Abstract: The present invention relates to salts of a HPK1 inhibitor (referred to as “Compound A” hereinafter), preferably citrate, and the crystalline forms thereof. The present invention also relates to the process of preparation and uses of the salts and crystalline forms of Compound A.

Abstract: In a method for preparing an aryl carbon glycoside compound including a gliflozin drug, a sulfinate glycosyl donor represented by formula W is used as a raw material to prepare the aryl carbon glycoside compound including the gliflozin drug. The method does not need to use an additional initiator.

Abstract: A DNA library sequence for increasing the number of chip probes and an application thereof. The DNA library sequence comprises two or more position information labeling sequences and three or more fixed sequences, wherein the position information labeling sequences and the fixed sequences are arranged at intervals. The DNA library sequence increases the number of probes of a chip used for spatiotemporal omics, and then a capture number of transcript genes is increased. The present invention has a very high application prospect.

Abstract: Provided is an engineered polypeptide capable of catalyzing the asymmetric hydrolysis of 3-isobutylglutarimide to generate (R)-(?)-3-(carbamoylmethyl)-5-methylhexanoic acid. The engineered polypeptide has high stereoselectivity, high catalytic activity, good process stability and thermal stability, and tolerance to high product concentrations, and has good prospects for industrial applications.

Abstract: A computing device learns a best topological order vector for a plurality of variables. (A) A topological order vector is defined. (B) A target variable and zero or more input variables are defined based on the topological order vector. (C) A machine learning model is trained with observation vectors using values of the target variable and the zero or more input variables. (D) The machine learning model is executed with second observation vectors using the values of the target variable and the zero or more input variables to compute a loss value. (E) (A) through (D) are repeated a plurality of times. Each topological order vector defined in (A) is unique in comparison to other topological order vectors defined in (A). The best topological order vector is determined based on a comparison between the loss values computed for each topological order vector in (D).

Abstract: Provided herein are methods of assaying a methylated DNA-binding protein comprising contacting methylated DNA-binding proteins with labeled oligonucleotides, obtaining sample partitions for oligonucleotides with different methylation states, and quantifying the labeled oligonucleotides in the partitions.

Abstract: The present invention discloses a semi-aromatic polyester, and a preparation method therefor and an application thereof. The semi-aromatic polyester has a specific scope of double bond content. Compared with the existing semi-aromatic polyester, the semi-aromatic polyester of the present invention has better melting heat retention stability and fine color.

Abstract: A microfluidic EP device for exogenous molecules transfection is disclosed that has high speed, high viability, and efficiency for collection of cells after EP. The microfluidic EP device has an EP chamber assembly, an adaptor, a pop up device, a syringe pump assembly, an EP controller, and a system controller. The EP chamber assembly has a MEMS nano channel plate, a MEMS cap, a cell cavity plate, and a cell cavity plate holder. The EP chamber assembly is connected to the pop up device through the adaptor. The pop up device may be an ultrasound vibrator or a motorized rotator. The MEMS cap has inlets/outlets for inputting/outputting cell solution, washing solution, transfected cells, exogenous material solution. The solution fluid is inputted/outputted by plastic tube and needle adaptor to the syringe pump assembly. All operation sequences are controlled by the system controller, which may perform batch operation continuously.

Abstract: The invention relates to a knitted fabric, a knitting method and a glove. The knitted fabric includes a first face and a second face which are oppositely arranged, and at the edge joint between the first face and the second face, a first yarn joint is formed through the connection between the first loop of the nth first loop row and the first loop of the (n+1)th first loop row, and a second yarn joint is formed through the connection between the second loop of the nth second loop row and the second loop of the (n+1)th second loop row, and the first yarn joint and the second yarn joint interlock with each other to form an interlocked part to connect the first face and the second face.

Abstract: This disclosure provides a fiber filling nonwoven, consisting essentially of at least one fiber web and first fiber balls. Parts of the first fiber balls are directly fixed on the at least one fiber web, and another parts of the first fiber balls are indirectly fixed on the at least one fiber through being fixed on the parts of the first fiber balls. The first fiber ball includes first hollow polyester fibers having a first crimp number and second hollow polyester fibers having a second crimp number, and the first polyester hollow fibers and the second polyester hollow fibers are inelastic hollow polyester fibers with an elastic elongation rate equal to less than 50%. A difference of the first and the second crimp number is in a range from 4 to 10. A compression resilience ratio of the fiber filling nonwoven is equal to or greater than 80%.

Abstract: The invention relates to a method of treatment comprising administering a long-acting mutant human fibroblast growth factor to a subject in need thereof. The said long-acting mutant human fibroblast growth factor is mPBG-CH2-N?H-mFGF21, wherein mFGF21 consists of SEQ ID NO:1, and the said new use consists of a method of treating non-alcoholic steatohepatitis.

