Abstract: A process for the production of 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones, especially 4-(4-pyridylmethyl)-1(2H)-phthalazinone, is described, which is characterized by the reaction of phthalidyl-3-triphenylphosphonium salt with 4-pyridine aldehyde in the presence of a basic adjuvant, subsequent reaction with hydrazine hydrate and subsequent acid treatment, whereby this process avoids the technical safety and environmental problems of the known processes.

Abstract: The invention relates to aza- and polyazanthranyl amides, to their use as medicaments for treating diseases caused by persistent angiogenesis and to their intermediate products for producing the aza- and polyazanthranyl amides.

Abstract: A process for the production of 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones, especially 4-(4-pyridylmethyl)-1(2H)-phthalazinone, is described, which is characterized by the reaction of phthalidyl-3-triphenylphosphonium salt with 4-pyridine aldehyde in the presence of a basic adjuvant, subsequent reaction with hydrazine hydrate and subsequent acid treatment, whereby this process avoids the technical safety and environmental problems of the known processes.

Abstract: The invention relates to 3,5-diamino-1,2,4-triazoles as kinase inhibitors, the production thereof and the use of the same as a medicament for treating cancer, for example solid tumours and leukaemia, auto-immune diseases such as psoriasis, alopecia and multiple sclerosis, alopecia induced by chemotherapeutic agents and mucositis, cardiovascular diseases such as stenoses, arterioscleroses, and restenoses, infectious diseases such as those caused by unicellular parasites such as trypanosome, toxoplasma or plasmodium, or by fungi, nephrological diseases such as glomerulonephritis, chronic neurodegenerative diseases such as Huntington's disease, amyotropic lateral sclerosis, Parkinson's disease, AIDS dementia and Alzheimer's disease, acute neurodegenerative diseases such as cerebral ischemia and neurotrauma, and viral infections such as cytomegalovirus infections, herpes, hepatitis B and C, and HIV diseases.

Abstract: Ortho-substituted anthranilic acid amides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described.

Abstract: Substituted anthranilamides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis as well as their intermediate products for the production of anthranilamides are described.

Abstract: This invention relates to a process for the production of 7&agr;-methyl steroids of general formula I, 1

Abstract: The invention relates to 17&agr;-alkyl-17&bgr;-oxy-estra-1,3,5(10)-trienes that have an antiestrogenic action with general formula I. In addition, the invention also relates to 17-oxo-estra-1,3,5(10)-trienes as well as 17&bgr;-hydroxy-estra-1,3,5(10)-trienes as intermediate products in the production of the estratrienes according to the invention. The invention also relates to the use of 17&agr;-alkyl-17&bgr;-oxy-estratrienes for the production of pharmaceutical agents as well as pharmaceutical preparations that contain at least one 17&agr;-alkyl-17&bgr;-oxy-estratriene as well as at least one pharmaceutically compatible vehicle.

Abstract: The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

Abstract: The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.

Abstract: The synthesis of N-methyl-homocysteines and their use are described.

Abstract: The invention relates to crystalline lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane, their production and the recovery of the salt-free gadolinium complex of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane from the latter without the use of ion exchangers.

Abstract: The invention relates to the process for mono- and 1,7-bis-N-.beta.-hydroxyalkylation of cyclene, the corresponding mono- and 1,7-bis-N-.beta.-hydroxyalkyl-1,4,7,10-tetraazacyclododecane-Li-salt complexes as intermediate products in the process and the use of the N-(6-hydroxy-2,3-dimethyl-1,3-dioxepan-5-yl)-1,4,7,10-tetraazacyclododecan e-LiCl complex for the production of gadobutrol [Gd ocmplex of N-(1-hydroxy-methyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecane].

Abstract: A process for the production of 1,4,7,10-tetraazacyclododecane (cyclene) and its derivatives on an industrial scale comprises cyclotetramerizing of benzylaziridine that is produced in situ.

Abstract: The invention relates to complex compound as well as their salts consisting of at least one metal ion and one complexing agent of general formula I ##STR1## in which Z.sup.1, Z.sup.2 and s have different meanings, as well as their use for the production of agents for radiation therapy and for NMR diagnosis and diagnostic radiology, especially for contrasting the hepatobiliary system. Further, the invention relates to a process for the production of these compounds and agents.

Abstract: The invention relates to a process for the production of C-substituted diethylenetriamines of general formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have different meanings.