Abstract: Apparatus, consisting of a probe configured to be inserted into contact with a myocardium, and an electrode attached to the probe. A temperature sensor, incorporated in the probe, is configured to output a temperature signal. A pump irrigates the myocardium, via the probe, with an irrigation fluid at a controllable rate, and a radiofrequency (RF) signal generator applies RF power via the electrode to the myocardium, so as to ablate the myocardium. The apparatus also has processing circuitry that measures a temperature of the probe, based on the temperature signal, while the RF power is applied and, when the measured temperature exceeds a preset target temperature, iteratively reduces the RF power applied by the signal generator and concurrently iteratively varies a rate of irrigation of the irrigation fluid provided by the pump, until the measured temperature is reduced to the preset target temperature.

Abstract: A method for applying bipolar ablation pulses, the method includes positioning multiple electrodes of a catheter in contact with tissue of an organ. The tissue is ablated using the multiple electrodes in accordance with a predefined pattern including a periodic set of time slots. Each of the time slots defines (i) an electrode-pair (EP), (ii) a waveform of one or more bipolar ablation pulses (BAPs) applied to the tissue by the EP, and (iii) a duration of the time slot. The time slots are applied sequentially, and the pattern further includes at least one time slot that is empty.

Abstract: A method of ablation includes storing in a memory a pre-determined relation between lesion size and amount of ablative energy, for each of one or more selected temperatures. Using a processor, user input is received, that indicates a lesion size and a tissue temperature. Based on the relation, an amount of energy is determined, that matches the lesion size and the tissue temperature. An ablation probe is controlled to apply the amount of ablative energy that matches the selected lesion size.

Abstract: Method and apparatus for quantum simulation, based on a linear chain of ions. A gradient field is imposed to break the symmetry of the ion chain, and bichromatic driving fields are applied to bridge the energy gaps induced by the gradient field and thereby establish resonance couplings among the ions according to their relative positions in the gradient field. The combination of the gradient field and the bichromatic driving fields implement excitation hopping to simulate a variety of topologies according to higher¬dimensional Hamiltonians and boundary conditions, including ring, torus, Mobius strip configurations, as well as topologies with periodic boundary conditions. In particular synthetic gauge fields allow simulation of magnetic flux.

Abstract: Apparatus, consisting of a probe configured to be inserted into contact with a myocardium, and an electrode attached to the probe. A temperature sensor, incorporated in the probe, is configured to output a temperature signal. A pump irrigates the myocardium, via the probe, with an irrigation fluid at a controllable rate, and a radiofrequency (RF) signal generator applies RF power via the electrode to the myocardium, so as to ablate the myocardium. The apparatus also has processing circuitry that measures a temperature of the probe, based on the temperature signal, while the RF power is applied and, when the measured temperature exceeds a preset target temperature, iteratively reduces the RF power applied by the signal generator and concurrently iteratively varies a rate of irrigation of the irrigation fluid provided by the pump, until the measured temperature is reduced to the preset target temperature.

Abstract: Apparatus, consisting of a probe configured to be inserted into contact with a myocardium, and an electrode attached to the probe. A temperature sensor, incorporated in the probe, is configured to output a temperature signal. A pump irrigates the myocardium, via the probe, with an irrigation fluid at a controllable rate, and a radiofrequency (RF) signal generator applies RF power via the electrode to the myocardium, so as to ablate the myocardium. The apparatus also has processing circuitry that measures a temperature of the probe, based on the temperature signal, while the RF power is applied and, when the measured temperature exceeds a preset target temperature, iteratively reduces the RF power applied by the signal generator and concurrently iteratively varies a rate of irrigation of the irrigation fluid provided by the pump, until the measured temperature is reduced to the preset target temperature.

Abstract: The present invention is directed to a method for inducing skipping of exon 24 of the cystic fibrosis transmembrane conductance regulator (CFTR) pre-mRNA. Further, treating cystic fibrosis (CF) using a splicing modulator, such as an antisense oligonucleotide, capable of inducing the skipping of exon 24 of the cystic fibrosis transmembrane conductance regulator (CFTR) pre-mRNA. Also provided are a composition and a kit comprising the splicing modulator.

Abstract: A method includes, in a processor, receiving signals from (i) a first position sensor disposed on a shaft of a catheter, and (ii) a second position sensor disposed on a distal end of a sheath of the catheter. Based on the signals received from the first position sensor and the second position sensor, an event is detected in which an expandable distal-end assembly of the catheter is being withdrawn into the sheath while still at least partially expanded. A responsive action is initiated in response to detecting the event.

Abstract: A method includes generating an ablation programming language, which defines commands for (i) setting ablation protocol parameters and respective values, (ii) setting a configuration of an ablation system, (iii) applying automatic logic that relates the ablation protocol parameters and the values to the configuration of the ablation system, and (iv) generating one or more graphical user interfaces (GUIs) showing one or more of the parameters of the ablation protocol and the system configuration. The ablation programming language is provided for subsequent use with the ablation system.

Abstract: Apparatus, consisting of a probe configured to be inserted into contact with a myocardium, and an electrode attached to the probe. A temperature sensor, incorporated in the probe, is configured to output a temperature signal. A pump irrigates the myocardium, via the probe, with an irrigation fluid at a controllable rate, and a radiofrequency (RF) signal generator applies RF power via the electrode to the myocardium, so as to ablate the myocardium. The apparatus also has processing circuitry that measures a temperature of the probe, based on the temperature signal, while the RF power is applied and, when the measured temperature exceeds a preset target temperature, iteratively reduces the RF power applied by the signal generator and concurrently iteratively varies a rate of irrigation of the irrigation fluid provided by the pump, until the measured temperature is reduced to the preset target temperature.

Abstract: A method includes, in a processor, receiving signals from (i) a first position sensor disposed on a shaft of a catheter, and (ii) a second position sensor disposed on a distal end of a sheath of the catheter. Based on the signals received from the first position sensor and the second position sensor, an event is detected in which an expandable distal-end assembly of the catheter is being withdrawn into the sheath while still at least partially expanded. A responsive action is initiated in response to detecting the event.

Abstract: A method of body tissue ablation includes defining a target amount of ablation energy needed to create a specified lesion in tissue in a body of a patient. Contact is made between an ablation probe and the tissue. Using the ablation probe, an ablation signal is applied to the tissue, which delivers the target amount of ablation energy during a smallest time duration permitted within a defined maximum-power constraint.

Abstract: In one embodiment, an ablation system includes a probe to be inserted into a heart and including an electrode to apply radiofrequency (RF) power so as to ablate a myocardium, an RF signal generator, a tracking module to compute a relative location and orientation of the probe, and a processor to receive a signal from at least one user input device indicating an actuation of a serial ablation procedure including performing ablations at different locations of the myocardium, and control the serial ablation procedure so that for each ablation the processor is configured to check whether the relative location and orientation of the probe are steady, automatically compute an ablation duration, automatically control the RF signal generator to generate the RF power for the computed ablation duration, and render a user interface screen including a time indicator indicating a time remaining until an end of the ablation duration.

Abstract: The present invention relates to a playground interactive gaming system which integrates physical playground play with interactive computerized gaming, thus attracting children of all ages to enjoy healthy outdoor physical activity while playing a single-player or multi-player video game.

Abstract: The present invention provides methods for treating Cystic Fibrosis (CF) and methods for suppressing the inclusion of a cryptic exon between exon 22 and 23 as a result of the mutation 3849+10 Kb C-to-T comprising the step of administering a pharmaceutical composition comprising synthetic oligonucleotides complementary to a region of the CFTR comprising the 3849+10 Kb C-to-T mutation oligonucleotides and a composition comprising one or more CFTR modifiers.

Abstract: The present invention provides oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene, including compositions comprising the oligonucleotides, and uses thereof, such as for suppressing the inclusion of a cryptic exon between exon 22 and 23 as a result of the mutation 3849 +10 Kb C-to-T, optionally in combination with additional CF therapeutics.

Abstract: Methods, apparatuses, and computer program products implement embodiments of the present invention that include grouping a set of electrodes disposed at a distal end of a medical probe and configured to contact tissue in a body cavity into a plurality of groups of adjacent electrodes. A set of selectable widgets having a one-to-one correspondence with the groups are presented on a display, and in response to receiving an input indicating selection of a given widget, an ablation selection status of one or more of the electrodes in the group corresponding to the selected widget can be toggled.

Abstract: A method includes inserting into an organ a catheter having multiple electrodes, and placing the electrodes in contact with tissue for ablation. A selection from among the electrodes is received, including (i) first and second electrodes defining a first section of the catheter having a plurality of the electrodes, and (ii) third and fourth electrodes defining a second section of the catheter having at least two of the electrodes. Identifying whether the first and second sections jointly form a single contiguous ablation line or two disjoint ablation lines. A first set of ablation pulses is applied to the electrodes of the first and second sections, in case the first and second sections form the single contiguous ablation line, or a second different set of ablation pulses is applied to the electrodes of the first and second sections, in case the first and second sections form the two disjoint ablation lines.

Abstract: A method includes generating a sequence of multiple optical pulses, for transmission into an optical fiber (12) having an array of multiple equally spaced reflectors (14) embedded therein, the sequence having a pulse duration and a pulse repetition interval (PRI) that guarantee that reflections of any of the optical pulses from any of the reflectors do not overlap. The sequence of optical pulses is transmitted into the optical fiber. The reflections of the optical pulses from the reflectors are extracted from the optical fiber. One or more events affecting the optical fiber are identified by analyzing the reflections.

Abstract: An atomic vector magnetometer and magnetometric methods based on atomic clock transitions unaffected by magnetic field strength for increased quantum coherency time, resulting in improved sensitivity over conventional Zeeman-based atomic magnetometry, where coherency is restricted by sensitivity to magnetic fields. Instead of measuring magnetic field strength in the direction of the quantization axis, as in Zeeman magnetometry, magnetic field strength is measured substantially orthogonal to the quantization axis, via determining the angular displacement of the quantization axis by the magnetic signal field, which is detected by changes in atomic state populations as the quantization axis is rotated relative to the excitation polarization. In addition, the present invention measures magnetic fields instantaneously rather than via accumulated phase shift over time, as in Zeeman magnetometry, thereby providing measurement and spectral analysis of time-varying magnetic fields.