Abstract: 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate or hydrogen malonate, pharmaceutical compositions containing these salts and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and medical uses thereof.

Abstract: A medical device is provided comprising a transcutaneous device unit and a reservoir unit. The transcutaneous device unit comprises a transcutaneous device for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The reservoir unit comprises a reservoir adapted to contain a fluid drug, the reservoir comprising an outlet means allowing the transcutaneous device to be arranged in fluid communication with an interior of the reservoir, and an expelling assembly for expelling a fluid drug out of the reservoir and through the skin of the subject via the transcutaneous device. The transcutaneous device unit and the reservoir unit further comprise coupling means allowing the reservoir unit to be secured to the transcutaneous device unit in the situation of use. By this arrangement a two-unit system is provided which can be used in a convenient and cost-effective manner.

Abstract: A pulse width modulator (10) for converting a digital signal into a PWM signal, comprising a plurality of integrators (11) with integrator gains (12) arranged in series, a comparator (17) for comparing the output of the last integrator (11?) with a reference, and thereby creating the PWM signal. The modulator further has means (13) for realizing self-oscillation at a desired switching frequency, and a feedback path (14) connected to a point down stream said comparator and leading to a plurality of summing points, each preceding one of said integrators, wherein the PWM signal is quantized in time by the clock frequency of the modulator, and wherein the integrator gains (12) are adapted to reduce any quantization noise.

Abstract: The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and/or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-citalopram with more than 50% of one of the enantiomers into a fraction consisting of racemic citalopram and/or a fraction of S-citalopram or R-citalopram characterized in that i) citalopram is precipitated from a solvent as the free base or as an acid addition salt thereof; ii) the precipitate formed is separated from the mother liquor; iia) if the precipitate is crystalline it is optionally recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iib) if the precipitate is not crystalline, steps i) and ii) are optionally repeated until a crystalline precipitate is obtained and the crystalline precipitate is recrystallised one or more times to form racemic citalopram, and then optionally converted into an aci

Abstract: The present invention relates to a hydrohalogenide of 1?-[4-[1-(4-fluorophenyl)-1H-indole-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4?-piperidine], pharmaceutical compositions containing the acid addition salts and the use thereof for the treatment of psychic and neurological disorders.

Abstract: A half-bridge driver includes first and second power switches, connected with their respective current paths in series, a pulse generator for generating a voltage pulse waveform, arranged to drive the first power switch, a first current generator for generating a current pulse for each negative flank of the voltage pulse waveform, a second current generator for generating a current pulse for each positive flank of said voltage pulse waveform, and a differential current receiver circuit. The differential current receiver circuit is connected to the first and second current generators, and is arranged to generate an output signal equal to the difference of the currents flowing through the current generators. The output signal is arranged to drive the second power switch.

Abstract: A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.

Abstract: A solid unit dosage form comprising citalopram, which is prepared by direct compression of a mixture of citalopram base or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable excipients, or by filling of said mixture in a hard gelatine capsule. Large crystals of a pharmaceutical acceptable salt of citalopram and method for the manufacture of said large crystals.

Abstract: A solid unit dosage form comprising citalopram, which is prepared by direct compression of a mixture of citalopram base or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable excipients, or by filling of said mixture in a hard gelatine capsule. Large crystals of a pharmaceutical acceptable salt of citalopram and method for the manufacture of said large crystals.

Abstract: The present invention relates to a hydrohalogenide of 1?-[4-[1-(4-fluorophenyl)-1H-indole-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4?-piperidine], pharmaceutical compositions containing the acid addition salts and the use thereof for the treatment of psychic and neurological disorders.

