Abstract: The present invention relates to methods and pharmaceutical compositions for treating vaso-occlusive crises. In particular, the present invention relates to a method of treating a vaso-occlusive crisis in a subject in need thereof comprising administering to the subject a therapeutically effective amount of agent capable of degrading, destabilizing or depleting the blood-borne extracellular DNA from the blood of the subject.

Abstract: A glazing includes a glazed element, at least one profiled seal portion and at least one insert which is located at least partially inside the profiled seal portion, the insert having along a main portion which is in the profiled seal portion, in cross-section, a section which is closed on itself in the form of a loop and which forms a hollow member, wherein the main portion includes at least at one end a stopper which closes the end.

Abstract: The present invention relates to a hook fastener including a base strip and a field of hooks, each hook comprising a stem and a cap, said cap including at least one lateral overhang, and each hook being further delimited by two opposing substantially planar surfaces, wherein the overhang comprises a swelling located at a distance from the stem so that the thickness of the overhang increases in said swelling, the bottom surface of the overhang forming a cavity for receiving filaments.

Abstract: The present invention relates to an in vitro method for preparing progenitor cells having an increased adhesivity, wherein progenitor cells are contacted with an agonist of the CD47/IAP receptor thereby yielding progenitor cells presenting an increased adhesivity.

Abstract: The invention relates to an applicator device for liquid or volatile products, having a product reservoir (1), a neck (14) of which contains a part (16) for diffusing or applying the product; a cartridge (2), provided with a neck (24), for holding the reservoir (1), the cartridge being designed such that the reservoir can take up a first position in which the application and diffusion part does not protrude from the neck and a second position in which this part protrudes from the neck; and a receptacle (3) for the cartridge (2), said receptacle being provided with means for causing the reservoir to move from the first position to the second when the cartridge is in the receptacle.

Abstract: A connecting rod is composed of two or more assembled shells made of a composite, open over the entire length of the connecting rod. The shells incorporate clevis joints for introducing stress at each of their ends. The shells are produced separately then assembled together to form a sealed section. Each shell is made from a material preimpregnated with long fibres. The production of each shell is simplified due to the overall shape of the shell as a simple curve, thus a shell may be produced industrially, for example, by thermoforming a flat composite preform. The two shells are assembled by simultaneous polymerization of the shells, by bonding, by welding, by riveting or any other assembly process or combination of assembly processes that are compatible with one another. The structural composite connecting rod obtained has very good mechanical properties, especially in compression, with a simple and economic production process.

Abstract: The present invention relates to methods for determining the risk of severe complications in hemolytic diseases. The present invention relates to a method for determining whether a patient suffering from sickle cell disease is at risk for a vaso-occlusive crisis comprising the steps consisting of i) determining the level of cell microparticles in a blood sample obtained from said patient and ii) determining the level of heme and/or hemoglobin contained in said cell microparticles. The present invention also relates to a method for a method the severe complication in hemolytic diseases comprising the steps consisting of i) determining the level of cell microparticles in a blood sample obtained from said patient and ii) determining the level of heme and/or hemoglobin contained in said cell microparticles.

Abstract: There is provided a vertical axis wind turbine comprising an upright rotatable shaft mountable on a support structure, a plurality of upright blades, and a plurality of prestressable supporting arms for attaching the plurality of blades to the shaft. The wind turbine may further comprise a shaft stabilizing assembly comprising a plurality of coplanar wheels having compliant outer layers, rotatably mounted on a support, for radially and rotatably supporting a rotatable shaft. The disclosure further provides a method of assembly of the wind turbine.

Abstract: A connecting rod is composed of two or more assembled shells made of a composite, open over the entire length of the connecting rod. The shells incorporate clevis joints for introducing stress at each of their ends. The shells are produced separately then assembled together to form a sealed section. Each shell is made from a material preimpregnated with long fibres. The production of each shell is simplified due to the overall shape of the shell as a simple curve, thus a shell may be produced industrially, for example, by thermoforming a flat composite preform. The two shells are assembled by simultaneous polymerization of the shells, by bonding, by welding, by riveting or any other assembly process or combination of assembly processes that are compatible with one another. The structural composite connecting rod obtained has very good mechanical properties, especially in compression, with a simple and economic production process.

Abstract: The present invention relates to an in vitro method for preparing progenitor cells having an increased adhesivity, wherein progenitor cells are contacted with an agonist of the CD47/IAP receptor thereby yielding progenitor cells presenting an increased adhesivity.