Abstract: A controller of a data storage device includes: a host interface providing an interface to a host computer; a flash translation layer (FTL) translating a logical block address (LBA) to a physical block address (PBA) associated with an input/output (I/O) request; a flash interface providing an interface to flash media to access data stored on the flash media; and one or more deep neural network (DNN) modules for predicting an I/O access pattern of the host computer. The one or more DNN modules provide one or more prediction outputs to the FTL that are associated with one or more past I/O requests and a current I/O request received from the host computer, and the one or more prediction outputs include at least one predicted I/O request following the current I/O request. The FTL prefetches data stored in the flash media that is associated with the at least one predicted I/O request.

Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Abstract: Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde (also referred to herein as Compound (I)) and intermediates used in such processes. Compound (I) binds to hemoglobin and increases it oxygen affinity and hence can be useful for the treatment of diseases such as sickle cell disease.

Abstract: A distributed storage system can include a storage node (125, 130, 135). The storage node (125, 130, 135) can include a Solid State Drive (SSD) or other storage device that employs garbage collection (140, 145, 150, 155, 160, 165, 225, 230), a device garbage collection monitor (205), a garbage collection coordinator (210), an Input/Output (I/O) redirector (215), and an I/O resynchronizer (220). The device garbage collection monitor (205) can determine whether any storage devices (140, 145, 150, 155, 160, 165, 225, 230) need to perform garbage collection. The garbage collection coordinator (210) can schedule when the storage device (140, 145, 150, 155, 160, 165, 225, 230) can perform garbage collection. The I/O redirector (215) can redirect read requests (905) and write requests (1005) away from the storage device (140, 145, 150, 155, 160, 165, 225, 230) when it is performing garbage collection.

Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Abstract: Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde (also referred to herein as Compound (I)) and intermediates used in such processes. Compound (I) binds to hemoglobin and increases it oxygen affinity and hence can be useful for the treatment of diseases such as sickle cell disease.

Abstract: A method of managing a database, the method including determining whether a deterministic threshold has occurred, determining whether a random threshold has occurred, and initiating a maintenance process on the database when either the deterministic threshold or the random threshold has occurred.

Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Abstract: A Processing-In-Memory (PIM) model in which computations related to the POPCOUNT and logical bitwise operations are implemented within a memory module and not within a host Central Processing Unit (CPU). The in-memory executions thus eliminate the need to shift data from large bit vectors throughout the entire system. By off-loading the processing of these operations to the memory, the redundant data transfers over the memory-CPU interface are greatly reduced, thereby improving system performance and energy efficiency. A controller and a dedicated register in the logic die of the memory module operate to interface with the host and provide in-memory executions of popcounting and logical bitwise operations requested by the host. The PIM model of the present disclosure thus frees up the CPU for other tasks because many real-time analytics tasks can now be executed within a PIM-enabled memory itself. The memory module may be a Three Dimensional Stack (3DS) memory or any other semiconductor memory.

Abstract: Disclosed are a method and system for recovering a distributed system from a failure of a data storage unit. The distributed system includes a plurality of computer systems, each having a read-write computer and a data storage unit. Data is replicated from a particular data storage unit to other data storage units using publish-subscribe model. A read-write computer receives the replicated data, processes the data for any conflicts and stores it in the data storage unit. If a data storage unit fails, another data storage unit that has latest data corresponding to the failed data storage unit is determined and the latest data is replicated to other data storage units. Accordingly, the distributed system continues to have the data of the failed data storage unit. The failed data storage unit may be reconstructed using data from one of the other data storage units in the distributed system.

Abstract: Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde (also referred to herein as Compound (I)) and intermediates used in such processes. Compound (I) binds to hemoglobin and increases it oxygen affinity and hence can be useful for the treatment of diseases such as sickle cell disease.

Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.

Abstract: A computing system includes: a write buffer block configured to: receive a data in a write buffer entry for staging the data prior to transferring the data to a storage cell, determine a validity identification of the data for a buffer entry address of the write buffer entry, store the data based on the validity identification to the write buffer entry, and a memory computing block, coupled to the write buffer block, configured to read the data for accessing the write buffer block.

Abstract: A system and method for leveraging a native operating system (130) page cache (315) when using non-block system storage devices (120) is disclosed. A computer (105) may include a processor (110), memory (115), and a non-block system storage device (120). A file system (135) may be stored in memory (115) and running on the processor (110), which may include a page cache (315). A key-value file system (KVFS) (145) may reside between the file system (135) and the storage device (120) and may map received file system commands (310) to key-value system commands (330) that may be executed by the storage device (120). Results of the key-value system commands (330) may be returned to the file system (135), permitting the operating system (130) to cache data in the page cache (315).

Abstract: A request management subsystem is configured to establish service classes for clients that issue requests for a shared resource on a computer system. The subsystem also is configured to determine the state of the system with respect to bandwidth, current latency, frequency and voltage levels, among other characteristics. Further, the subsystem is configured to evaluate the requirements of each client with respect to latency sensitivity and required bandwidth, among other characteristics. Finally, the subsystem is configured to schedule access to shared resources, based on the priority class of each client, the demands of the application, and the state of the system. With this approach, the subsystem may enable all clients to perform optimally or, alternatively, may cause all clients to experience an equal reduction in performance.

Abstract: Disclosed is a technology for publishing subscriptions in a publish-subscribe system in accordance with subscription groups. The technology may include (i) determining a consumption characteristic by which each of multiple subscribers in a publish-subscribe system consumes a subscription published by a publisher; (ii) identifying the subscribers whose consumption characteristics satisfy a specified similarity criterion; (iii) defining multiple subscription groups, each of which includes subscriptions of those of the subscribers whose consumption characteristics satisfy the specified similarity criterion; (iv) storing the subscriptions in multiple logical partitions of a storage system where each of the logical partitions contains a separate non-overlapping subset of the subscriptions; and (v) transmitting the subscriptions to the subscribers in accordance with the subscription groups.

Abstract: A distributed storage system can include a storage node (125, 130, 135). The storage node (125, 130, 135) can include a Solid State Drive (SSD) or other storage device that employs garbage collection (140, 145, 150, 155, 160, 165, 225, 230), a device garbage collection monitor (205), a garbage collection coordinator (210), an Input/Output (I/O) redirector (215), and an I/O resynchronizer (220). The device garbage collection monitor (205) can determine whether any storage devices (140, 145, 150, 155, 160, 165, 225, 230) need to perform garbage collection. The garbage collection coordinator (210) can schedule when the storage device (140, 145, 150, 155, 160, 165, 225, 230) can perform garbage collection. The I/O redirector (215) can redirect read requests (905) and write requests (1005) away from the storage device (140, 145, 150, 155, 160, 165, 225, 230) when it is performing garbage collection.

Abstract: The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.

Abstract: Embodiments of the inventive concept include a volatile memory device including a memory cell array, the memory cell array including multiple rows and/or banks to store data. The memory device can include an address decoder coupled to the memory cell array. The memory device can include a control logic section coupled to the address decoder. The control logic section can include a defresh logic section configured to intentionally violate, by an activate command, a row precharge time (TRP) and/or a row active time (TRAS) for each of the plurality of rows to clean the data from the memory cell array. Memory data can be cleaned from the memory cell array responsive to the violations.

Abstract: A variable output power supply includes a power unit comprising a housing including an output port, one or more accessories disposed in the housing, and a controller disposed in the housing and in communication with the output port. The variable output power supply also includes a power cable. The controller is operable to modify operation of the output port in response, at least in part, to insertion of the power cable in the output port.