Patents by Inventor Ortwin Ertl
Ortwin Ertl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11339415Abstract: A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula R1C(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula R2CH(OH)R3 is oxidized and wherein R1, R2 and R3 in the compounds have different meanings.Type: GrantFiled: June 25, 2019Date of Patent: May 24, 2022Assignee: ANNIKKI GMBHInventors: Ortwin Ertl, Nicole Staunig, Marta Sut, Bernd Mayer
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Patent number: 11254959Abstract: The present invention relates to a process for the conversion of D-glucose. The process according to the invention comprises a step a) in which part of the D-glucose is enzymatically oxidized to D-gluconic acid (lactone) and a portion of the D-glucose which is essentially equimolar thereto is reduced to D-sorbitol. In addition to D-glucose, D-fructose is also present in the reaction mixture of step a). The process comprises a further step b) in which D-sorbitol formed from the D-glucose in step a) is enzymatically oxidized to D-fructose.Type: GrantFiled: May 18, 2017Date of Patent: February 22, 2022Assignee: ANNIKKI GMBHInventors: Ortwin Ertl, Bernd Mayer, Nicole Staunig
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Publication number: 20200325511Abstract: The present invention relates to a process for the conversion of D-glucose. The process according to the invention comprises a step a) in which part of the D-glucose is enzymatically oxidized to D-gluconic acid (lactone) and a portion of the D-glucose which is essentially equimolar thereto is reduced to D-sorbitol. In addition to D-glucose, D-fructose is also present in the reaction mixture of step a). The process comprises a further step b) in which D-sorbitol formed from the D-glucose in step a) is enzymatically oxidized to D-fructose.Type: ApplicationFiled: May 18, 2017Publication date: October 15, 2020Inventors: Ortwin Ertl, Bernd Mayer, Nicole Staunig
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Publication number: 20200239918Abstract: The present invention provides a process for obtaining n+a oxidation and reduction products from a mixture of n sugars selected from the group consisting of C5 and C6 sugars, wherein n is at least 2 and a is at least 1, wherein at least two of the sugars in the mixture are present at a non-equimolar ratio to each other, wherein, in a first stage, at least one of the sugars which are present at a non-equimolar ratio to each other is oxidized enzymatically and, at the same time, at least one of the other sugars present at a non-equimolar ratio to each other is reduced enzymatically, and wherein, in the first stage, a portion of at least one of the sugars present at a non-equimolar ratio to each other is not converted, and which is characterized in that, in at least a second stage, at least a portion of the sugar not converted in the first stage is oxidized enzymatically by half and, respectively, is reduced enzymatically by the remaining half.Type: ApplicationFiled: April 14, 2020Publication date: July 30, 2020Inventors: Ortwin Ertl, Bernd Mayer, Alexander Dybov
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Publication number: 20190323051Abstract: A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula R1C(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula R2CH(OH)R3 is oxidized and wherein R1, R2 and R3 in the compounds have different meanings.Type: ApplicationFiled: June 25, 2019Publication date: October 24, 2019Inventors: Ortwin Ertl, Nicole Staunig, Marta Sut, Bernd Mayer
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Patent number: 10370691Abstract: A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula R1C(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula R2CH(OH)R3 is oxidized and wherein R1, R2 and R3 in the compounds have different meanings.Type: GrantFiled: April 18, 2017Date of Patent: August 6, 2019Assignee: ANNIKKI GMBHInventors: Ortwin Ertl, Nicole Staunig, Marta Sut, Bernd Mayer
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Patent number: 10253340Abstract: Disclosed is a method for the isomerization of glucose by reduction to sorbitol and subsequent oxidation to fructose, in which the redox cofactors NAD+/NADH and NADP+/NADPH are regenerated in a one-pot-reaction, wherein one of the two redox cofactors is obtained in the reduced form thereof and the other redox cofactor in the oxidized form thereof as a result of at least two additional enzymatically catalyzed redox reactions (product forming reactions) taking place in the same reaction batch, wherein a) in the regeneration reaction, which transfers the reduced cofactor back to its originally oxidized form, oxygen or a compound of the general formula R1C(O)COOH is reduced, and b) in the regeneration reaction, which transfers the oxidized cofactor back to its originally reduced form, a compound of the general formula R2CH(OH)R3 is oxidized, wherein R1, R2 and R3 have different meanings in the compounds, characterized in that a mixture of glucose and fructose is used as a starting material.Type: GrantFiled: March 25, 2014Date of Patent: April 9, 2019Assignee: ANNIKKI GMBHInventor: Ortwin Ertl
