation beam, an observation light receiver; and (C) at least one common optical element (309) arranged so that said illumination beam and said observation beam form an overlap therein; and (D) a unit separation stop (310) adapted to stop lightType: GrantFiled: April 2, 2003Date of Patent: November 20, 2007Assignee: Delta Dansk Elektronik, Lys & AkustikInventors: Jan Harries Hansen, Hans Ole Nielsen, Kai Ove Sørensen, Jesper Falden Offersgaard
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Patent number: 7289204Abstract: An apparatus and devices for measuring fluorescence lifetimes of fluorescence sensors for one or more analytes, the apparatus comprising (c) one or more reference systems (3,6,7), said reference systems each comprising one or more reference light sources (3) and being adapted to receive one or more excitation signals (1a), to produce reference optical signals (6b) in response thereto, and to produce one or more electrical reference output signals (7b) in response to one or more excitation signals (1a); and (d) or more phase detectors (10), said phase detections being adapted to detect one or more delays of said one or more electrical output signals of said one or more fluorescence sensor systems and said one or more reference systems, and to produce one or more phase output signals; and a method of measuring concentration of one or more analytes using such apparatus and/or devices.Type: GrantFiled: May 2, 2002Date of Patent: October 30, 2007Assignee: Delta Dansk Elektronik, Lys & AkustikInventors: Hans Ole Nielsen, Jan H. Hansen, Kim P. Hansen
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Publication number: 20070191339Abstract: Described are crystalline forms of the pharmaceutical compound “[9S-(9?,10?,12?)]-5,16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9, 12-epoxy-1H-diindolo[1,2,3-fg:3?,2?,1?-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester”, as well as methods for their use and preparation.Type: ApplicationFiled: February 24, 2005Publication date: August 16, 2007Applicant: H. Lundbeck A/SInventors: Michael Rock, Heidi Lopez De Diego, Kim Christensen, Ole Nielsen, Anders Buur, Mark Howells
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Publication number: 20070138173Abstract: A storage container is provided, having a first container portion and a second container portion. The first container portion is approximately 24 feet in length, having a first front portion. The second container portion is approximately 16 feet in length, having a second front portion. The first and second front portions are coupled to form a storage container approximately 40 feet in length and having a opening extending approximately 40 feet through the storage container. A first panel of the first front portion is mounted to an inside surface of the storage container and a second panel of the second front portion is mounted to an inside surface of the storage container.Type: ApplicationFiled: June 30, 2006Publication date: June 21, 2007Applicant: Flex Box Ltd.Inventor: Ole Nielsen
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Publication number: 20070112301Abstract: The invention provides an actuator system comprising an actuator member having first and second positions. The system further comprises actuating means for moving the actuator member between the first and second positions and detection means for detecting the first respectively the second position and supplying time signals indicative thereof. A controller determines on the basis of supplied time signals the time lapsed when the actuator member is moved between the first and second positions in a given direction, the controller comprising information representing at least one defined time range, each time range being associated with movement of the actuator member in a given direction between the first and second positions and a given actuation force, the controller being adapted to compare the determined time lapsed with the defined time range(s) and perform an action corresponding to the time range associated with the determined time lapsed.Type: ApplicationFiled: September 29, 2006Publication date: May 17, 2007Applicant: Novo Nordisk A/SInventors: Jan Preuthun, Ole Nielsen, Steffen Hansen, Bjorn Larsen, Henrik Bengtsson
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Publication number: 20070104596Abstract: The invention provides a pump assembly comprising an actuator lever, a supporting structure, a pump comprising a pump member moveable by actuation of the actuator lever, and an actuator for moving the actuator lever. A first stationary pivoting joint is formed between the actuator lever and the supporting structure, and a second floating pivoting joint is formed between the actuator lever and the pump member allowing the pump member to float relative to the actuator lever, the floating pivoting point providing a constant-length actuator arm defined between the first pivoting joint and the second pivoting joint.Type: ApplicationFiled: September 29, 2006Publication date: May 10, 2007Applicant: Novo Nordisk A/SInventors: Jan Preuthun, Ole Nielsen, Steffen Hansen, Bjorn Larsen, Henrik Bengtsson, Leif Johannsen, Finn Jensen
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Publication number: 20070021733Abstract: A medical device is provided comprising a reservoir adapted to contain a fluid drug in an interior thereof, and a pump assembly. The pump assembly comprises a pump inlet, a pump outlet and an internal flow path arranged there between, and a fluid connector having an inlet and an outlet. The fluid connector is arranged to be operated from an initial state in which the fluid connector is arranged within the interior of the pump and an actuated state in which fluid communication is established between the interior of the reservoir and the interior of the pump assembly via the fluid connector and with the outlet of the fluid connector being arranged in the flow path of the pump assembly.Type: ApplicationFiled: April 20, 2006Publication date: January 25, 2007Applicant: Novo Nordisk A/SInventors: Steffen Hansen, Bjorn Larsen, Claus Moller, Ole Nielsen, Jim Radmer, Jan Preuthun, Philip Sparholt, Erik Ethelfeld
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Publication number: 20070021499Abstract: The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.Type: ApplicationFiled: June 21, 2006Publication date: January 25, 2007Applicant: H. Lundbeck A/SInventors: Robert Dancer, Hans Petersen, Ole Nielsen, Michael Rock, Helle Eliasen, Ken Liljegren