Patents by Inventor Olivier Roche

Olivier Roche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLOHEXYL DERIVATIVES
    Publication number: 20090005380
    Abstract: The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: June 10, 2008
    Publication date: January 1, 2009
    Inventors: Delphine Gaufreteau, Matthias Nettekoven, Jean-Marc Plancher, Olivier Roche, Sebastien Schmitt, Tadakatsu Takahashi
  • Azaindole-2-Carboxamide Derivatives
    Publication number: 20090005379
    Abstract: The present invention relates to compounds of formula (I) wherein R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: November 8, 2006
    Publication date: January 1, 2009
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Hans Richter, Olivier Roche, Sven Taylor
  • Piperazinyl-pyridine derivatives
    Patent number: 7456175
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: November 25, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: Matthias Heinrich Nettekoven, Olivier Roche, Rosa Maria Rodriguez-Sarmiento
  • 5-aminoindole derivatives as H3 inverse agonists
    Patent number: 7456174
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, R4 and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: November 25, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Matthias Heinrich Nettekoven, Jean-Marc Plancher, Olivier Roche, Rosa Maria Rodriguez-Sarmiento
  • MALONAMIDES AS OREXIN ANTAGONISTS
    Publication number: 20080249180
    Abstract: The present invention relates to compounds of formula I wherein Ar1, Ar2, R, R1, R2, R3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved like sleep disorders.
    Type: Application
    Filed: March 7, 2008
    Publication date: October 9, 2008
    Inventors: Luca Gobbi, Henner Knust, Parichehr Malherbe, Matthias Nettekoven, Emmanuel Pinard, Olivier Roche, Mark Rogers-Evans
  • HETEROCYCLIC DERIVATIVES AS OREXIN ANTAGONISTS
    Publication number: 20080249125
    Abstract: The present invention relates to compounds of formula wherein R1, R2, R3, and R4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring system, connected to the carbon atoms of the piperidine group selected from the group consisting of or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders in which orexin pathways are involved, like sleep disorders.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 9, 2008
    Inventors: Luca Gobbi, Henner Knust, Parichehr Malherbe, Matthias Nettekoven, Emmanuel Pinard, Olivier Roche, Mark Rogers-Evans
  • 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
    Patent number: 7432255
    Abstract: The present invention relates to compounds of formula I and their pharmaceutically acceptable salts wherein in formula I is: wherein R1 to R4 are as defined in the description and claims. The compounds of the present invention are useful for the treatment and/or prevention of diseases which are associated with the modulation of histamine 3 (H3) receptors.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: October 7, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Matthias Heinrich Nettekoven, Olivier Roche
  • AMINOAMIDES AS OREXIN ANTAGONISTS
    Publication number: 20080221166
    Abstract: The present invention relates to compounds of formula I wherein Ar1, Ar2, Ar3, n, and R1 to R8 are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved, like sleep disorders.
    Type: Application
    Filed: February 27, 2008
    Publication date: September 11, 2008
    Inventors: Luca Gobbi, Henner Knust, Parichehr Malherbe, Matthias Nettekoven, Emmanuel Pinard, Olivier Roche, Mark Rogers-Evans
  • INDOL-2-YL-PIPERAZIN-1-YL-METHANONE DERIVATIVES
    Publication number: 20080188484
    Abstract: The present invention relates to compounds of formula I wherein A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: January 25, 2008
    Publication date: August 7, 2008
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Hans Richter, Olivier Roche, Sven Taylor
  • (INDOL-4-YL) OR (INDOL-5-YL)-PIPERAZINYLMETHANONES
    Publication number: 20080188486
    Abstract: The present invention relates to compounds of formula I wherein one of R1 and R2 is hydrogen and the other one is and wherein A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: January 23, 2008
    Publication date: August 7, 2008
    Inventors: Matthias Nettekoven, Olivier Roche
  • 5-AMIDO-(1H-INDOL-2-YL)-PIPERAZIN-1-YL-METHANONE DERIVATIVES
    Publication number: 20080188487
    Abstract: The present invention relates to compounds of formula I wherein A, G and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: January 28, 2008
    Publication date: August 7, 2008
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Hans Richter, Olivier Roche, Sven Taylor
  • 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
    Publication number: 20080146559
    Abstract: The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: November 20, 2007
    Publication date: June 19, 2008
    Inventors: Li Chen, Wayne Wen Lai, Matthias Nettekoven, Olivier Roche, Deye Zheng
  • 4,5,6,7-Tetrahydro-Thieno [3,2-C] Pyridine Derivatives
    Publication number: 20080146558
    Abstract: The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: November 20, 2007
    Publication date: June 19, 2008
    Inventors: Li Chen, Wayne Wen Lai, Matthias Nettekoven, Olivier Roche, Deye Zheng
  • 5-substituted indole-2-carboxamide derivatives
    Patent number: 7388095
    Abstract: The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: June 17, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Hans Richter, Olivier Roche, Sven Taylor
  • ETHER DERIVATIVES
    Publication number: 20080103174
    Abstract: The present invention relates to ether derivatives according to general formula I, and to their pharmaceutically-acceptable salts, which may be used in treating or preventing cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, or psychoses comprising paranoia and delusions.
    Type: Application
    Filed: October 22, 2007
    Publication date: May 1, 2008
    Inventors: Luca Gobbi, Georg Jaeschke, Olivier Roche, Rosa Rodriguez Sarmiento, Lucinda Steward
  • Indole derivatives as H3 inverse agonists
    Patent number: 7361682
    Abstract: The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: April 22, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Cornelia Hertel, Matthias Heinrich Nettekoven, Susanne Raab, Olivier Roche, Rosa Maria Rodriguez-Sarmiento, Franz Schuler, Jean-Marc Plancher
  • Pyrrolo [2,3-b] pyridine derivatives
    Patent number: 7351708
    Abstract: The present invention relates to compounds of formula I wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: April 1, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Matthias Nettekoven, Olivier Roche
  • Pyrrolo [2,3-c] pyridine derivatives
    Patent number: 7348323
    Abstract: The present invention relates to compounds of formula I wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: March 25, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Matthias Nettekoven, Olivier Roche
  • 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
    Publication number: 20080032976
    Abstract: The present invention relates to the compounds of formula I: wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: July 19, 2007
    Publication date: February 7, 2008
    Inventors: Matthias Nettekoven, Olivier Roche
  • Piperidinyl pyrimidine derivatives
    Publication number: 20070281921
    Abstract: The present invention relates to compounds of formula I and their pharmaceutically acceptable salts wherein formula I is: wherein X, Y, Z, R1 and R2 are as defined in the description and claims. The compounds of the present invention act as antagonists and/or inverse agonists at the histamine 3 receptor and are useful for the treatment and/or prevention of diseases such as obesity, metabolic syndrome (syndrome X), and other eating disorders.
    Type: Application
    Filed: May 21, 2007
    Publication date: December 6, 2007
    Inventors: Matthias Heinrich Nettekoven, Olivier Roche