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Patent number: 10113192Abstract: A method for the enzymatic production of D-fructose from D-glucose in a one-pot synthesis, wherein D-glucose is oxidized enzymatically to D-glucosone and D-glucosone is reduced enzymatically to D-fructose and the use of the D-fructose produced in this way for the production of furan derivatives.Type: GrantFiled: February 5, 2014Date of Patent: October 30, 2018Assignee: ANNIKKI GMBHInventors: Ortwin Ertl, Marta Sut, Martina Brandner
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Publication number: 20180230503Abstract: A process for the production of carbohydrate cleavage products, characterized by a combination of the measures that a lignocellulosic material is treated with an aqueous solution containing an alcohol, in particular a C1-4-alcohol or a phenol, and having a pH-value of between 11.0 and 14.0 in order to cleave lignocellulose and separate cleavage products from the material, whereby a material enriched with cellulose and hemicellulose is obtained, and the obtained material enriched with cellulose and hemicellulose is treated with at least one carbohydrate-cleaving enzyme in order to obtain the carbohydrate cleavage products.Type: ApplicationFiled: April 11, 2018Publication date: August 16, 2018Applicant: ANNIKKI GMBHInventors: Karin FACKLER, Kurt MESSNER, Chularat KRONGTAEW, Ortwin ERTL
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Publication number: 20180216142Abstract: The present invention provides a process for obtaining n+a oxidation and reduction products from a mixture of n sugars selected from the group consisting of C5 and C6 sugars, wherein n is at least 2 and a is at least 1, wherein at least two of the sugars in the mixture are present at a non-equimolar ratio to each other, wherein, in a first stage, at least one of the sugars which are present at a non-equimolar ratio to each other is oxidized enzymatically and, at the same time, at least one of the other sugars present at a non-equimolar ratio to each other is reduced enzymatically, and wherein, in the first stage, a portion of at least one of the sugars present at a non-equimolar ratio to each other is not converted, and which is characterized in that, in at least a second stage, at least a portion of the sugar not converted in the first stage is oxidized enzymatically by half and, respectively, is reduced enzymatically by the remaining half.Type: ApplicationFiled: July 20, 2016Publication date: August 2, 2018Inventors: Ortwin Ertl, Bernd Mayer, Alexander Dybov
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Patent number: 9970038Abstract: A process for the production of carbohydrate cleavage products, characterized by a combination of the measures that a lignocellulosic material is treated with an aqueous solution containing an alcohol, in particular a C1-4-alcohol or a phenol, and having a pH-value of between 11.0 and 14.0 in order to cleave lignocellulose and separate cleavage products from the material, whereby a material enriched with cellulose and hemicellulose is obtained, and the obtained material enriched with cellulose and hemicellulose is treated with at least one carbohydrate-cleaving enzyme in order to obtain the carbohydrate cleavage products.Type: GrantFiled: April 30, 2010Date of Patent: May 15, 2018Assignee: ANNIKKI GMBHInventors: Karin Fackler, Kurt Messner, Chularat Krongtaew, Ortwin Ertl
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Patent number: 9902981Abstract: A process for the production of furan derivatives from D-glucose, wherein A) D-glucose is converted into D-fructose in an enzymatic process, wherein redox cofactors are used and regenerated, whereby, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch, one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, whereby D-glucose is converted into D-fructose, involving two or more oxidoreductases, and B) D-fructose is converted into furan derivatives, and the use of furan derivatives produced in this manner.Type: GrantFiled: February 6, 2013Date of Patent: February 27, 2018Assignee: ANNIKKI GMBHInventors: Ortwin Ertl, Nicole Staunig, Marta Sut, Bernd Mayer, Marko Mihovilovic, Michael Schön, Johanna Hölbling
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Publication number: 20170218417Abstract: A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula R1C(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula R2CH(OH)R3 is oxidized and wherein R1, R2 and R3 in the compounds have different meanings.Type: ApplicationFiled: April 18, 2017Publication date: August 3, 2017Inventors: Ortwin Ertl, Nicole Staunig, Marta Sut, Bernd Mayer
