Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Abstract: A surface cleaning head may include a fluid distributor configured to distribute a cleaning fluid, an agitator configured to absorb at least a portion of the distributed cleaning fluid and to agitate debris on the surface to be cleaned, a fluid stripper configured to remove, from the agitator, at least a portion of the distributed cleaning fluid absorbed by the agitator, a debris container, and a removable cover. The debris container may include a solid debris chamber and a fluid debris chamber. The removable cover may include a fluid catch plate configured to transfer at least a portion of the cleaning fluid removed from the agitator by the fluid stripper to the fluid debris chamber, the fluid catch plate being configured to selectively transition between an in-use position and a cleaning position when the removable cover is removed from the surface cleaning head.

Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Abstract: Secure sharing of a document on a co-browse session is implemented by causing a JavaScript implemented document viewer to create HTML5 description of a rendered view of a document's content, and transmitting the HTML5 description of the rendered view of the document content as a DOM elements on the co-browse session. The rendered view of the document is overlayed on the web page being co-browsed, which enables the participants to the co-browse session to collaboratively view the rendered view of the document. However, since the document itself only resides in the visitor's browser, the document itself is not transmitted on the co-browse session. Media URLs can also be shared, and the participants' views of the audio/video media is synchronized by causing the video to play locally at each participant but synchronized with the visitor. Live video of the participants to the co-browse session is also implemented.

Abstract: An apparatus for recovering heat in an ablutionary or plumbing system includes first and second pipes for carrying fluids at different temperatures. A first heat transfer element is configured to be thermally coupled to the first pipe and a second heat transfer element configured to be thermally coupled to the second pipe, with each having an elongate portion extending in a direction away from the associated pipe. The elongate portions of the first and second heat transfer elements at least partially overlap. A thermoelectric device is provided that includes one or more thermoelectric elements located between the elongate portions, the thermoelectric element(s) being in thermal communication with the elongate portion of the first heat transfer element and the elongate portion of the second heat transfer element and being arranged to generate electricity from a temperature differential between the elongate portions of the first and second heat transfer elements.

Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Abstract: The heat exchanger tray provided herein may include a base, a cover, and a heat exchange coil. The base may include a cutout and a bottom portion with one or more sidewalls forming a serpentine path for wastewater. The cover may be positioned within the cutout of the base to create a space between the base and the cover. The cover may include one or more protruding portions that engage with the one or more sidewalls of the bottom portion of the base to enclose the serpentine path. The heat exchange coil may be positioned in and along at least a portion of the serpentine path between the base and the cover. Fresh water may flow through the heat exchange coil. Wastewater may flow through the serpentine path between the base and the cover, such that the wastewater may heat the fresh water flowing through the heat exchange coil.

Abstract: A fluid flow control valve assembly is provided, and includes a fluid flow control valve which includes a first flow control member having one or more flow channels, and a second flow control member adjacent to the first flow control member. The second flow control member moves relative to the first flow control member. A first valve actuator causes movement of the second flow control member relative to the first flow control member. An operating member connects to the first valve actuator. The operating member moves in a linear direction and the operating member on the first valve actuator moves the second flow control member. Movement of the second flow control member adjusts the position of the second flow control member relative to the one or more flow channels in the first flow control member such that a flow rate through the fluid flow control valve may change.

Abstract: A faucet includes a body that extends between a first end and a second end, and is arranged to receive a mixing cartridge. A diaphragm valve is provided in the body, and includes a flexible diaphragm having a first side and a second side, the flexible diaphragm being moveable to open and close the diaphragm valve to control a flow of water to an outlet of the faucet. A fluid bypass, separate from the flexible diaphragm, is in fluid communication between the first side and the second side of the flexible diaphragm. A bypass valve member is moveable to open and close the fluid bypass to vary a pressure differential across the flexible diaphragm, to open and close the diaphragm valve. A push operated control member is arranged to move the bypass valve member at the second end of the body.

Abstract: Method and systems of the application using user feedback from a userbase for news and scientific research replaces a comment section or forum. Method transforms user feedback into statistical data that is less ambiguous than narrative comments and provides insight into the consensus of a userbase across different categories including, but are not limited to: location, age, gender, education, religion, or political party. Searching, grouping, and filtering digital media and related data narrows the scope of information curating a unique view of user feedback and digital media. Determining what percentage of user feedback agree or disagree with the digital media displaying or indicating which digital media causes users to submit different user feedback is just as important as the news itself.

Abstract: Secure sharing of a document on a co-browse session is implemented by causing a JavaScript implemented document viewer to create HTML5 description of a rendered view of a document's content, and transmitting the HTML5 description of the rendered view of the document content as a DOM elements on the co-browse session. The rendered view of the document is overlayed on the web page being co-browsed, which enables the participants to the co-browse session to collaboratively view the rendered view of the document. However, since the document itself only resides in the visitor's browser, the document itself is not transmitted on the co-browse session. Media URLs can also be shared, and the participants' views of the audio/video media is synchronized by causing the video to play locally at each participant but synchronized with the visitor. Live video of the participants to the co-browse session is also implemented.

