Abstract: The present invention relates to a method of forming a crystal complex of CDK2/cyclin A and a cyclin binding groove peptide oligomer using a technique involving ligand exchange within the protein crystal. The invention further relates to novel crystal complexes of CDK2/cyclin A with various peptide oligomers, methods of identifying cyclin binding groove ligands, and methods of treating proliferative disorders.

Abstract: The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.

Abstract: The present invention provides methods for accurate and efficient detection of compositions that specifically modulate the interaction and/or activity of CIITA, RFXANK, RFXAP and RFX5 polypeptide factors. Further methods are provided for identifying compositions whose specific modulation of these transcription factors affects expression of a MHC class II promoter. The disclosed methods are configured in an assay format useful in moderate and high throughput screening applications.

Abstract: Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.

Abstract: A gas sensor arrangement comprises a first half-shell mateable with a second half-shell. The first half-shell has a detector receiving opening and radiation source receiving apertures. A gas measuring chamber is formed between the first half-shell and the second half-shell. The gas measuring chamber extends between the detector receiving opening and the radiation source receiving apertures. Concave mirrors are arranged around the radiation source receiving apertures. The concave mirrors are formed by inner surfaces of the first and second half-shells. Tubes extend from the concave mirrors to the detector receiving opening. The tubes are formed by the inner surfaces of the first and second half-shells. The inner surfaces are coated with a reflective material.

Abstract: The conveyor pan according to the present invention has a framework construction (1) having the bottom run (2) and an interchangeably constructed exchangeable tray (4) forming the top run (3), which can be lifted out, vertically supported on the framework (1). The framework construction (1) of the conveyor pan (50) has two roiled U-profiles forming the side walls of the conveyor pan, each of which has a vertically extending intermediate arm (11), an upper, outwards facing flange arm (12) and, lower outwards facing flange arm (13). The identically constructed but mirror imaged iron U-profiles (10), i.e.

Abstract: In one aspect, the invention includes an isolation region forming method comprising: a) forming an oxide layer over a substrate; b) forming a nitride layer over the oxide layer, the nitride layer and oxide layer having a pattern of openings extending therethrough to expose portions of the underlying substrate; c) etching the exposed portions of the underlying substrate to form openings extending into the substrate; d) after etching the exposed portions of the underlying substrate, removing portions of the nitride layer while leaving some of the nitride layer remaining over the substrate; and e) after removing portions of the nitride layer, forming oxide within the openings in the substrate, the oxide within the openings forming at least portions of isolation regions.

Abstract: A power output stage for capacitive loads includes: an energy storage inductance, having one end connected to a reference potential and an opposite end connected on the input side to a power supply connection and on the output side to a secondary energy storage capacitance; a primary energy storage capacitance is connected upstream of the energy storage inductance on the input side, and connected on the input side via a primary switching element with a reference potential, and a secondary switching element connected in series with the secondary energy storage capacitance (4), characterized in that the input of the power output stage is clocked by an additional switch.

Abstract: A method and system for deferring transmission of a data packet over a home network is disclosed, where the home network includes a host media access controller program and a media access controller. The method and system include transmitting a first transmit signal from the host media access controller program to the media access controller (MAC) to transmit a data packet, and asserting a transmit start signal from the MAC in response. The method and system further include receiving a carrier sense signal on the MAC indicating activity on a transmission medium, and delaying assertion of a final transmit signal when it is determined that both the transmit start signal and the carrier sense signal are active, thereby avoiding packet collisions.

Abstract: A process for forming the ball and socket joint with bellows seal (10), a bellows seal (10) and a ball and socket joint with bellows seal (10) is provided including a ball pivot pin (36, 38) with a connection piece (40). The sealing bellows is provided with an annular engagement surface (16) with a cavity (20). The connection piece with a sealing face is connected to the ball pivot pin. Lubricant (22) is disposed in the cavity prior to assembly of the ball and socket joint. The annular engagement surface (16) is provided in contact with the sealing face upon assembly to cause an amount of lubricant (22) to be squeezed out of the cavity (20).

