Patents by Inventor Orlin Petrov

Orlin Petrov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9675616
    Abstract: The present invention relates to substituted phenoxypyridine compounds of general formula (I); in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: June 13, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: William Johnston Scott, Orlin Petrov, Manfred Möwes, Ningshu Liu, Ulf Bömer
  • Patent number: 8314248
    Abstract: The present invention describes a novel process for preparing an epothilone derivative using substituted pyridines and methyltrioxorhenium as catalyst.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: November 20, 2012
    Assignee: Bayer Pharma AG
    Inventors: Johannes Platzek, Orlin Petrov, Stephan Prühs
  • Publication number: 20120077984
    Abstract: The present invention describes a novel process for preparing an epothilone derivative using substituted pyridines and methyltrioxorhenium as catalyst.
    Type: Application
    Filed: November 30, 2011
    Publication date: March 29, 2012
    Inventors: Johannes Platzek, Orlin Petrov, Stephan Prühs
  • Patent number: 8053426
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: November 8, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Patent number: 7951790
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: May 31, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Patent number: 7935827
    Abstract: The present invention relates to new optically active heteroaromatic ?-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: May 3, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Johannes Platzek, Ludwig Zorn, Bernd Buchmann, Werner Skuballa, Orlin Petrov
  • Publication number: 20110071165
    Abstract: Aza- and polyazanthranyl amides and their use as medicaments in the treatment of diseases caused by persistent angiogenesis are described, as well as the intermediates used in the preparation of the aza- and polyazanthranyl amides.
    Type: Application
    Filed: November 24, 2010
    Publication date: March 24, 2011
    Applicant: NOVARTIS AG
    Inventors: Dieter SEIDELMANN, Martin KRÜGER, Orlin PETROV, Andreas HUTH, Karl-Heinz THIERAUCH, Andreas MENRAD, Martin HABEREY
  • Patent number: 7902178
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: March 8, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Publication number: 20110009654
    Abstract: The present invention relates to 11?-fluoro-3-acetoxyestra-3,5-dien-17-one as a suitable intermediate in the preparation of 11-fluoro-substituted steroids and to the process for preparation thereof. For this purpose, 11?-hydroxyestra-4-ene-3,17-dione is reacted with 1 to 3 equivalents of n-nonafluorobutanesulfonyl fluoride and 3 to 5 equivalents of diazabicycloundecene (DBU) at ?40 to ?20° C. in an organic aprotic solvent and, after an aqueous workup, reacted with 5 to 10 equivalents of acetic anhydride and 0.01 to 1 equivalent of a strong acid. The desired product precipitates spontaneously out of the reaction solution and is obtained in a very high purity by filtration. The process is notable for the very high yield, avoidance of a chromatographic purification of the product, a reduced proportion of wastes and significantly increased process throughput. The process according to the invention is therefore especially suitable for preparing 11?-fluoro-3-acetoxyestra-3,5-dien-17-one on a large industrial scale.
    Type: Application
    Filed: October 18, 2008
    Publication date: January 13, 2011
    Inventors: Orlin Petrov, Matthias Schneider, Rolf Bohlmann, Stephan Vettel
  • Publication number: 20100248313
    Abstract: The present invention relates to new optically active heteroaromatic ?-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.
    Type: Application
    Filed: December 18, 2008
    Publication date: September 30, 2010
    Inventors: Johannes Platzek, Ludwig Zorn, Bernd Buchmann, Werner Skuballa, Orlin Petrov
  • Patent number: 7659364
    Abstract: The synthesis of N-methyl-homocysteines and their use are described.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: February 9, 2010
    Assignee: CIS Bio International
    Inventors: Marc Willuhn, Johannes Platzek, Eckhard Ottow, Orlin Petrov, Claudia Borm, Dirk Hinz, Gregor Mann, John Lister-James, David M. Wilson
  • Patent number: 7626035
    Abstract: The present invention relates to new optically active heteroaromatic ?-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: December 1, 2009
    Assignee: Bayer Schering Pharma AG
    Inventors: Johannes Platzek, Ludwig Zorn, Bernd Buchmann, Werner Skuballa, Orlin Petrov
  • Patent number: 7595418
    Abstract: This invention describes protected 5,7-dihydroxy-4,4-dimethyl-3-oxoheptanoic acid ester and 5,7-dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptanoic acid ester for the synthesis of epothilones and epothilone derivatives and process for the production of these esters.
    Type: Grant
    Filed: June 5, 2004
    Date of Patent: September 29, 2009
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Juergen Westermann, Johannes Platzek, Orlin Petrov
  • Patent number: 7538100
    Abstract: The invention relates to 17?-alkyl-17?-oxy-estra-1,3,5(10)-trienes that have an antiestrogenic action with general formula I. In addition, the invention also relates to 17-oxo-estra-1,3,5(10)-trienes as well as 17?-hydroxy-estra-1,3,5(10)-trienes as intermediate products in the production of the estratrienes according to the invention. The invention also relates to the use of 17?-alkyl-17?-oxy-estratrienes for the production of pharmaceutical agents as well as pharmaceutical preparations that contain at least one 17?-alkyl-17?-oxy-estratriene as well as at least one pharmaceutically compatible vehicle.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: May 26, 2009
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Rolf Bohlmann, Nikolaus Heinrich, Rolf Jautelat, Jorg Kroll, Orlin Petrov, Andreas Reichel, Jens Hoffmann, Rosemarie Lichtner
  • Publication number: 20080242866
    Abstract: The present invention relates to a novel method of preparing anthranilamides of formula I: in which R1, R2, R3, A, E, Q, X, and W are defined in the claims, to a novel intermediate compound, and to the use of said novel intermediate compound for the preparation of said anthranilamides of formula I.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 2, 2008
    Inventors: Norbert SCHMEES, Orlin Petrov
  • Publication number: 20080242868
    Abstract: The present invention describes a novel process for preparing an epothilone derivative using substituted pyridines and methyltrioxorhenium as catalyst.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 2, 2008
    Inventors: Johannes PLATZEK, Orlin Petrov, Stephan Pruhs
  • Patent number: 7417056
    Abstract: Compounds of general formula (IIa) or (IIb) and their use as pharmaceutical agents.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: August 26, 2008
    Assignee: Schering AG
    Inventors: Stefan Jaroch, Hartmut Rehwinkel, Heike Schaecke, Norbert Schmees, Werner Skuballa, Jan Huebner, Orlin Petrov, Matthias Schneider, Christian Dinter
  • Publication number: 20080200440
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Application
    Filed: November 15, 2007
    Publication date: August 21, 2008
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Publication number: 20080161580
    Abstract: The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.
    Type: Application
    Filed: March 6, 2008
    Publication date: July 3, 2008
    Inventors: Jurgen Westermann, Johannes Platzek, Orlin Petrov
  • Publication number: 20080108838
    Abstract: The invention relates to a new synthetic process for the production of key intermediates useful in the synthesis of epothilones or epothilone derivatives, to certain compounds used to produce these key intermediates and to a process to produce said compounds.
    Type: Application
    Filed: December 12, 2007
    Publication date: May 8, 2008
    Inventors: Johannes Platzek, Orlin Petrov, Marc Willuhn, Klaus Graske, Werner Skuballa