Abstract: The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.

Abstract: Molecularly imprinted smart polymers (MISPs) are provided herein, as well as novel monomers for preparing MISPs, and processes for preparing MISPs. The MISPs can be used applications such as, for example, detecting/absorbing or isolating biological and non-biological agents. The MISPs described herein comprise responsive monomeric units which undergo a physico-chemical change (e.g., a bond formation or cleavage) in response to an external change, such that the MISP selectively binds to a target molecule and releases a bound target molecule in response to the external change.

Abstract: The present invention relates to a method for preventing the simultaneous modification of the same database object in a shared database by more than one user during the database development stage comprising the steps of: (a) creating security roles for said users, wherein each of the security roles has a modification permission set for denying or granting at least one modification permission to at least one said database object; (b) assigning each of said security roles to each of said users; (c) providing means for said users to request said modification permission to said database object; (d) receiving said request from a first user for said modification permission to said at least one database object; (e) determining that said security roles of said users, excluding the security role of first user, are set to deny said modification permissions to said object; (f) updating said security role of said first user to grant said modification permission to said object; (g) allowing said first user to modify said

Abstract: A pump for generating fluid flow in an elastic tubular conduit. The pump comprises a plurality of electrically operated valves, each valve being positionable adjacent to the conduit. Each valve has a valve head configured to alternate from a first position in which the lumen of the conduit adjacent to the valve head is unobstructed and a second position in which the lumen of the conduit adjacent to the valve head is obstructed. The pump also comprises a driver configured to control the positions of the valve heads, so as to execute a predetermined temporo-spatial array of valve head positions.

Abstract: A pump for generating fluid flow in an elastic tubular conduit. The pump comprises a plurality of electrically operated valves, each valve being positionable adjacent to the conduit. Each valve has a valve head configured to alternate from a first position in which the lumen of the conduit adjacent to the valve head is unobstructed and a second position in which the lumen of the conduit adjacent to the valve head is obstructed. The pump also comprises a driver configured to control the positions of the valve heads, so as to execute a predetermined temporo-spatial array of valve head positions.

Abstract: The present invention is a miniature medication pump. With a small lightweight mechanism, operating on low energy consumption, the medication pump device is a highly reliable controlled portable device of drug infusion to patients. The proposed device is comprised of a piezoelectric actuator, operated by a programmable logic means, which applies force on a lever. The lever is situated between two unidirectional stoppers and transfers the force of the actuator onto the front stopper. The front stopper has a grip on the plunger stem and it therefore pushes it in the direction of the syringe and releases controlled amounts of medication to the body of the patient. The invention also include monitoring mechanisms which enable constant and accurate measurements of the amount of medication which is released from the device in actuality. The user of the pump is alerted about detected deviations from the designated flow of the medication.

Abstract: Disclosed is a shield for covering electrical outlets and switches, including their plates, during painting or other wall surface finishing process, such as plastering, priming, texturing, stucco coating, etc. The shield includes a shield encasement and a handle, which may be threadably coupled to an outer surface of the encasement. The shield may come in various sizes and shapes, based on the size and shape of the plates to be covered. The threadable handle allows the shield to be held in place with one hand, so that it covers the switch or outlet, including plate, while applying paint or other finish to the wall with the other hand, using any convenient technique such as spraying or brushing.

Abstract: A micro-pump that supplies medication from a reservoir to a patient through a flexible tube is disclosed. The pump, which is especially suitable but not confined to delivering insulin to diabetic patients, is small and light enough to be attached to the body using adhesive plaster or to be strapped to the body in any other manner. In the preferred embodiment the pump mechanism comprises a lead screw, a weak force rotating element, an actuator, and a high force holding element. The device also includes a processing circuitry for controlling and monitoring the drive mechanism, a force sensor to measure medication pressure which generates indicative signals to the processing circuitry, a sensor for tracking the position of the syringe plunger, and a remote control unit.

Abstract: An apparatus for mounting a pet shelter to a pet door panel in a sliding glass door assembly. The apparatus has both left and right side posts which sandwich a pet door panel. A retaining frame is attached to either or both posts and is capable of retaining the pet shelter. The retaining frame has cross members that allow the pet shelter to be attached in a folded down configuration and further has a shelter support element for holding the pet shelter in a folded up configuration. A hinge may be attached between the retaining frame and either post for allowing the pet shelter to be tilted out of the way when not in use.

