Patents by Inventor Omar KHDOUR
Omar KHDOUR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240409521Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 has any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as cytoprotective agents.Type: ApplicationFiled: September 14, 2021Publication date: December 12, 2024Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Omar KHDOUR, Sidney HECHT, Jun LIU, Indrajit BANDYOPADHYAY
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Publication number: 20230295101Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.Type: ApplicationFiled: November 29, 2022Publication date: September 21, 2023Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney HECHT, Omar KHDOUR, Sandipan Roy CHOWDHURY, Nishant P. VISAVADIYA
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Patent number: 11560360Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscript m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.Type: GrantFiled: July 9, 2020Date of Patent: January 24, 2023Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Nishant P. Visavadiya
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Publication number: 20220324841Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.Type: ApplicationFiled: June 15, 2022Publication date: October 13, 2022Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney HECHT, Omar KHDOUR, Arnaud CHEVALIER
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Patent number: 11390605Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.Type: GrantFiled: August 18, 2017Date of Patent: July 19, 2022Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney Hecht, Omar Khdour, Arnaud Chevalier
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Publication number: 20220081404Abstract: The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.Type: ApplicationFiled: April 28, 2021Publication date: March 17, 2022Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney HECHT, Omar KHDOUR, Sandipan Roy CHOWDHURY, Indrajit BANDYOPADHYAY
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Patent number: 11203583Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.Type: GrantFiled: February 6, 2020Date of Patent: December 21, 2021Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Arnaud Chevalier, Omar Khdour, Yanmin Zhang, Sidney Hecht
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Publication number: 20210276979Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.Type: ApplicationFiled: August 18, 2017Publication date: September 9, 2021Applicant: Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Sidney HECHT, Omar KHDOUR, Arnaud CHEVALIER
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Patent number: 11034662Abstract: The invention provides compounds formula (I) and salts thereof: wherein R1, R2, R3, R6 and Y have any of the values defined in the specification. The compounds are useful for treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.Type: GrantFiled: October 21, 2019Date of Patent: June 15, 2021Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Indrajit Bandyopadhyay
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Publication number: 20200407333Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscript m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.Type: ApplicationFiled: July 9, 2020Publication date: December 31, 2020Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney HECHT, Omar KHDOUR, Sandipan Roy CHOWDHURY, Nishant P. VISAVADIYA
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Patent number: 10745366Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.Type: GrantFiled: August 24, 2017Date of Patent: August 18, 2020Assignee: ARIZON BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Nishant P Visavadiya
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Publication number: 20200247775Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.Type: ApplicationFiled: February 6, 2020Publication date: August 6, 2020Inventors: Arnaud CHEVALIER, Omar KHDOUR, Yanmin ZHANG, Sidney HECHT
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Publication number: 20200115355Abstract: The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.Type: ApplicationFiled: October 21, 2019Publication date: April 16, 2020Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney HECHT, Omar KHDOUR, Sandipan Roy CHOWDHURY, Indrajit BANDYOPADHYAY
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Patent number: 10604501Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.Type: GrantFiled: June 13, 2017Date of Patent: March 31, 2020Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Arnaud Chevalier, Omar Khdour, Yanmin Zhang, Sidney Hecht
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Patent number: 10472340Abstract: The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.Type: GrantFiled: February 17, 2016Date of Patent: November 12, 2019Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Indrajit Bandyopadhyay
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Publication number: 20190330176Abstract: The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.Type: ApplicationFiled: June 13, 2017Publication date: October 31, 2019Inventors: Amaud CHEVALIER, Omar KHDOUR, Yanmin ZHANG, Sindey HECHT
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Patent number: 10364227Abstract: Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I are disclosed.Type: GrantFiled: February 17, 2016Date of Patent: July 30, 2019Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney Hecht, Omar Khdour, Mohammad Alam, Sriloy Dey, Yana Chen, Arnaud Chevalier
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Publication number: 20190185441Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.Type: ApplicationFiled: August 24, 2017Publication date: June 20, 2019Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney HECHT, Omar KHDOUR, Sandipan Roy CHOWDHURY, Nishant P VISAVADIYA
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Publication number: 20180319751Abstract: Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I are disclosed.Type: ApplicationFiled: February 17, 2016Publication date: November 8, 2018Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Sidney HECHT, Omar KHDOUR, Mohammad ALAM, Sriloy DEY, Yana CHEN, Arnaud CHEVALIER
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Patent number: 9957214Abstract: The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R1-R4 have any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal.Type: GrantFiled: October 10, 2013Date of Patent: May 1, 2018Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Manikandadas Mathilakathu Madathil, Omar Khdour, Sidney Hecht
