Abstract: The invention provides a cosmetic or therapeutic method for combating canities and/or stimulating natural pigmentation and/or treating a pigmentation disorder comprising administering at least one polynucleotide fragment comprising 18 consecutive nucleotides, the sequence of which corresponds to all or part of a gene on human chromosome 3 selected from KIAA 042, CCK, CACNA1D, ARHGEF3 and AL133097 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 5 selected from the KLHL3, HNRPA0, CDC25C, EGR1, C5orf6, C5orf7, LOC51308, ETF1, HSPA9B, PCDHA1 to PCDHA13, CSF1R, RPL7, PDGFRB, TCOF1, AL133039, CD74, RPS14, NDST1, G3BP, GLRA1, C5orf3, MFAP3, GALNT10 and FLJ 117151 genes, or the sequence of which corresponds to all or part of a gene on human chromosome 11 selected from the GUCY1A2, CUL5, ACAT1, NPAT, ATM, AF035326, AF035327, AF035328, BC029536, FLJ20535, DRD2, ENS303941, IGSF4, LOC51092, BC010946, TAGLN, PCSK7 and ENS300650 genes, and diagnostic methods employing same.

Abstract: The invention relates to new non-therapeutic methods allowing the level of skin neurosensitivity and/or the state of neurosensorial skin reactivity of an individual to be evaluated by applying a peripheral nervous system stimulant to one skin area, the method being implemented under conditions of safety and comfort acceptable for the user, irrespective of his or her skin type.

Abstract: One aspect of the present invention relates to methods of generating a profile data set. In an exemplary embodiment, data is accessed and the accessed data is processed using a dynamic cluster method, mobile center method, and/or a k-means algorithm, each using neighborhood data. Other aspects relate to methods of generating a diagnosis, advice, and/or other information. Further aspects relate to dynamic surveying and systems.

Abstract: The present invention relates to the use of DHEA and/or of at least one precursor or derivative thereof in or for the manufacture of a composition for topical application to the skin, as an agent for preventing or reducing the weathered appearance of the skin.

Abstract: Agonists of chlorine/potassium channel receptor, for example taurine, gamma-aminobutyric acid (GABA), isoguvacin, isonipecotic acid, 4,5,6,7-tetrahydroisoxazolo-(5,4-c)pyrid-3(2H)-one, a benzodiazepine, steroids, and cromakalim, pinacidil, nicorandil and minoxidil, are well suited for treating sensitive human skin and are especially useful for treating/eliminating skin itching, pruritus, tautness, tingling and/or erythema.

Abstract: The growth of body and/or head/cranial hair on mammalian organisms, for example humans, is modulated by administering thereto, whether topically and/or systemically, therapeutically effective amounts of at least one lipoxygenase or cyclooxygenase inhibitor, or at least one lipoxygenase or cyclooxygenase stimulator, preferably in the presence of at least one lipoxygenase/cyclooxygenase substrate or precursor thereof; when a hair-growth or hair loss-limiting response is sought to be elicited, a lipoxygenase inhibitor and/or cyclooxygenase stimulator is administered (conversely, to reduce or prevent hair growth, a lipoxygenase stimulator and/or cyclooxygenase inhibitor is administered).

Abstract: Use to partially or totally reduce the symptoms associated with histamine release in the organism, particularly pruritus and erythema, which comprises the topical application of a cosmetic and/or dermatological and/or hygiene composition containing an effective quantity of at least one ion chelating agent, said composition being essentially free of flavones, flavonones and/or flavonoids, and free of sequestring agents such as polyaspartic acid and its salts, cellulose derivatives and copolymers containing maleic or hydrosuccinic acid as monomeric building blocks and salts thereof.

Abstract: Use of a cosmetic and/or dermatological and/or hygiene composition containing an effective quantity of at least one ion chelating agent for increasing the tolerance threshold of sensitive or intolerant skin

Abstract: Skin redness, rosacea and/or discreet erythema afflicting a mammalian, notably human patient, are therapeutically treated by administrating to such patient a therapeutically/cosmetically effective amount of at least one CGRP antagonist, advantageously in combinatory immixture with at least one antagonist of a neuropeptide other than CGRP, e.g., a substance P antagonist, and/or at least one inflammation mediator antagonist.

Abstract: Cosmetic/dermatological compositions suited for combating the adverse signs of cutaneous skin aging, notably for maintaining and/or enhancing the thickness of the skin, particularly the thickness of the epidermis, comprise a thus-effective amount of at least one substance/species which is active with respect to the trophicity of the cutaneous nerves and/or at least one neurostimulant and/or at least one neuroactivator and/or at least one neuromediator, formulated into a cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor.

