Patents by Inventor Osamu Matsushita
Osamu Matsushita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11829104Abstract: A toner comprising a toner particle comprising a binder resin and a crystalline resin, wherein the binder resin comprises an amorphous resin, when the toner is measured with a temperature-modulated differential scanning calorimeter, at least one endothermic peak derived from the crystalline resin is present in a temperature range from 55.0° C. to 95.0° C. in a total heat flow; and a ratio of an endothermic quantity of the endothermic peak in a reversing heat flow to an endothermic quantity of the endothermic peak in the total heat flow is 50.0% or more, a glass transition temperature Tg1st obtained in the reversing heat flow in a first temperature rise and a glass transition temperature Tg2nd obtained in a reversing heat flow in a second temperature rise satisfy Tg1st?Tg2nd?7.0° C.Type: GrantFiled: April 27, 2021Date of Patent: November 28, 2023Assignee: CANON KABUSHIKI KAISHAInventors: Takuya Mizuguchi, Yoshitaka Suzumura, Hiroyuki Tomono, Osamu Matsushita, Shotaro Nomura
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Patent number: 11624060Abstract: The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.Type: GrantFiled: February 9, 2018Date of Patent: April 11, 2023Assignees: The Board of Trustees of the University of Arkansas, The Kitasato InstituteInventors: Joshua Sakon, Jeffrey Roeser, Ryan Bauer, Katarzyna Janowska, Keisuke Tanaka, Osamu Matsushita, Kentaro Uchida
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Publication number: 20220257715Abstract: The present invention provides collagen-binding agents that can be used to treat wounds, ischemic heart disease, and other conditions. The collagen-binding agents comprise a therapeutic agent, a protease cleavage site, and a collagen-binding domain. The present invention further provides pharmaceutical compositions and biomedical devices comprising the disclosed collagen-binding agents, as well as methods for treating a condition using the collagen-binding agents.Type: ApplicationFiled: February 18, 2022Publication date: August 18, 2022Inventors: Joshua Sakon, Robert Beitle, Hazim Aljewari, Osamu Matsushita, Stephanie Beitle
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Patent number: 11360426Abstract: An electrophotographic apparatus comprising an electrophotographic photosensitive member, a charging device and a developing device, wherein the charging device comprises a conductive member arranged to be capable of contacting the electrophotographic photosensitive member, a conductive layer of the conductive member comprises a matrix domain structure, at least a part of the domains Dt is exposed at the conductive member outer surface, the matrix has a volume resistivity R1 of larger than 1.00×1012 ?·cm, the domains Dt has a volume resistivity of smaller than R1, the developing device comprises the toner, domains Dc formed of the crystalline material exist in a cross section of the toner, distances between adjacent wall surfaces of the domains Dc is from 30 to 1,100 nm, and a weight-average particle diameter D4 of the toner and distances Dms between adjacent wall surfaces between the domains Dt satisfies D4?Dms.Type: GrantFiled: October 15, 2020Date of Patent: June 14, 2022Assignee: CANON KABUSHIKI KAISHAInventors: Yoshitaka Suzumura, Hiroyuki Tomono, Takuya Mizuguchi, Osamu Matsushita, Shunsuke Matsushita, Masahiro Kurachi, Kazuhiro Yamauchi
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Patent number: 11360405Abstract: An electrophotographic apparatus comprising an electrophotographic photosensitive member, a charging device and a developing device, wherein the charging device comprises a conductive member arranged to be capable of contacting the electrophotographic photosensitive member, the conductive layer at the outer surface of the conductive member comprises a matrix and a plurality of domains dispersed in the matrix, at least some of the domains are exposed at the outer surface of the conductive member, the matrix has a volume resistivity R1 of larger than 1.00×1012 ?·cm, the volume resistivity R1 of the matrix is 1.0×105 times or more a volume resistivity R2 of the domains, the developing device comprises the toner comprising a toner particle and a silica fine particle, and a coverage ratio of the toner surface with the silica fine particles is from 62.0% by area to 100.0% by area as determined by X-ray photoelectron spectroscopy.Type: GrantFiled: October 15, 2020Date of Patent: June 14, 2022Assignee: CANON KABUSHIKI KAISHAInventors: Hiroyuki Tomono, Yoshitaka Suzumura, Takuya Mizuguchi, Osamu Matsushita, Masahiro Kurachi, Kazuhiro Yamauchi, Issei Imamura
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Patent number: 11279922Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.Type: GrantFiled: February 22, 2019Date of Patent: March 22, 2022Assignees: The Board of Trustees of the University of Arkansas, The Kitasato Institute, Montefiore Medical Center, National University Corporation Kagawa UniversityInventors: Tulasi Ponnapakkam, Sagaya Theresa Leena Philominathan, Joshua Sakon, Ranjitha Katikaneni, Takaki Koide, Osamu Matsushita, Robert C. Gensure, Nozomu Nishi
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Publication number: 20210356878Abstract: A toner comprising a toner particle comprising a binder resin and a crystalline resin, wherein the binder resin comprises an amorphous resin, when the toner is measured with a temperature-modulated differential scanning calorimeter, at least one endothermic peak derived from the crystalline resin is present in a temperature range from 55.0° C. to 95.0° C. in a total heat flow; and a ratio of an endothermic quantity of the endothermic peak in a reversing heat flow to an endothermic quantity of the endothermic peak in the total heat flow is 50.0% or more, a glass transition temperature Tg1st obtained in the reversing heat flow in a first temperature rise and a glass transition temperature Tg2nd obtained in a reversing heat flow in a second temperature rise satisfy Tg1st?Tg2nd?7.0° C.Type: ApplicationFiled: April 27, 2021Publication date: November 18, 2021Inventors: Takuya Mizuguchi, Yoshitaka Suzumura, Hiroyuki Tomono, Osamu Matsushita, Shotaro Nomura