Abstract: In a two-step roller finger cam follower, a slider arm for engaging a high-lift cam lobe is pivotally mounted to the body and can variably engage a latch pin slidably disposed in a latch pin channel. A second channel in the body opens onto the slider arm and contains a timing pin that rides on an eccentric surface of the slider arm to extend or retract the timing pin. A bore between the latch pin channel and the timing pin channel contains a ball controlled by the timing pin to lock the latch pin into an engaged or disengaged position. The cam lobe has an undercut region such that the latch pin is allowed to move between engaged and disengaged position only when the slider arm is in the undercut region of the cam lobe. The latch pin can move only when the timing pin permits.

Abstract: The present invention relates to a protienaceous compound or functionally active derivative or part thereof having a binding site for a group represented by formula (I) which is part of a group of toxins derived from various cyanobacteria, to a method for its production, to diagnostic kits and to an affinty matrix (e.g. for use in immunoaffinity columns, online detection and purifications devices) containing the proteinaceous compound as well as to methods for substantially decreasing the amount of a compound containing the group represented by formula (I) in fluids or for concentrating compounds, e.g. toxins, containing the group represented by formula (I) from fluids such as crude water samples, extracts of algae or other tissue samples, e.g. to determine toxin concentrations.

Abstract: The present invention relates to novel compounds of the formula (I) in which W, X, Y, Z, G, A, B, Q1, Q2 and D are each as defined in the disclosure, to a plurality of processes for their preparation and to their use as pesticides and herbicides.

Abstract: A micromechanical component including a chip which is mounted on a substrate and has an encapsulated chip area which is higher than its vicinity, as well as a mounting area provided in the vicinity of the encapsulated chip area. The chip being mounted on the substrate by a mounting arrangement which is connected to the mounting area, so that the encapsulated chip area faces the substrate and is positioned at a distance therefrom. The encapsulated chip area is surrounded by an underfill beneath the chip. A method for the manufacture of the micromechanical component is also provided.

Abstract: A halftone screen is modified to reduce harmonic artifacts. Artifacts are modeled from the screen in a frequency domain. Threshold values in the screen are modified to reduce amplitude of at least some of the modeled artifacts.

Abstract: The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.

Abstract: A dental polishing tip is adapted to be coupled to a dental drive apparatus. The apparatus rotates the tip, thereby polishing the teeth. The tip includes: (i) a post having a proximal end and an opposing distal end, the proximal end being adapted to be coupled to the dental drive apparatus; (ii) an electrostatically flocked polishing head. The electrostatic flocking material on the polishing head at least temporarily increases the retention of the polishing material on the polishing head, thereby deceasing splattering.

Abstract: A warewash machine arm includes a body formed of a single piece of sheet metal. Adjacent edge parts of the formed sheet metal mat be sealed, such as by a seam weld, an epoxy or another sealing technique.

Abstract: A pump having top and bottom pieces coupled together by a coupling device features a circumferential clamp that is a lightweight plastic clamp having clamping members, each with one or more strengthening members oriented along a longitudinal axis defined in relation to the top and bottom pieces. The clamping members may include two semi-circular clamping members, each with circumferentially spaced strengthening rib members oriented along the longitudinal axis of the pump housing.

Abstract: In order to provide a track-guided transport system, and in particular a suspended monorail system, comprising a track network incorporating at least one node at which at least two track sections of the track network adjoin one another and also comprising a plurality of vehicles travelling along the track network and each of which comprises a control unit wherein the control of the movements of these vehicles can be effected in a simple and reliable manner even when there are a large number of vehicles, it is proposed that at least one successor or the information that the vehicle does not have a successor and/or at least one forerunner or the information that the vehicle does not have a forerunner be associated with each vehicle, wherein the information relating to the successor or the forerunner is stored in the control unit of the vehicle and is updated when the vehicle passes a node of the track network.