Patents by Inventor Orhun K. Muratoglu

Orhun K. Muratoglu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGHLY CRYSTALLINE POLYETHYLENE
    Publication number: 20140272383
    Abstract: The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Applicant: The General Hospital Corporation
    Inventors: Orhun K. Muratoglu, Ebru Oral
  • METHODS FOR MAKING OXIDATION RESISTANT POLYMERIC MATERIAL
    Publication number: 20140183794
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
    Type: Application
    Filed: March 10, 2014
    Publication date: July 3, 2014
    Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation
    Inventors: Orhun K. MURATOGLU, Stephen H. Spiegelberg
  • Methods for making oxidation resistant polymeric material
    Patent number: 8728379
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: May 20, 2014
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • FEMORAL HEADS, MOBILE INSERTS, ACETABULAR COMPONENTS, AND MODULAR JUNCTIONS FOR ORTHOPEDIC IMPLANTS AND METHODS OF USING FEMORAL HEADS, MOBILE INSERTS, ACETABULAR COMPONENTS, AND MODULAR JUNCTIONS FOR ORTHOPEDIC IMPLANTS
    Publication number: 20140128988
    Abstract: Femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants, e.g., hip replacement implants, and methods of using femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants are provided. Prosthetic femoral heads, mobile inserts, and acetabular components are provided that can alleviate soft tissue impingement, reduce implant wear, and/or reduce frictional torque. Modular junctions are provided that can minimize the incidence of loosening and micromotion that can occur at modular junctions of orthopedic implants.
    Type: Application
    Filed: September 27, 2013
    Publication date: May 8, 2014
    Inventors: Orhun K. Muratoglu, Kartik Mangudi Varadarajan, Henrik Malchau, Harry E. Rubash, Andrew A. Freiberg, Michael Patrick Duffy, Thomas Zumbrunn
  • METHODS FOR MAKING OXIDATION-RESISTANT CROSS-LINKED POLYMERIC MATERIALS
    Publication number: 20140097559
    Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
    Type: Application
    Filed: September 25, 2013
    Publication date: April 10, 2014
    Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation
    Inventors: Orhun K. MURATOGLU, Edward T. Kopesky, Ebru Oral
  • PVA-PAA Hydrogels
    Publication number: 20140058009
    Abstract: The invention provides fabricated PVA-hydrogels, PVA-hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the PVA-hydrogels, or the PVA-hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked PVA-hydrogels, and cross-linked PVA-hydrogel-containing compositions also are disclosed herein.
    Type: Application
    Filed: August 22, 2013
    Publication date: February 27, 2014
    Inventors: Jeeyoung Choi, Orhun K. Muratoglu
  • Methods for making oxidation-resistant cross-linked polymeric materials
    Patent number: 8569395
    Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: October 29, 2013
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
  • PVA-PAA hydrogels
    Patent number: 8541484
    Abstract: The invention provides fabricated PVA-hydrogels, PVA-hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the PVA-hydrogels, or the PVA-hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked PVA-hydrogels, and cross-linked PVA-hydrogel-containing compositions also are disclosed herein.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: September 24, 2013
    Assignee: The General Hospital Corporation
    Inventors: Jeeyoung Choi, Orhun K. Muratoglu
  • HIGHLY CRYSTALLINE CROSS-LINKED OXIDATION-RESISTANT POLYETHYLENE
    Publication number: 20130245773
    Abstract: The present invention relates to methods for making highly crystalline cross-linked polymeric material, for example, highly crystalline cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped highly crystalline cross-linked polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 19, 2013
    Applicant: The General Hospital Corporation
    Inventors: Orhun K. MURATOGLU, Ebru ORAL
  • Methods for making oxidation resistant polymeric material
    Patent number: 8530057
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: September 10, 2013
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • Oxidation resistant homogenized polymeric material
    Patent number: 8461225
    Abstract: The present invention relates to methods for making oxidation resistant homogenized polymeric materials and medical implants that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and annealing the antioxidant doped UHMWPE in a super critical fluid, and materials used therein.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: June 11, 2013
    Assignee: The General Hospital Corporation
    Inventors: Orhun K. Muratoglu, Ebru Oral
  • Highly crystalline cross-linked oxidation-resistant polyethylene
    Patent number: 8426486
    Abstract: The present invention relates to methods for making highly crystalline cross-linked polymeric material, for example, highly crystalline cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped highly crystalline cross-linked polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
    Type: Grant
    Filed: February 3, 2005
    Date of Patent: April 23, 2013
    Assignee: The General Hospital Corporation
    Inventors: Orhun K. Muratoglu, Ebru Oral
  • Highly crystalline polyethylene
    Patent number: 8425815
    Abstract: The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: April 23, 2013
    Assignee: The General Hospital Corporation
    Inventors: Orhun K. Muratoglu, Ebru Oral
  • Highly crystalline polyethylene
    Patent number: 8420000
    Abstract: The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: April 16, 2013
    Assignee: The General Hospital Corporation
    Inventors: Orhun K. Muratoglu, Ebru Oral
  • METHODS FOR MAKING OXIDATION RESISTANT POLYMERIC MATERIAL
    Publication number: 20130062817
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
    Type: Application
    Filed: September 7, 2012
    Publication date: March 14, 2013
    Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation
    Inventors: Orhun K. MURATOGLU, Stephen H. Spiegelberg
  • Methods and Devices for Knee Joint Replacement with Anterior Cruciate Ligament Substitution
    Publication number: 20130018477
    Abstract: Methods and devices are provided for knee joint replacement with anterior cruciate ligament (ACL) substitution. Generally, the methods and devices can allow a knee joint to be partially or totally replaced in conjunction with substitution of the knee joint's ACL. In one embodiment, a knee replacement prosthesis can include a medial or lateral femoral implant, a femoral intercondylar notch structure, a medial or lateral tibial insert, and an ACL-substitution member. The ACL-substitution member can be configured to engage with the femoral intercondylar notch structure during a full range of knee motion and/or during only early knee flexion.
    Type: Application
    Filed: July 12, 2012
    Publication date: January 17, 2013
    Applicant: The General Hospital Corporation D/B/A Massachusetts General Hospital
    Inventors: Orhun K. Muratoglu, Kartik Mangudi Varadarajan, Guoan Li, Harry E. Rubash, Thomas Zumbrunn
  • Methods for making oxidation resistant polymeric material
    Patent number: 8318065
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: November 27, 2012
    Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
  • METHODS FOR MAKING OXIDATION-RESISTANT CROSS-LINKED POLYMERIC MATERIALS
    Publication number: 20120292816
    Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
    Type: Application
    Filed: July 31, 2012
    Publication date: November 22, 2012
    Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation
    Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
  • Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices
    Patent number: 8263676
    Abstract: A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: September 11, 2012
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Edward W. Merrill, William H. Harris, Murali Jasty, Orhun K. Muratoglu, Charles R. Bragdon, Daniel O. O'Connor, Premnath Venugopalan
  • METHODS FOR MAKING OXIDATION RESISTANT POLYMERIC MATERIAL
    Publication number: 20120215321
    Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
    Type: Application
    Filed: April 23, 2012
    Publication date: August 23, 2012
    Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation dba Massachusetts General Hospital
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg