Abstract: The present disclosure provides antibodies to V-domain Ig-containing Suppressor of T cell Activation (VISTA) and compositions comprising such antibodies. Also provided are methods of using antibodies that specifically binds to VISTA to treat diseases, e.g., to treat cancer.

Abstract: The present invention relates to the production of steviol glycoside rebaudiosides D4, WB1 and WB2 and the production of rebaudioside M from Reb D4.

Abstract: The present disclosure includes an extender for a surgical stapler. An example extender includes a proximal end configured to removably couple to a surgical handle assembly, a distal end configured to removably coupled to a reloadable cartridge assembly, and an extender drive rod configured to transfer power from the surgical handle assembly to the reloadable cartridge assembly.

Abstract: Described herein is a composition comprising nucleic acid sequences encoding at least two amino acid sequences selected from the group consisting of SEQ ID NOs: 1 to 247. Also described herein is a composition comprising nucleic acid sequences encoding at least two amino acid sequences selected from the group consisting of SEQ ID NOs: 6936 to 6994. Also described herein is a composition comprising nucleic acid sequences encoding at least two amino acid sequences selected from the group consisting of SEQ ID NOs: 12271 to 12396. Also described herein is a composition comprising nucleic acid sequences encoding at least two amino acid sequences selected from the group consisting of SEQ ID NOs: 49712 to 49814.

Abstract: A component for a vehicle includes a skid plate configured to attach to an underbody of the vehicle, a plurality of cooling channels extending in a longitudinal direction between the skid plate and the underbody of the vehicle, and a structural reinforcement extending outward from the skid plate. The skid plate, the plurality of cooling channels, and the structural reinforcement are additively manufactured in a unitary construction.

Abstract: Enhancements to existing gaming controllers facilitating expedient response time and fine-tuned accuracy are described. The enhancements comprise the internal modification of the stock resistance force supplied by the analog stick centering spring mechanism. Through modification, the force of resistance supplied may be increased to over 200 grams of force, or down to 40 grams of force, while maintaining full function of the analog stick mechanism. A second primary enhancement replaces the stock triggers, conventionally equipped with progressive resistance sensors, to a momentary ‘snap-action’ two-way switch, minimizing trigger pull distance, and removing the analog nature of the trigger to achieve optimal performance.

Abstract: Systems and methods are disclosed herein for monitoring tire aging with respect to a motor vehicle and/or across vehicle fleets. A computing device (e.g., cloud server) is linked to vehicle-mounted data acquisition devices which provide signals corresponding to ambient temperature and contained air temperatures for respective tires. The computing device ascertains oxidative aging characteristics for the tires, based on at least the collected ambient temperature and respective contained air temperature, and respective rates of accumulation thereof with respect to time and/or distance traveled, and further ascertains the oxidative aging characteristics for each tire with respect to a fixed reference ambient temperature, and respective rates of accumulation thereof with respect to time and/or distance traveled. Selectively generated output signals correspond to monitored characteristics and respective rates of accumulation thereof for the respective tires.

Abstract: An electrolyser for carbon dioxide reduction, having an electrolytic cell, with a cathode gas diffusion electrode and an anode gas diffusion electrode, in which a first side of the cathode gas diffusion electrode adjoins a cathode gas chamber in a planar manner and likewise a first side of the anode gas diffusion electrode adjoins an anode gas chamber, and an electrolyte chamber common to both gas diffusion electrodes is provided, which extends from the cathode gas diffusion electrode to the anode gas diffusion electrode and is at least partially delimited by the two gas diffusion electrodes with their second sides facing away from the respectively associated gas chambers.

Abstract: A tape applicator apparatus is disclosed and includes a tape cutter mechanism and a (tape) puller mechanism. The tape cutter mechanism includes a first frame, a product tension mechanism coupled to the first frame, and a hot wire assembly coupled to the first frame. The hot wire assembly includes a first mount, a second mount, and a wire between the first mount and the second mount. The puller mechanism includes a puller frame, a grabber coupled to the puller frame, and a grab actuator coupled to the grabber. The grab actuator may activate a grab operation of the grabber. The puller mechanism includes a reach actuator coupled to the puller frame and the grabber. The tape applicator apparatus may be configured to receive a package between the tape cutter mechanism and the puller mechanism.

Abstract: A green tape composition includes at least one Li-garnet ceramic powder; at least one excess lithium source; at least one dispersant; at least one binder; and at least one plasticizer, such that a porosity of the green tape composition is <10 vol. %. A method includes dispersing at least one lithium garnet powder and at least one excess lithium source in a predetermined ratio in an organic solvent to form a garnet suspension; adding at least one dispersant, at least one binder, and at least one plasticizer to the garnet suspension; milling the garnet suspension; and de-airing under vacuum, such that a porosity of the green tape composition is <10 vol. %.

Abstract: A method for maintaining a physical asset based on recommendations generated by analyzing operational data and analyzing at least one model representing the physical asset, includes constructing, by a computing device, using a port-reduced reduced basis element approximation of a partial differential equation, at least one model. The computing device analyzes an error indicator associated with the at least one model to determine that the error indicator exceeds a tolerance level and increases a number of basis functions in the port-reduced reduced basis element approximation accordingly. The computing device receives first operational data associated with a region of the physical asset and updates at least one model. The computing device provides a recommendation for maintaining the physical asset.

Abstract: An apparatus for separating cell suspension material into centrate and concentrate, includes a single use structure (178, 240, 250) releasably positioned in a cavity in a solid wall rotatable centrifuge bowl (172). The bowl and portions of single use structure rotate about an axis (174). A stationary inlet feed tube (184), a centrate discharge tube (212) and a concentrate discharge tube (230) extend along the axis of the rotating single use structure. A centrate centripetal pump (208) is in fluid connection with the centrate discharge tube. A concentrate centripetal pump (216) is in fluid connection with the concentrate discharge tube. A controller (274) operates responsive to sensors (264, 270) in respective centrate and concentrate discharge lines (262, 268), to control flow rates of a concentrate pump (272) and a centrate pump (266) to produce output flows of cell concentrate and generally cell free centrate.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The invention relates to a system for manufacturing a plurality of integrated circuits, IC, mounted on a common support, the system comprising: an input station configured (adapted, arranged) to receive at least one common support; an output station configured (adapted, arranged) to receive at least one common support having a plurality of integrated circuits formed thereon; a plurality of processing modules each module being operable (configured, arranged, adapted) to perform at least one of the processing steps (e.g. deposition, patterning, etching) for forming an integrated circuit on the common support; a transfer means operable (configured, arranged, adapted) to transfer the at least one common support from the input station to the output station and to one or more of the processing modules therebetween; control means (e.g.

Abstract: An electroactive material for an electrochemical cell that cycles lithium ions is provided. The electroactive material includes a plurality of atomic layers and a plurality of cations disposed between the atomic layers. The plurality of atomic layers includes an atom selected from the group consisting of: silicon, germanium, boron, and combinations thereof. The plurality of cations is selected from the group consisting of: calcium, magnesium, zinc, copper, nickel, potassium, sodium, and combinations thereof. A ratio of the cations to atoms that define the atomic layer may be less than about 1:2.

Abstract: A method for forming an electronic device that includes solder bonding pins from a component to plated through holes of a board, the component being positioned on a first side of the board; and applying solder paste to openings of the plated through holes on a second side of the board opposite the first side of the board that the component is positioned on. The method can further include drawing the solder paste to the pins to provide a reworked solder bond bonding at least one of the pins to the plated through hole.

Abstract: A fluid injector system for delivering a multi-phase fluid injection to a patient and methods of fluid delivery is disclosed. Methods of creating and using a multi-aspect fluid path impedance model of the injector system are used. Modeling and adjustment of factors that affect impedance and prevent or reduce backflow, reduce the likelihood of fluid flow rate spikes and provide more accurate flow rates and mixing ratios of fluids may be repeated or happen essentially continuously during an injection. The adjustments may be determined before the injection or determined and/or adjusted during the injection. The determination may include sensor feedback commonly used in injectors such as pressure and position feedback as well as other sensors. In all cases, the user can be notified of adjustments through on-screen notices and/or through the recordation of the injection data by a control device of the injector at the conclusion of the injection.

Abstract: A road safety barrier installation system that uses a workstation and product support able to be guided by a truck along a road. The product supporter is adapted to receive a store of product such as ground penetrating anchors, posts and barrier strap. The workstation comprises at least one placement robot able robot able to receive and hold a said product, and position the so received and held product in location as part of the array.

Abstract: A method includes receiving image frames of an inventory. The method includes locating a control point used to determine a spatial search in the image frames and detecting, by a machine learning model, a plurality of storage units in the spatial search. Each storage unit is associated with a unit type from a plurality of unit types. The method includes calculating a storage unit count from a plurality of storage unit counts and for each unit type from the plurality of unit types from the plurality of storage units detected based on depth analysis. Each storage unit count includes a total number of storage units associated with each unit type. The method includes determining a restock status of each unit type based on the storage unit count for each unit type, and automatically generating a replenish request based on the restock status.

Abstract: An apparatus and coolant pump for use in a thermal management system includes a pump housing having an inlet for receiving coolant from the thermal management system and at least first and second outlets extending from the pump housing for directing coolant to at least a first and a second coolant loop. An impeller coupled to an electrical pump motor drives the coolant from the inlet to the first or the second outlet. A valve mounted between the impeller and the first and second outlets selectively directs the flow of coolant through the first or the second outlet. A temperature sensor installed on the pump housing inlet measures the temperature of the coolant entering the coolant pump.