Abstract: An online system trains a constraint prediction machine-learning model using an action-based loss function. The action-based loss function computes a weighted sum of (1) an accuracy of the constraint prediction model in predicting whether a user's interaction complies with a set of constraints and (2) an action score representing a number of actions taken by users to determine whether the user's action complies with the set of constraints. The online system may apply this trained constraint prediction model to future interaction data received from third-party systems to predict whether user interactions with those third-party systems comply with the set of constraints.

Abstract: The present invention relates to functional taste-improving composition comprising at least one taste-modifying protein (TMP), e.g., a sweet protein (SP) and at least one micropatching (MP) agent; and to uses thereof in the food and beverage industry.

Abstract: A closed, automated and scalable stirred tank bioreactor platform, capable of sustaining high fold expansion of hPSCs is provided. hPSCs are expanded in a controlled bioreactor using perfused xeno-free media. Cell harvest and concentration are performed in closed steps. The hPSCs can be cryopreserved to generate a bank of cells or further processed as needed. Cryopreserved cells can be thawed into a 2D tissue culture platform or a 3D bioreactor to initiate a new expansion phase or be differentiated to the clinically relevant cell type. The expanded hPSCs express hPSC-specific markers, have a normal karyotype and the ability to differentiate to the cells of the three germ layers. This end-to-end platform allows large expansion of high quality hPSCs that can support the required cell demand for various clinical indications.

Abstract: One example method includes performing a data management transaction, such as a data read operation, a data write operation, or a data delete operation, generating transaction metadata relating to the data management transaction, transmitting the transaction metadata to a blockchain network, and receiving, from the blockchain network, confirmation that the transaction metadata has been stored in a distributed ledger associated with the blockchain network.

Abstract: Described herein are engineered anti-IL-2 antibodies with modified amino acid sequences. The engineered antibodies would confer modified receptor binding specificity to an IL-2-anti-IL2 antibody complex, inhibiting the binding of IL-2 to CD25. The engineered anti-IL-2 antibodies would facilitate expansion of subsets of effector immune cells and decrease undesirable effects caused by IL-2. Thus, the engineered anti-IL-2 antibodies would be useful in treating disease such as cancer and infection.

Abstract: The disclosure relates to devices and methods for the treatment of edema which devices use an intravascular edema pump with an anticoagulant. The invention provides devices and methods for treating edema that use an indwelling catheter to place an impeller in a blood vessel of a patient, near an outlet of a lymphatic duct. Operating the impeller creates a local depression in blood pressure, which promotes drainage of lymph from the lymphatic system. The catheter is also used to release an anticoagulant such as heparin to wash and lubricate the impeller. Specifically, the anticoagulant inhibits clotting, hemolysis, or thrombosis from occurring and interfering with smooth operation of the impeller.

Abstract: A data storage device including a non-volatile memory device including one or more non-volatile memory sets and one or more endurance groups. Each of the endurance groups includes at least one of the non-volatile memory sets. The data storage device includes a controller coupled to the non-volatile memory device. The controller is configured to receive a pending command message from a host interface, where the received pending command message includes a command configured to be executed by a first endurance group of the number of endurance groups. The controller is further configured to determine an assigned command slot for storing the command, where the assigned command slot is selected form one of a private command slot pool associated with the first endurance group or a shared command slot pool, fetch the command from the host device, and store the fetched command in the assigned command slot.

Abstract: The present invention relates to a modified MNEI protein comprising an amino acid sequence that has two or more amino acids deletions, insertions, replacements, or any combination thereof, from a reference MNEI protein, wherein the modified MNEI protein has at least one improved food-related property compared to the reference MNEI protein; and to uses thereof in the food industry.

Abstract: A composition comprising at least two different strains of isolated bacteriophages, each capable of infecting a bacteria of the species Klebsiella pneumoniae, wherein at least one of said at least two different strains of isolated bacteriophages has a genomic nucleic acid sequence at least 90% identical to one of the nucleic acid sequence as set forth in SEQ ID NOs: 1-30. Uses thereof are also disclosed.

Abstract: Provided herein are kits comprised of a first container including a solution of fibrinogen-containing component that includes fibrinogen at a concentration range of about 5 mg/ml to about 30 mg/ml, and having a total protein concentration range of about 15 mg/ml to about 40 mg/ml; and a second container that includes a solution of thrombin-containing component. Further provided are mixtures comprised of fibrinogen and thrombin, calcium ions, and albumin, the mixture being comprised of total protein in a range of about 2.5 mg/ml to about 30 mg/ml, fibrinogen in a range of about 50% to about 80% of total protein, and albumin in a range of more than 0.65 mg/ml to about 3 mg/ml. Further provided herein are methods for preventing or reducing tissue adhesion, and hydrogel materials made of fibrin.

Abstract: Systems and methods for session similarity identification include receiving historical sessions for one of a plurality of machines operating in a cloud-based system. The methods can include receiving and manage sessions from any number of machines in the cloud-based system. The system then receives monitored sessions for the machine or plurality of machines, and calculates a similarity between the received historical sessions and the received monitored sessions. After calculating the similarity, the system defines a risk score based on the similarity.

Abstract: Various systems and methods are provided for reducing pressure at an outflow of a duct such as the thoracic duct or the lymphatic duct. A catheter system can include a catheter shaft configured to be at least partially implantable within a patient's vein, a flexible membrane attached to the catheter shaft, the flexible membrane being a collapsible, tube-like member having a lumen extending therethrough, and a single selectively deployable restriction member formed over a portion of the flexible membrane at substantially a midpoint between a proximal end of the flexible membrane and a distal end of the flexible membrane, the restriction member being configured to control a size of the lumen so as to direct a controlled volume of fluid from an upstream side of the restriction member to a downstream side the restriction member.

Abstract: A method includes receiving, at a computing device, a transcription of an audio recording, where the transcription is divided into a plurality of text sections. The method additionally includes associating one or more tags with each text section of the plurality of text sections, where each associated tag is extracted from text of the transcription. The method also includes selecting a subset of the plurality of text sections based at least on the one or more tags associated with each text section of the plurality of text sections. The method further includes providing, for display on the computing device, a representation of the transcription and a scroller interface, where the scroller interface allows for navigation to each text section in the subset based on user navigation to a tag associated with the text section.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for audio-visual speech separation. A method includes: obtaining, for each frame in a stream of frames from a video in which faces of one or more speakers have been detected, a respective per-frame face embedding of the face of each speaker; processing, for each speaker, the per-frame face embeddings of the face of the speaker to generate visual features for the face of the speaker; obtaining a spectrogram of an audio soundtrack for the video; processing the spectrogram to generate an audio embedding for the audio soundtrack; combining the visual features for the one or more speakers and the audio embedding for the audio soundtrack to generate an audio-visual embedding for the video; determining a respective spectrogram mask for each of the one or more speakers; and determining a respective isolated speech spectrogram for each speaker.

Abstract: A semiconductor integrated circuit (IC) comprising a signal path combiner, comprising a plurality of input paths and an output path. The IC comprises a delay circuit having an input electrically connected to the output path, the delay circuit delaying an input signal by a variable delay time to output a delayed signal path. The IC may comprise a first storage circuit electrically connected to the output path and a second storage circuit electrically connected to the delayed signal path. The IC comprises a comparison circuit that compares outputs of the signal path combiner and the delayed signal, wherein the comparison circuit comprises a comparison output provided in a comparison data signal to at least one mitigation circuit.

Abstract: A method for training a neural network (NN), the method includes: receiving a training dataset including: (a) multiple pairs of: (i) a diffraction image indicative of X-ray photons diffracted from structures formed in a sample responsively to directing an incident X-ray beam at an angle relative to the sample, and (ii) a label, including: a first parameter indicative of at least a first property of the structures, and a second parameter indicative of at least a second property of the incident X-ray beam, and (b) multiple predefined outputs for the multiple pairs, respectively. The NN is trained to obtain the predefined outputs by: (i) applying the NN to at least a given pair of the pairs, and (ii) responsively to receiving from the NN an estimated output of the given pair, providing the NN with a given predefined output of the predefined outputs that corresponds to the given pair.

Abstract: The disclosure relates to devices and methods for the treatment of edema, which devices use a restrictor for flow compensation. Devices and methods of the invention further use a flow-restrictor in the circulatory system, upstream of an intravascular pump, to balance pressure changes induced by the pump and to compensate for downstream flow. The device may be provided as an indwelling, intravascular catheter with a mechanical pump such as an impeller and a selectively deployable restrictor such as an inflatable balloon. Congestive heart failure or edema is treated by \ operating the pump in an innominate vein and using the restrictor for flow compensation, to restrict the upstream flow and thus amplify or maintain pressure reduction at the lymphatic outlet.

Abstract: A multi-directional digital camera comprising: a light sensor capable of converting incoming light beams into an electrical signal output representing an imaged scene; one or more multi-mode optical path controlling elements, each having at least two operation modes including (a) a first operation mode in which the multi-mode optical path controlling element reflects the light beams directed thereon, and (b) a second operation mode in which the multi-mode optical path controlling element enables passage of the light beams directed thereon; a controller configured to selectively change the imaged scene by selectively changing an optical path of the light beams, wherein changing the optical path is made by changing the operation modes of one or more of the multi-mode optical path controlling elements.

Abstract: An input/output (I/O) block for a semiconductor integrated circuit (IC), which includes: at least one I/O buffer, configured to define at least one signal path in respect of a connection to a remote I/O block via a communication channel, each signal path causing a respective signal edge slope; and an I/O sensor, coupled to the at least one signal path and configured to generate an output signal indicative of one or both of: (a) a timing difference between the signal edge for a first signal path and the signal edge for a second signal path, and (b) an eye pattern parameter for one or more of the at least one signal path.

Abstract: Described herein are engineered anti-IL-2 antibodies with modified amino acid sequences. The engineered antibodies would confer modified receptor binding specificity to an IL-2-anti-IL2 antibody complex, inhibiting the binding of IL-2 to CD25. The engineered anti-IL-2 antibodies would facilitate expansion of subsets of effector immune cells and decrease undesirable effects caused by IL-2. Thus, the engineered anti-IL-2 antibodies would be useful in treating disease such as cancer and infection.