Abstract: The present invention is a digital application that streamlines and provides access to public opinion of newsworthy information (FIG. 2-B) in a more granular process. It creates records by combining a user-submitted rating of digital content (FIG. 2-C) with data from a user created profile (FIG. 1-A), not limited to categories including age, race, gender, or location. A rating could include a positive rating, negative rating, a non-factual rating, or numbered score (FIG. 3-E). User's data and rating is aggregated and displayed as statistical metrics (FIG. 3-C) related to the individual digital content being viewed (FIG. 3-D) or grouped by keywords. The aggregated user data and ratings can be queried and filtered by each category (FIG. 4-H) to provide a sample poll relating to the content or topic (FIG. 5-J). Statistical outliers are identified to help determine if/where a bias exists.

Abstract: A faucet includes a body that extends between a first end and a second end, and is arranged to receive a mixing cartridge. A diaphragm valve is provided in the body, and includes a flexible diaphragm having a first side and a second side, the flexible diaphragm being moveable to open and close the diaphragm valve to control a flow of water to an outlet of the faucet. A fluid bypass, separate from the flexible diaphragm, is in fluid communication between the first side and the second side of the flexible diaphragm. A bypass valve member is moveable to open and close the fluid bypass to vary a pressure differential across the flexible diaphragm, to open and close the diaphragm valve. A push operated control member is arranged to move the bypass valve member at the second end of the body.

Abstract: An apparatus for recovering heat in an ablutionary or plumbing system includes first and second pipes for carrying fluids at different temperatures. A first heat transfer element is configured to be thermally coupled to the first pipe and a second heat transfer element configured to be thermally coupled to the second pipe, with each having an elongate portion extending in a direction away from the associated pipe. The elongate portions of the first and second heat transfer elements at least partially overlap. A thermoelectric device is provided that includes one or more thermoelectric elements located between the elongate portions, the thermoelectric element(s) being in thermal communication with the elongate portion of the first heat transfer element and the elongate portion of the second heat transfer element and being arranged to generate electricity from a temperature differential between the elongate portions of the first and second heat transfer elements.

Abstract: A mixer valve (1) comprises a body (5) extending in a first direction between a front end and a rear end. The body (5) defines a volume (5a); a thermostatic cartridge (15) is received in the volume (5a), and a diaphragm valve (21) is received in the volume (5a) between the thermostatic cartridge (15) and the rear end of the body (5). The diaphragm valve (21) is operable in response to actuation of a push operated control member (23) to control flow of water from the mixer valve (1).

Abstract: A video sender loads sender video processing JavaScript into a browser, the sender video processing JavaScript being configured to receive video from a source connected to the first computer, encode images of the video into a H.26x encoded video format, package the encoded video into WebM or FMP4 format, and output the packaged/encoded video on the communication network. A video receiver loads receiver video JavaScript in its browser, the receiver video JavaScript comprising a video format detector, a WebM deboxer, a FMP4 deboxer, a H.26x video decoder, and a rendering engine. The video format detector determines whether received video is packaged using WebM or FMP4 and sends the video to the respective deboxer. The deboxed video is then decoded using the H.26x decoder and the images are rendered by the rendering engine. Timestamps and byte counts are inserted into the video packages, and acknowledgments are used to determine excess latency.

Abstract: A bush having a neck portion (33) for inserting into an aperture of one or both of two components to be fastened together, a radially extending shoulder portion (34) having a rear face (34a) adjacent the neck portion (33) an opposite front face (34b) and a radially outer face (34c) extending between the rear face (34a) and the front face (34b), one or more ventilation slots (36) provided in the rear face extending from a junction between the rear face (34a) and the neck portion (33) whereby, in use, to provide an escape route for air caught between the bush and a component.

Abstract: An agent providing customer support to visitors on a website can co-browse with the visitors as they interact with the website. The agent is provided with a list of authorized third-party domains. Upon selection of one of the authorized third-party domains, an invitation will be sent to the visitor to co-browse with the agent on the website in the unaffiliated third-party domain. Acceptance of the invitation causes a co-browse browser extension to be downloaded to the visitor's browser and redirects the visitor's browser to the website in the third-party domain. The co-browse browser extension contains co-browse script to replicate the DOM of the visitor's browser to the agent so that the agent can view the visitor's browser as the visitor interacts with the website in the third-party domain.

Abstract: A bush having a neck portion (33) for inserting into an aperture of one or both of two components to be fastened together, a radially extending shoulder portion (34) having a rear face (34a) adjacent the neck portion (33) an opposite front face (34b) and a radially outer face (34c) extending between the rear face (34a) and the front face (34b), one or more ventilation slots (36) provided in the rear face extending from a junction between the rear face (34a) and the neck portion (33) whereby, in use, to provide an escape route for air caught between the bush and a component.

Abstract: An electronic device is described which comprises a memory storing a font comprising a mapping from character codes to glyphs. The memory also stores character information comprising at least information about one or more unsupported character codes. A processor of the device processes text content comprising character codes using the font to create text output by converting the character codes into glyphs for display at a display associated with the electronic device. The processor is configured to capture the text output and detect whether the text output comprises at least one unsupported character code; and, in the case that at least one unsupported character code is detected, to output to a user of the device information about the unsupported character code obtained from the character information.