Patents by Inventor Orhun K. Muratoglu

Orhun K. Muratoglu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210228775
    Abstract: The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.
    Type: Application
    Filed: April 5, 2021
    Publication date: July 29, 2021
    Inventors: Ebru ORAL, Orhun K. MURATOGLU
  • Publication number: 20210178027
    Abstract: This present invention relates to drug eluting polymers, including novel biodegradable drug eluting polymers, which are added to the surface of a medical device to treat device associated complications and to deliver drug locally around the device. Methods of making polymers, for example, drug-eluting polymers, polymer compositions, and materials used therewith also are provided. The drug eluting polymers are obtained from the polymerization of macromonomers made of a connecting moiety, a biodegradable moiety and a cross-linkable moiety that are liquids at a temperature of 10° C. to 40° C.
    Type: Application
    Filed: February 3, 2017
    Publication date: June 17, 2021
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Ebru ORAL, Jeremy V. SUHARDI, Orhun K. MURATOGLU, Henrik MALCHAU, Harry E. RUBASH, Andrew A. FREIBERG
  • Patent number: 10981302
    Abstract: Methods of making oxidation and wear resistant polymeric materials using peroxide cross-linking and high temperature melting process are disclosed. A multiple step procedure for enabling the manufacturing of such material without size limitations is also disclosed.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: April 20, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Orhun K. Muratoglu, Ebru Oral
  • Patent number: 10967100
    Abstract: The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: April 6, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Ebru Oral, Orhun K. Muratoglu
  • Patent number: 10821632
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: November 3, 2020
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Patent number: 10696802
    Abstract: The invention provides creep resistant, lubricious and tough PVA-PAAm-hydrogels, creep resistant, lubricious, tough PVA-PAAm-hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the creep resistant, lubricious and tough PVA-PAAm-hydrogels, or the PVA-PAAm-hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked PVA-PAAm-hydrogels, and cross-linked PVA-PAAm-hydrogel-containing compositions also are disclosed herein.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: June 30, 2020
    Assignee: The General Hospital Corporation
    Inventors: Orhun K. Muratoglu, Hatice Bodugoz-Senturk
  • Publication number: 20190255744
    Abstract: Methods of making oxidation and wear resistant polymeric materials using peroxide cross-linking and high temperature melting process are disclosed. A multiple step procedure for enabling the manufacturing of such material without size limitations is also disclosed.
    Type: Application
    Filed: March 4, 2019
    Publication date: August 22, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Orhun K. MURATOGLU, Ebru ORAL
  • Publication number: 20190209331
    Abstract: A method of manufacturing at least one component of a joint prosthesis, the method comprising creating a first database representing an anatomy of an articulating bone of a joint of a subject; accessing a second database representing a geometry of a generic prosthetic component being sized to fit around an outer articulating surface of the articulating bone of the joint of the subject; creating a third database representing kinematic data of the subject's joint; merging the databases within a three-dimensional image-based medium. The generic prosthetic component is attached to the outer articulating surface of the articulating bone of the joint creating a prosthetic articulating surface that is moved through the kinematic data of the subject through a bearing template thereby modifying the bearing template to create a kinematically appropriate bearing surface; and manufacturing the component of the joint prosthesis to have a geometry corresponding to the kinematically appropriate bearing surface.
    Type: Application
    Filed: May 9, 2017
    Publication date: July 11, 2019
    Inventors: Kartik Mangudi Varadarajan, Orhun K. Muratoglu, Henrik Malchau
  • Publication number: 20190160207
    Abstract: The invention related to therapeutic polymeric materials and medical implants containing additives and/or analgesic agents. The invention also relates to methods of making therapeutic polymeric materials and medical implants containing additives and/or analgesic agents. Methods of spatially controlling additive concentrations and release as well as polymeric material morphology are also provided.