Abstract: An apparatus for mounting a pet shelter to a pet door panel in a sliding glass door assembly. The apparatus has both left and right side posts which sandwich a pet door panel. A retaining frame is attached to either or both posts and is capable of retaining the pet shelter. The retaining frame has cross members that allow the pet shelter to be attached in a folded down configuration and further has a shelter support element for holding the pet shelter in a folded up configuration. A hinge may be attached between the retaining frame and either post for allowing the pet shelter to be tilted out of the way when not in use.

Abstract: An adapter for converting a foldable pet shelter into a self encased pet crate. The crate adapter has an end panel and a bottom panel, both of which may be joined together. The end panel is removably attachable to the foldable pet shelter along the back edge perimeter of the left side, right side, and top panels of the foldable pet shelter, while the bottom panel is removably attachable to the foldable pet shelter along the bottom edge perimeter of the left side, right side, and front side panels of the foldable pet shelter. Component lock elements positioned along various locations on the end and bottom panels of the adapter provide elements for removably securing the adapter to the foldable pet shelter, thereby converting the joined components into a self encased pet crate having a top panel, a right side panel, a left side panel, a front panel, a back panel, and a bottom panel.

Abstract: A splitterless system provides along a subscriber loop, full Ethernet wire speed data transmission between a date source and an Ethernet standard end device. The system includes a gateway modem device connected to a data source, and arranged in splitterless contact with a subscriber loop extending between a Punch Down Block (PDB), and an Ethernet standard end device; and a user modem device connected between the Ethernet standard end device and the subscriber loop so as to define with the gateway modem device a subscriber loop segment, wherein the gateway modem device and the user modem device are operative to communicate along the loop segment in different predetermined, first and second frequency spectra, for uplinking and downlinking, respectively, thus to facilitate therealong full Ethernet wire speed data transmission therealong.

Abstract: A process for using an illuminating box for facilitating the level installation of tiles. The illuminating box has a top and four sides which are opaque. The bottom is light transmitting and lies in a single plane so that when a portion of the bottom is placed on one tile and the box is allowed to overhang an adjacent tile, light will escape on any area which lies below the bottom plane of the illuminating box. The process includes the steps of laying at least two tiles on a substrate and turning on the light in the illuminating box. Next, the box is placed on one tile so that its bottom edges extend over an adjacent tile. Next, the resulting light pattern on top of the floor tiles is observed to illuminate any lack of flatness.

Abstract: A foldable pet shelter for attachment around a pet door against the interior surface of an exterior door of a house. The pet shelter has a top panel which is hinged to the interior surface of an exterior door above a pet door. A right side panel and a left side panel are hingedly held along the sides of the top panel and when the shelter is unfolded, the top panel, side panels and an end panel provide a shelter within a residence which permits a pet to enter the residence from the outdoors but retains the pet within the confines of the shelter. This provides a warm or cool place for the pet during inclement weather while still not permitting the pet to roam around the house.

Abstract: A device and method for giving proper shape to a bag for display purposes comprising an inflatable member which is placed inside the bag and then inflated to cause the bag move outwardly to its full and expanded size.

Abstract: A skylight leakage barrier for reducing the tendency of a skylight assembly to leak during heavy rainstorms. The skylight leakage barrier has a generally vertical top barrier which extends across the top edge of the skylight assembly. The top barrier has two downwardly depending side barriers and the top barrier and side barriers are separated from the skylight assembly by a distance of several inches. The result of the use of the leakage barrier is a substantial reduction in the tendency of the skylight assembly to leak during heavy rainstorms.

Abstract: A method for the biological control of pollen in plants, including the thinning of fruits, reducing seeds in citrus plants and reducing the incidence of shotberries in grapes, by applying an effective amount of activated or inactivated RNase or mixtures of these to the flowers of the plants.

Abstract: A device for giving proper shape to a bag (24) or the like for display purposes comprises an inflatable member (10) which is so designed and arranged to be placed inside the bag or the like to be displayed, and which when inside the bag is capable of then being inflated outwardly to cause the bag to move outwardly to its full and expanded size.