Abstract: A method for preparing a long-chain branched polypropylene includes subjecting a T-reagent to a polymerization reaction with propylene in the presence of a catalyst composition. The catalyst composition includes an alkylaluminoxane and a metallocene-based catalyst. The metallocene-based catalyst contains a metal selected from the group consisting of titanium (Ti), zirconium (Zr), and hafnium (Hf). The T-reagent having an alkenyl silyl functional group is selected from the group consisting of 1,2-bis[dimethyl(vinyl)silyl]ethane, dimethyldivinylsilane, 7-octenyldimethyl(vinyl)silane, 7-octenyldimethyl(allyl)silane, 4-(but-3-enyl)phenyldimethyl(vinyl)silane, 4-(but-3-enyl)phenyldimethyl(allyl)silane, and combinations thereof.

Abstract: Provided herein are photopolymerizable monomers, optionally for use as reactive diluents in a high temperature lithography-based photopolymerization process, a method of producing polymers using said photopolymerizable monomers, the polymers thus produced, and orthodontic appliances comprising the polymers.

Abstract: Disclosed are a self-adaptive all-fiber laser ultrasonic measuring instrument and a measuring method thereof. The output light of a narrow-linewidth semiconductor fiber laser is split by a polarization controller and a polarization beam splitter to generate detection light and reference light. The detection light and visible light output by an indication laser are irradiated, through a wavelength division multiplexer and a biaxial scanning galvanometer, to a sample under test to generate ultrasonic vibration. The scattered light modulated by the ultrasonic vibration is converged and collected as signal light. The signal light and the reference light are respectively input into an interferometer from two ends of the interferometer in opposite propagation directions. The reference light demodulated by the interferometer generates a feedback control signal for adjusting the measurement performance of the interferometer.

Abstract: Systems and methods described herein relate to assessing the quality of electrocatalyst-loaded disk electrodes. In one embodiment, a system that assesses the quality of electrocatalyst-loaded disk electrodes receives one or more images of a disk electrode on which an electrocatalyst has been deposited to produce an electrocatalyst-loaded disk electrode. The system also processes the one or more images using a machine-learning-based model trained to generate a prediction of a Koutecky-Levich (K-L) quality assessment of the electrocatalyst-loaded disk electrode. The system also accepts or reject inclusion of the electrocatalyst-loaded disk electrode in an electrochemical experimentation process based, at least in part, on the prediction.

Abstract: A method comprises measuring, at a surface of a wellbore during drilling of the wellbore, at least one drilling operational parameter and determining at least one at-bit model parameter, at a drill bit used for drilling the wellbore, based on the at least one drilling operational parameter measured at the surface of the wellbore. The method comprises determining a drilling efficiency based on the at least one at-bit model parameter.

Abstract: A method for updating a state of charge based on power characteristics of an electrochemical model of a lithium-ion battery includes obtaining an initial state of charge of a battery and a current sequence with a constant amplitude; obtaining a port voltage of the battery at each moment within a preset time period based on the initial state information about the battery and electrochemical model simulation of the lithium-ion battery; obtaining a current amplitude-state of charge-port power curved surface based on the port powers; fitting the current amplitude-state of charge-port power curved surface to a plane equation; and obtaining a current amplitude corresponding to the port power and the state of charge by using the plane equation based on the port power and the state of charge, and updating the state of charge based on the current amplitude and the preset time period.

Abstract: The invention discloses an outlier diagnosis method for a series-connected lithium battery cells, the average voltage changes at the initial stage of discharge Vx and the average voltage changes at the end of charge Vy are detected and calculated for each cell, then an outlier index and z-score are calculated, and the z-score is used to screen the cell outliers that need pay attention.

Abstract: A smart speaker including a first light sensor, a second light sensor, a loudspeaker and a processor is provided. The first light sensor is configured to sense the first ambient light brightness value. The second light sensor is configured to sense the second ambient light brightness value. The loudspeaker is configured to emit a sound. The processor is electrically connected to the first light sensor, the second light sensor and the loudspeaker, and is configured to control a sound effect of the sound according to the first ambient light brightness value and the second ambient light brightness value.

Abstract: A window air conditioner includes a housing, an indoor heat exchanger, an outdoor heat exchanger, a compressor, a fan assembly, an electrical assembly, and a reactor. The indoor heat exchanger and the outdoor heat exchanger are arranged along a first direction. The electrical assembly is electrically connected to the fan assembly, and is adjacent to a side of the housing in a second direction perpendicular to the first direction. The electrical assembly is configured to distribute power to components in the window air conditioner, to control operation of the components in the window air conditioner, and to protect a circuit in the window air conditioner. The reactor is electrically connected to the electrical assembly, and is adjacent to another side of the housing in the second direction.