    Type: Application
    Filed: April 27, 2017
    Publication date: May 30, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Jeremy V. SUHARDI, Ebru ORAL, Orhun K. MURATOGLU, Hany BEDAIR
  • Publication number: 20190134273
    Abstract: The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 9, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Ebru ORAL, Orhun K. MURATOGLU
  • Patent number: 10220547
    Abstract: Methods of making oxidation and wear resistant polymeric materials using peroxide cross-linking and high temperature melting process are disclosed. A multiple step procedure for enabling the manufacturing of such material without size limitations is also disclosed.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: March 5, 2019
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Orhun K. Muratoglu, Ebru Oral
  • Patent number: 10213313
    Abstract: Femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants, e.g., hip replacement implants, and methods of using femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants are provided. Prosthetic femoral heads, mobile inserts, and acetabular components are provided that can alleviate soft tissue impingement, reduce implant wear, and/or reduce frictional torque. Modular junctions are provided that can minimize the incidence of loosening and micromotion that can occur at modular junctions of orthopedic implants.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: February 26, 2019
    Assignee: The General Hospital Corporation
    Inventors: Orhun K. Muratoglu, Kartik Mangudi Varadarajan, Henrik Malchau, Harry E. Rubash, Andrew A. Freiberg, Michael Patrick Duffy, Thomas Zumbrunn
  • Patent number: 10189961
    Abstract: The invention provides creep resistant, highly lubricious, tough and ionic hydrogels, creep resistant, lubricious, tough ionic hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the creep resistant, highly lubricious, tough and ionic hydrogels including ionic PVA-hydrogels, ionic PVA-PAAMPS-hydrogels, or the ionic hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled ionic hydrogels and making cross-linked ionic hydrogels and cross-linked ionic hydrogel-containing compositions also are disclosed herein.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: January 29, 2019
    Assignee: The General Hospital Corporation
    Inventors: Orhun K. Muratoglu, Hatice Bodugoz-Senturk
  • Publication number: 20180318468
    Abstract: Therapeutic polymeric materials, therapeutic polymeric materials containing medical implants and methods for making the same, and related materials are described. Methods of making medical implants containing additives antibiotics, therapeutic polymers, and materials used therewith also are described. Methods of spatially controlling additive/antibiotic concentrations, non-homogenous distribution of therapeutic agents in polymeric materials and therapeutic medical implants containing layered constructs of polymeric materials are provided. Therapeutic medical implants containing incorporated therapeutic agents in the polymeric materials, for example, antibiotics into polymeric total joint implants, are useful for delivery of the therapeutic agents into the surrounding mediums.
    Type: Application
    Filed: November 10, 2016
    Publication date: November 8, 2018
    Applicant: THE GERERAL HOSPITAL CORPORATION
    Inventors: Ebru ORAL, Jeremy V. SUHARDI, Orhun K. MURATOGLU, Henrik MALCHAU, Harry E. RUBASH, Andrew A. FREIBERG
  • Publication number: 20180291158
    Abstract: The invention provides creep resistant, lubricious and tough PVA-PAAm-hydrogels, creep resistant, lubricious, tough PVA-PAAm-hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the creep resistant, lubricious and tough PVA-PAAm-hydrogels, or the PVA-PAAm-hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked PVA-PAAm-hydrogels, and cross-linked PVA-PAAm-hydrogel-containing compositions also are disclosed herein.
    Type: Application
    Filed: March 28, 2018
    Publication date: October 11, 2018
    Inventors: Orhun K. Muratoglu, Hatice Bodugoz-Senturk
  • Publication number: 20180194042
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Application
    Filed: March 7, 2018
    Publication date: July 12, 2018
    Applicants: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Publication number: 20180161480
    Abstract: The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.
    Type: Application
    Filed: July 19, 2017
    Publication date: June 14, 2018
    Inventors: Ebru ORAL, Orhun K. Muratoglu
  • Patent number: 9968709
    Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: May 15, 2018
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
  • Patent number: 9962463
    Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: May 8, 2018
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Patent number: 9943993
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: April 17, 2018
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg