Patents by Inventor Olivier Roche

Olivier Roche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IH-indol-5-YL-piperazin-1-YL-methanone derivatives
    Publication number: 20070270423
    Abstract: The present invention relates to compounds of formula I and their pharmaceutically acceptable salts wherein in formula I is: wherein R1 to R4 are as defined in the description and claims. The compounds of the present invention are useful for the treatment and/or prevention of diseases which are associated with the modulation of histamine 3 (H3) receptors.
    Type: Application
    Filed: April 26, 2007
    Publication date: November 22, 2007
    Inventors: Matthias Heinrich Nettekoven, Olivier Roche
  • Naphthaline derivatives as H3 inverse agonists
    Publication number: 20070265254
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: June 22, 2007
    Publication date: November 15, 2007
    Inventors: Silvia McArthur, Cornelia Hertel, Matthias Nettekoven, Jean-Marc Plancher, Susanne Raab, Olivier Roche, Rosa Rodriguez-Sarmiento, Franz Schuler
  • Novel diazepan derivatives
    Publication number: 20070249589
    Abstract: The invention is concerned with novel diazepan derivatives of formula (I) wherein A, X, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.
    Type: Application
    Filed: April 19, 2007
    Publication date: October 25, 2007
    Inventors: Johannes Aebi, Luke Green, Patrizio Mattei, Fabienne Ricklin, Olivier Roche, Peter Zahm
  • 5-amido-indole-2-carboxamide derivatives
    Publication number: 20070244125
    Abstract: The present invention relates to compounds of formula I wherein G and R1 to R5 and R12 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: April 5, 2007
    Publication date: October 18, 2007
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Hans Richter, Olivier Roche, Sven Taylor
  • Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors
    Publication number: 20070197531
    Abstract: The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.
    Type: Application
    Filed: February 13, 2007
    Publication date: August 23, 2007
    Inventors: Luca Gobbi, Georg Jaeschke, Thomas Luebbers, Olivier Roche, Rosa Rodriguez Sarmiento, Lucinda Steward
  • Naphthaline derivatives as H3 inverse agonists
    Patent number: 7259158
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: August 21, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Gatti McArthur, Cornelia Hertel, Matthias Heinrich Nettekoven, Jean-Marc Plancher, Susanne Raab, Olivier Roche, Rosa Maria Rodriguez-Sarmiento, Franz Schuler
  • Cyclohexyl sulfonamide derivatives
    Publication number: 20070173511
    Abstract: The present invention relates to compounds of formula I wherein R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: January 16, 2007
    Publication date: July 26, 2007
    Inventors: Matthias Nettekoven, Olivier Roche
  • Cyclohexyl piperazinyl methanone derivatives
    Publication number: 20070167436
    Abstract: The present invention relates to compounds of formula I wherein s, R1a and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: January 4, 2007
    Publication date: July 19, 2007
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Olivier Roche, Tadakatsu Takahashi, Sven Taylor
  • Pyrrolo [2,3-c] pyridine derivatives
    Publication number: 20070142359
    Abstract: The present invention relates to compounds of formula I wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: December 6, 2006
    Publication date: June 21, 2007
    Inventors: Matthias Nettekoven, Olivier Roche
  • Pyrrolo [2,3-B] pyridine derivatives
    Publication number: 20070142358
    Abstract: The present invention relates to compounds of formula I wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: December 6, 2006
    Publication date: June 21, 2007
    Inventors: Matthias Nettekoven, Olivier Roche
  • Tricyclic amide derivatives
    Publication number: 20070135416
    Abstract: The present invention relates to compounds of formula I wherein A, G, r and R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: November 29, 2006
    Publication date: June 14, 2007
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Hans Richter, Olivier Roche, Sven Taylor
  • 5-Substituted indole-2-carboxamide derivatives
    Publication number: 20070123525
    Abstract: The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: November 27, 2006
    Publication date: May 31, 2007
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Hans Richter, Olivier Roche, Sven Taylor
  • 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives
    Publication number: 20070123526
    Abstract: The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: November 28, 2006
    Publication date: May 31, 2007
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Hans Richter, Olivier Roche, Rosa Rodriguez Sarmiento, Sven Taylor
  • Thiazolyl piperidine derivatives
    Publication number: 20070043083
    Abstract: The present invention relates to compounds of formula I wherein R1, R2 and R3 are as defined in the description and claims. It further relates to pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: August 10, 2006
    Publication date: February 22, 2007
    Inventors: Matthias Nettekoven, Olivier Roche
  • 5-Aminoindole derivatives as H3 inverse agonists
    Publication number: 20060160855
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, R4 and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: January 17, 2006
    Publication date: July 20, 2006
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Olivier Roche, Rosa Rodriguez-Sarmiento
  • Piperazinyl-pyridine derivatives
    Publication number: 20060135528
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: December 12, 2005
    Publication date: June 22, 2006
    Inventors: Matthias Nettekoven, Olivier Roche, Rosa Rodriguez-Sarmiento
  • Pyridine derivatives as H3 antagonists
    Publication number: 20060122187
    Abstract: The present invention relates to compounds of formula I wherein R1, R2 and A are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: November 30, 2005
    Publication date: June 8, 2006
    Inventors: Matthias Nettekoven, Olivier Roche, Rosa Rodriguez-Sarmiento
  • Quinoline derivatives as H3R inverse agonists
    Publication number: 20060084679
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: October 14, 2005
    Publication date: April 20, 2006
    Inventors: Silvia McArthur, Cornelia Hertel, Matthias Nettekoven, Susanne Raab, Hans Richter, Olivier Roche, Rosa Rodriguez-Sarmiento, Franz Schuler
  • Naphthaline derivatives as H3 inverse agonists
    Publication number: 20060009449
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: June 1, 2005
    Publication date: January 12, 2006
    Inventors: Silvia McArthur, Cornelia Hertel, Matthias Nettekoven, Jean-Marc Plancher, Sussanne Raab, Olivier Roche, Rosa Rodriguez-Sarmiento, Franz Schuler
  • Indole derivatives as H3 inverse agonists
    Publication number: 20050282864
    Abstract: The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Application
    Filed: June 20, 2005
    Publication date: December 22, 2005
    Inventors: Silvia McArthur, Cornelia Hertel, Matthias Nettekoven, Susanne Raab, Olivier Roche, Rosa Rodriguez-Sarmiento, Franz Schuler, Jean Marc Plancher