Abstract: The subject of the present invention, in its most general aspect, is an extract of cells of at least one plant of the Iridaceae family, the said plant being obtained by in vitro culture. The subject of the invention is also compositions containing an extract of cells of at least one plant of the Iridaceae family, the use of the said extracts as antagonist of CGRP and/or of substance P and a process of cosmetic treatment involving one of the said compositions.

Abstract: The growth of body and/or head/cranial hair on mammalian organisms, for example humans, is modulated by administering thereto, whether topically and/or systemically, therapeutically effective amounts of at least one lipoxygenase or cyclooxygenase inhibitor, or at least one lipoxygenase or cyclooxygenase stimulator, preferably in the presence of at least one lipoxygenase/cyclooxygenase substrate or precursor thereof; when a hair-growth or hair loss-limiting response is sought to be elicited, a lipoxygenase inhibitor and/or cyclooxygenase stimulator is administered (conversely, to reduce or prevent hair growth, a lipoxygenase stimulator and/or cyclooxygenase inhibitor is administered).

Abstract: Topically applicable pharmaceutical/dermatological/cosmetic compositions well suited for the therapeutic treatment or care of sensitive human skin, hair, mucous membranes, nails and/or the scalp, in particular for reducing or avoiding the skin-irritant side effects of a variety of bioactive agents, for example the &agr;-hydroxy acids, comprise a therapeutically/cosmetically effective amount of at least one calcitonin gene related peptide (“CGRP”) antagonist, e.g., CGRP 8-37 or an anti-CGRP antibody.

Abstract: The invention relates to the use of a substance P antagonist for the preparation of a pharmaceutical composition, in particular for topical application, for treating lichens, prurigo, pruriginous toxicoderma and severe pruritus of neurogenic origin.

Abstract: The invention is directed to a method for preventing or treating the symptoms associated with sensitive skin by applying an effective amount of at least one nitric oxide synthase inhibitor to treat or prevent the symptoms associated with sensitive skin to an individual in need thereof.

Abstract: Cosmetic/pharmaceutical compositions for promoting hair growth and/or retarding hair loss, and/or for increasing the mean diameter of strands of hair and/or decreasing the heterogeneity thereof, and/or for increasing hair density, and/or for improving the quality and/or the appearance of a head of hair, and/or for inducing repigmentation of the hair, contain thus effective amounts of intimate admixture of vitamin A, vitamin C, vitamin E, and zinc and selenium values.

Abstract: Ocular and/or palpebral pruritus and/or ocular and/or palpebral pain and/or ocular and/or palpebral dysaesthesia afflicting a mammalian, notably human patient, are therapeutically treated by administering to such patient a therapeutically/cosmetically effective amount of at least one CGRP antagonist, advantageously in combinatory immixture with at least one antagonist of a neuropeptide other than CGRP, e.g., a substance P antagonist, and/or at least one inflammation mediator antagonist; the subject compositions are also well suited for making up and/or caring for human eyes, eyelashes and/or eyelids, especially sensitive eyes and eyelids.

Abstract: Topically applicable pharmaceutical/dermatological/cosmetic compositions well suited for the therapeutic treatment or care of sensitive human skin, hair, mucous membranes, nails and/or the scalp, in particular for reducing or avoiding the skin-irritant side effects of a variety of bioactive agents, for example the &agr;-hydroxy acids, comprise a therapeutically/cosmetically effective amount of at least one calcitonin gene related peptide (“CGRP”) antagonist, e.g., CGRP 8-37 or an anti-CGRP antibody.

Abstract: Topically applicable pharmaceutical/dermatological/cosmetic compositions well suited for the therapeutic treatment or care of sensitive human skin, hair, mucous membranes, nails and/or the scalp, in particular for reducing or avoiding the skin-irritant side effects of a variety of bioactive agents, for example the &agr;-hydroxy and &bgr;-hydroxy acids, comprise a therapeutically/cosmetically effective amount of at least one bradykinin antagonist.

Abstract: The invention relates to the use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF-alpha antagonist in a cosmetic, pharmaceutical or dermatological composition for treating sensitive skins. It relates especially to the use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF-alpha antagonist for preventing and/or combating skin irritations and/or sores and/or erythema and/or dysaesthesic sensations and/or sensations of inflammation and/or pruritus and/or prickling and/or tingling and/or discomfort and/or tightness of the skin and/or mucosae. It also relates to a composition containing a histamine antagonist, an interleukin-1 antagonist and/or a TNF-alpha antagonist which limits or eliminates the irritant side-effects of certain products, and in particular of certain cosmetic, dermatological or pharmaceutical active agents.