Abstract: The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and/or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-citalopram with more than 50% of one of the enantiomers into a fraction consisting of racemic citalopram and/or a fraction of S-citalopram or R-citalopram characterized in that i) citalopram is precipitated from a solvent as the free base or as an acid addition salt thereof; ii) the precipitate formed is separated from the mother liquor; iia) if the precipitate is crystalline it is optionally recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iib) if the precipitate is not crystalline, steps i) and ii) are optionally repeated until a crystalline precipitate is obtained and the crystalline precipitate is recrystallised one or more times to form racemic citalopram, and then optionally converted into an aci

Abstract: An apparatus and devices for measuring fluorescence lifetimes of fluorescence sensors for one or more analytes, the apparatus comprising (c) one or more reference systems (3,6,7), said reference systems each comprising one or more reference light sources (3) and being adapted to receive one or more excitation signals (1a), to produce reference optical signals (6b) in response thereto, and to produce one or more electrical reference output signals (7b) in response to one or more excitation signals (1a); and (d) or more phase detectors (10), said phase detections being adapted to detect one or more delays of said one or more electrical output signals of said one or more fluorescence sensor systems and said one or more reference systems, and to produce one or more phase output signals; and a method of measuring concentration of one or more analytes using such apparatus and/or devices.

Abstract: In an ostomy appliance comprising an adhesive, flexible, skin barrier product for securing the appliance to the user's skin, said skin barrier having a hole for receiving a stoma, ureter or catheter, and said skin barrier comprising, in the surface to be secured to the user's skin, at least a first zone showing adhesive and barrier properties and a second zone showing moisture absorbing properties wherein the first zone comprises a substantially homogeneous mixture of from 15 to 95% by weight of one or more rubbery components and from 2 to 85% by weight of a starch, and furthermore may comprise from 0 to 60% by weight of one or more hydrocolloids, from 0 to 50% by weight of one or more tackifier resins, from 0 to 10% by weight of one or more plasticizers and from 0 to 5% by weight of a pigment, the barrier adhesive “behaves”, in a dry state, Theologically as an adhesive comprising hydrocolloid but which does not absorb moisture in the presence of moisture.

Abstract: The invention is directed to methods of crystallizing pharmaceutically acceptable salts of citalopram, the resulting crystals, and pharmaceutical compositions comprising the crystals.

Abstract: A solid unit dosage form comprising citalopram, which is prepared by direct compression of a mixture of citalopram base or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable excipients, or by filling of said mixture in a hard gelatine capsule. Large crystals of a pharmaceutical acceptable salt of citalopram and method for the manufacture of said large crystals.

Abstract: The present invention relates to a hydrohalogenide of 1′-[4-[1-(4-fluorophenyl)-1H-indole-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4′-piperidine], pharmaceutical compositions containing the acid addition salts and the use thereof for the treatment of psychic and neurological disorders.

Abstract: A carriage body for a vehicle is described. It is possible to perform a displacement of a frame element (8) with respect to the outlook through windows (5) from each seat (14) in a train coach. Thus, the frame elements (8) are fastened to the cover plates (3, 4) of the coach above and below the window (5) via grooves (11) in which there are provided connecting means (13) sliding in the grooves (11). Hereby the frame elements (8) may be displaced longitudinally relative to the coach.

Abstract: In addition to a sewing machine, a sewing unit has a workpiece holder, which has two workpiece bearing plates displaceable relative to each other, a holding bar, a folding, bar, a thrower device, a cloth slider and a folding device. By these devices, first and second trouser parts having rim strips are faced and overlapped inside-out onto a zipper. The front inseam is sewn, then the rim strip of the second trouser part is folded over and a first zipper seam is sewn. The second trouser part is folded over right-side out and the j-seam is sewn. The rim strips of the first and second trouser parts can be folded before sewing, seam locks can be provided, and a lower covering strip can be provided to the zipper as well. Thus, all three seams can be sewn with a single sewing arrangement.

Abstract: A block-shaped measuring chamber unit, especially for use in electrochemical measuring apparatuses for defining measuring chambers therein. The block-shaped unit has oppositely directed or otherwise differently orientated surface parts each defining a depression to be used as a measuring chamber. These depressions are interconnected by means of straight bores or passages extending through the block-shaped unit. The block-shaped unit is preferably made from machinable glass-ceramic.