Abstract: 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

Abstract: A method is provided for operating a hybrid vehicle equipped with an internal-combustion engine and an electric drive for generating vehicle propulsion. The vehicle selectively is driven in a first operating mode exclusively by the electric drive or in a second operating mode is driven by the internal combustion engine and by the electric drive, or in a third operating mode is driven exclusively by the internal combustion engine. In the first operating mode, the driver predefines a desired driving torque via a selection element. The first operating mode is maintained even if the desired driving torque is greater than a maximal driving torque that can presently be supplied by the electric motor.

Abstract: An operating device for a household appliance includes an electronic display panel, and an operating element that is displaceable relative to the display panel to set operating conditions of the household appliance. The operating element has a region which is disposed within an area of the display panel.

Abstract: 5-alkynyl-pyridine of general formula (I) which are inhibitors of the activity of PI3K alpha, and their use in the treatment of diseases characterized by excessive or abnormal cell proliferation, such as cancer.

Abstract: 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification.

Abstract: 5-alkynyl-pyridine of general formula (I) which are inhibitors of the activity of PI3K alpha, and their use in the treatment of diseases characterized by excessive or abnormal cell proliferation, such as cancer.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.

Abstract: A filter unit for an extractor hood includes at least one filter element, and at least one protection plate which is arranged in a flow direction upstream of the filter element. The protection plate is made of at least two layers and can have a thickness in a range of 0.5 mm to 10 mm.

Abstract: The present invention relates to the field of multi-path wireless communication. The present invention provides a system for assisting in providing a wireless communication link between a first communication device and a second communication device based on a plurality of communication paths comprising a history manager for providing, based on a recorded history of communication path states, a proposal for one or more communication paths based on which the communication link can be provided. The present invention further provides a corresponding method and a communication system and a communication device comprising the system of the present invention. Based on the proposal provided by the present invention, path switching can be performed more effectively, less and shorter interruptions of the communication link can be obtained and an enhanced transmission quality can be provided for multi-path wireless communication systems.

Abstract: The present invention encompasses compounds of general Formula (1) wherein R2, R3, Q, W, X, Y and Z are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1, M1, L1 and Q are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract: The present invention encompasses compounds of general Formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

Abstract: A heterogeneous wireless network topology suited for low-power, short-range and ubiquitous ad-hoc communication. The network topology integrates different wireless transmission technologies, in particular to a wireless sensor network including different node types and communication technologies. The network is highly heterogeneous and can be operated according to the master-slave principle. The nodes can have different wireless communication means tailored to their individual role in the network and other constraints, thus allowing different communication patterns.

Abstract: The present invention relates to a transmitting device (1) for transmitting signals in a wireless communication system, wherein said signals are transmitted in consecutive frames (23a, 23b, 23c), each frame comprising a beacon (BSF) and data frames (DF), said transmitting device (1) comprising a first set of narrow beam antennas (2a, 2b, 2c), each narrow beam antenna (2a, 2b, 2c) having a different beaming direction corresponding to one of a number of different transmission paths (P0, P1, P2) from said transmitting device (1) to a receiving device, and a first control means (5) adapted to control the transmission of said frames (23a, 23b, 23c), whereby the data frames (DF) of respectively two consecutive frames (23a, 23b, 23c) are transmitted via different narrow beam antennas (2a, 2b, 2c).

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract: The present invention encompasses compounds of general Formula (1) wherein R2, R3, Q, W, X, Y and Z are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.