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Patent number: 9644227Abstract: A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula R1C(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula R2CH(OH)R3 is oxidized and wherein R1, R2 and R3 in the compounds have different meanings.Type: GrantFiled: February 6, 2013Date of Patent: May 9, 2017Assignee: ANNIKKI GMBHInventors: Ortwin Ertl, Nicole Staunig, Marta Sut, Bernd Mayer
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Publication number: 20170073365Abstract: A method for the preparation of lignin from lignocellulosic material by pulping with alcohol, in particular with a C1-4 alcohol, water and a base, in particular NaOH, at a temperature below 100° C., in particular from 40° C. to 90° C., in particular from 50° C. to 70° C., characterized in that 3 to 12 parts of base, in particular 4 to 10 parts of base, in particular preferable 5 to 8 parts of base, are used per 100 parts of the dry lignocellulosic material to be pulped.Type: ApplicationFiled: November 4, 2016Publication date: March 16, 2017Inventors: Karin Fackler, Thomas Ters, Ortwin Ertl, Kurt Messner
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Patent number: 9487549Abstract: A method for the preparation of lignin from lignocellulosic material by pulping with alcohol, in particular with a C1-4 alcohol, water and a base, in particular NaOH, at a temperature below 100° C., in particular from 40° C. to 90° C., in particular from 50° C. to 70° C., characterized in that 3 to 12 parts of base, in particular 4 to 10 parts of base, in particular preferable 5 to 8 parts of base, are used per 100 parts of the dry lignocellulosic material to be pulped.Type: GrantFiled: September 1, 2011Date of Patent: November 8, 2016Assignee: Annikki GmbHInventors: Karin Fackler, Thomas Ters, Ortwin Ertl, Kurt Messner
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Publication number: 20160053289Abstract: Disclosed is a method for the isomerisation of glucose by reduction to sorbitol and subsequent oxidation to fructose, in which the redox cofactors NAD+/NADH and NADP+/NADPH are regenerated in a one-pot-reaction, wherein one of the two redox cofactors is obtained in the reduced form thereof and the other redox cofactor in the oxidised form thereof as a result of at least two additional enzymatically catalysed redox reactions (product forming reactions) taking place in the same reaction batch, wherein a) in the regeneration reaction, which transfers the reduced cofactor back to its originally oxidised form, oxygen or a compound of the general formula R1C(O)COOH is reduced, and b) in the regeneration reaction, which transfers the oxidised cofactor back to its originally reduced form, a compound of the general formula R2CH(OH)R3 is oxidised, wherein R1, R2 and R3 have different meanings in the compounds, characterised in that a mixture of glucose and fructose is used as a starting material.Type: ApplicationFiled: March 25, 2014Publication date: February 25, 2016Inventor: Ortwin Ertl
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Publication number: 20150353978Abstract: A method for the enzymatic production of D-fructose from D-glucose in a one-pot synthesis, wherein D-glucose is oxidized enzymatically to D-glucosone and D-glucosone is reduced enzymatically to D-fructose and the use of the D-fructose produced in this way for the production of furan derivatives.Type: ApplicationFiled: February 5, 2014Publication date: December 10, 2015Applicant: ANNIKKI GMBHInventors: Ortwin Ertl, Marta Sut, Martina Brandner
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Patent number: 9206292Abstract: A method for producing lignin derivatives from technical lignins by treatment with proteolytic enzymes (proteases), characterized in that the proteolytic treatment of the technical lignins significantly reduces the molar mass thereof.Type: GrantFiled: March 2, 2012Date of Patent: December 8, 2015Assignee: ANNIKKI GMBHInventors: Ewald Srebotnik, Thomas Ters, Karin Fackler, Kurt Messner, Ortwin Ertl
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Patent number: 9051257Abstract: A method of obtaining an aqueous solution of an alkali acetate from lignocellulose, wherein lignocellulose is treated with a first aqueous extraction solution having a pH value in the range of 12 to 14 and a content of a C1-4 alcohol, in particular ethanol or isopropanol, in the range of 40% to 90%, in particular of from 75% to 85%, whereby a first aqueous solution of an alkali acetate is obtained, and wherein said first solution of an alkali acetate is used to treat additional lignocellulose in order to enrich additional acetate in said first solution.Type: GrantFiled: September 5, 2012Date of Patent: June 9, 2015Assignee: ANNIKKI GMBHInventors: Thomas Ters, Karin Fackler, Kurt Messner, Ortwin Ertl