Abstract: The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with ?-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.

Abstract: The present invention relates to IRAKIMiD degraders, their liquid formulations, and methods of use thereof for treating cancer.

Abstract: Disclosed are various embodiments for analyzing searches of verbal media content associated with media content features. A relatively popular portion of a media content item is determined based at least in part on a dialogue of the relatively popular portion of the media content item being included in a plurality of dialogue search queries received from a plurality of client devices. The media content item is rendered via a client device, and a recommendation for an item is via the client device in response to the relatively popular portion of the media content item being rendered.

Abstract: An optical distribution and splice frame system includes rack(s), enclosure(s), cable management component(s), and/or cassette(s) that have features to allow for different cable management configurations not yet available in the market. A fiber optic cassette and enclosure are designed to enable flexibility in cable management configurations for the overall system.

Abstract: Embodiments of this present disclosure may include a handle disposed on an outer surface of a housing of electrical circuitry. The handle may provide access to at least a portion of the electrical circuitry. The handle may include a status indicator that emits light in response to a control signal from control circuitry. The status indicator may be disposed around the handle. The control circuitry may detect a state of the electrical protection circuitry. The control circuitry may also transmit the control signal to the status indicator based on the state. The control signal may control one or more properties of the light emitted by the status indicator, and thus indicate to an operator the state of the electrical circuitry.

Abstract: Methods include pumping a fracturing pad fluid into a subterranean formation under conditions of sufficient rate and pressure to create at least one fracture in the subterranean formation, the fracturing pad fluid including a carrier fluid and a plurality of bridging particles, the bridging particles forming a bridge in a fracture tip of a far field region of the formation. Methods further include pumping a first plurality of fibers into the subterranean formation to form a low permeability plug with the bridging particles, and pumping a proppant fluid comprising a plurality of proppant particles.

Abstract: Example implementations relate to metadata operations in a storage system. An example includes a machine-readable medium storing instructions that upon execution cause a processor to: receive a data stream to be stored in persistent storage of a deduplication storage system; store data units of the data stream in a container entity group object according to arrival time, where the data units of the container entity group object are referenced by a plurality of container indexes; generate a data index to list each container index that references at least one data unit included in the container entity group object; and in response to a determination that the total size of the container entity group object exceeds the threshold size, transfer the container entity group object from memory to the persistent storage.

Abstract: A system and method for providing progressive awards can include a computing device in communication with a memory. The computing device can generate outcomes for a wagering game using a bet amount. The outcome can include one or more indicia. The computing device can update a progressive value using the bet amount and determine if a progressive threshold is satisfied based on an accrued hand count. In response to the progressive threshold being satisfied, the computing device can provide an award based on the progressive value.

Abstract: The present invention relates to methods of treating solid cancers and hematological malignances using MDM2 degraders.

Abstract: Example implementations relate to metadata operations in a storage system. An example includes detecting, by a storage controller of a deduplication storage system, a housekeeping operation to perform updates to data of a set of container indexes of stored deduplicated data; in response to a detection of the housekeeping operation, the storage controller identifying, among the set of container indexes, a plurality of container indexes associated with a particular journal group, the particular journal group comprising a plurality of journals to store updates to data of the plurality of container indexes, respectively; and maintaining, by the storage controller, the particular journal group loaded in memory until all of the updates of the housekeeping operation to the plurality of container indexes have been stored in the respective journals of the particular journal group.

Abstract: The derivation unit determines the stability of a parasympathetic nerve activity of the sleeper for each environment temperature, and derives a correspondence relationship between the environment temperature and the stability of the parasympathetic nerve activity of the sleeper. An estimation unit estimates an appropriate value of the environment temperature suitable for the sleeper based on the correspondence relationship derived by the derivation unit.

Abstract: The present invention provides a clip system that is optimal for suture treatment of living tissue. The clip system includes a clip unit having a first arm and a second arm capable of opening and closing, a wire capable of opening and closing the clip, and a sheath through which the wire can be inserted. The clip unit includes a support portion that swingably supports the first arm and the second arm.

Abstract: Methods for treating a substrate are disclosed. The substrate is deoxidized and then immersed in an electrodepositable pretreatment composition comprising a lanthanide series element and/or a Group IIIB metal, an oxidizing agent, and a metal-complexing agent to deposit a coating from the electrodepositable pretreatment composition onto a surface of the substrate. Optionally, the electrodepositable pretreatment composition may comprise a surfactant. A coating from a spontaneously depositable pretreatment composition comprising a Group IIIB and/or Group IVB metal may be deposited on the substrate surface prior to electrodepositing a coating from the electrodepositable pretreatment composition. Following electrodeposition of the electrodepositable pretreatment composition, the substrate optionally may be contacted with a sealing composition comprising phosphate and a Group IIIB and/or IVB metal. Substrates treated according to the methods also are disclosed.

Abstract: An optical distribution and splice frame system includes rack(s), enclosure(s), cable management component(s), and/or cassette(s) that have features to allow for different cable management configurations not yet available in the market. A fiber optic cassette and enclosure are designed to enable flexibility in cable management configurations for the overall system.

Abstract: A method for preparing discontinuous zipper chain for use in apparel manufacturing includes: programming a teeth-securing machine to secure zipper teeth at specified intervals along an edge of each of a pair of zipper tapes; feeding the pair of zipper tapes into the teeth-securing machine so as to secure interlocking zipper teeth to the zipper tapes at the specified intervals, thereby forming a discontinuous zipper chain having successive toothed sections positioned along a length thereof and spaced apart from one another by gap sections without zipper teeth; and spooling or packaging the discontinuous zipper chain for use in apparel manufacturing.

Abstract: Gaming devices, and methods for operating them, are provided that may display an attract mode display that includes one or more bonus markers and a plurality of denomination markers. One of the denomination markers may be highlighted, and a bonus prize associated with a bonus marker and the currently highlighted denomination marker may be determined and displayed in a region of the display associated with that bonus marker. The display may be controlled to display a denomination transition in which the highlighted denomination marker reverts to a non-highlighted representation and the next denomination marker is highlighted. In conjunction therewith, a bonus transition may be displayed in which the bonus prize displayed in association with at least one bonus marker is changed to a bonus prize associated with both that bonus marker and the newly highlighted denomination marker. Such operations may be repeated one or more times, if desired.

Abstract: The present invention provides engineered terminal deoxynucleotidyl transferase (TdT) polypeptides useful in template-independent polynucleotide synthesis using a nucleoside triphosphate-3?-O-removable blocking group (NTP-3?-O-RBG), as well as compositions, methods of utilizing these engineered polypeptides, and polynucleotides encoding the engineered terminal deoxynucleotidyl transferases.

Abstract: A method for manufacturing a heat exchanger includes stacking a plurality of parting sheets, a plurality of lengthwise closure bars, and a plurality of widthwise closure bars to form a rectangular first heat exchanger section. The first heat exchanger section includes at least one widthwise passage extending between a pair of the widthwise closure bars and at least one lengthwise passage extending between a pair of the lengthwise closure bars. The method also includes brazing the rectangular first heat exchanger section together and cutting a first side and a second side of the rectangular first heat exchanger section to give the first heat exchanger section a tapered-trapezoid profile. The method further includes brazing an end of a second heat exchanger section to the first or second side of the first heat exchanger section.

Abstract: Examples may include storage of a small object representation in a deduplication system. Examples may store the small object representation of an object in the deduplication system based on a determination that the object is smaller than a threshold size. In examples, the small object representation may include a direct reference from a top-level data structure to small object metadata in a bottom-level data structure of the small object representation.