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Patent number: 11001820Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.Type: GrantFiled: January 17, 2017Date of Patent: May 11, 2021Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, MONTEFIORE MEDICAL CENTERInventors: Tulasi Ponnapakkam, Sagaya Theresa Leena Philominathan, Joshua Sakon, Ranjitha Katikaneni, Takaki Koide, Osamu Matsushita, Robert C. Gensure, Nozomu Nishi
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Publication number: 20210116829Abstract: An electrophotographic apparatus comprising an electrophotographic photosensitive member, a charging device and a developing device, wherein the charging device comprises a conductive member arranged to be capable of contacting the electrophotographic photosensitive member, the conductive layer at the outer surface of the conductive member comprises a matrix and a plurality of domains dispersed in the matrix, at least some of the domains are exposed at the outer surface of the conductive member, the matrix has a volume resistivity R1 of larger than 1.00×1012 ?·cm, the volume resistivity R1 of the matrix is 1.0×105 times or more a volume resistivity R2 of the domains, the developing device comprises the toner comprising a toner particle and a silica fine particle, and a coverage ratio of the toner surface with the silica fine particles is from 62.0% by area to 100.0% by area as determined by X-ray photoelectron spectroscopy.Type: ApplicationFiled: October 15, 2020Publication date: April 22, 2021Inventors: Hiroyuki Tomono, Yoshitaka Suzumura, Takuya Mizuguchi, Osamu Matsushita, Masahiro Kurachi, Kazuhiro Yamauchi, Issei Imamura
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Publication number: 20210116860Abstract: An electrophotographic apparatus comprising an electrophotographic photosensitive member, a charging device and a developing device, wherein the charging device comprises a conductive member arranged to be capable of contacting the electrophotographic photosensitive member, a conductive layer of the conductive member comprises a matrix domain structure, at least a part of the domains Dt is exposed at the conductive member outer surface, the matrix has a volume resistivity R1 of larger than 1.00×1012 ?·cm, the domains Dt has a volume resistivity of smaller than R1, the developing device comprises the toner, domains Dc formed of the crystalline material exist in a cross section of the toner, distances between adjacent wall surfaces of the domains Dc is from 30 to 1,100 nm, and a weight-average particle diameter D4 of the toner and distances Dms between adjacent wall surfaces between the domains Dt satisfies D4?Dms.Type: ApplicationFiled: October 15, 2020Publication date: April 22, 2021Inventors: Yoshitaka Suzumura, Hiroyuki Tomono, Takuya Mizuguchi, Osamu Matsushita, Shunsuke Matsushita, Masahiro Kurachi, Kazuhiro Yamauchi
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Publication number: 20210080846Abstract: A toner comprising a toner particle including a binder resin, wherein in a temperature T (° C.)-storage elastic modulus G? (Pa) curve obtained by measuring the toner with a rheometer, a storage elastic modulus G? (80° C.) at 80° C. is from 2.0×103 Pa to 2.0×105 Pa; and a local minimum value of a change amount (dG?/dT) of a storage elastic modulus G? in a range of 60° C. to 80° C. with respect to a temperature T is ?1.0×106 or less, and when the temperature of the toner is raised, where a projected area of the toner at 80° C. is S1 (?m2), a radius of the projected area of the toner at 80° C. is R1 (?m), and a projected area of the toner at 120° C. is S2 (?m2), the S1, R1 and S2 satisfy a following formula (1): S2/S1×1/R1?0.22.Type: ApplicationFiled: September 4, 2020Publication date: March 18, 2021Inventors: Takuya Mizuguchi, Yoshitaka Suzumura, Hiroyuki Tomono, Osamu Matsushita, Shuntaro Watanabe, Hiroki Akiyama, Hiroki Kagawa
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Patent number: 10519213Abstract: Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.Type: GrantFiled: July 22, 2019Date of Patent: December 31, 2019Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, OCHSNER CLINIC FOUNDATION, NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Robert C. Gensure, Joshua Sakon, Osamu Matsushita, Tulasi Ponnapakkam
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Publication number: 20190376053Abstract: The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.Type: ApplicationFiled: February 9, 2018Publication date: December 12, 2019Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE KITASATO INSTITUTEInventors: Joshua SAKON, Jeffrey ROESER, Ryan BAUER, Katarzyna JANOWSKA, Keisuke TANAKA, Osamu MATSUSHITA, Kentaro UCHIDA
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Publication number: 20190338010Abstract: Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.Type: ApplicationFiled: July 22, 2019Publication date: November 7, 2019Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, OCHSNER CLINIC FOUNDATION, NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Robert C. Gensure, Joshua Sakon, Osamu Matsushita, Tulasi Ponnapakkam
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Publication number: 20190249163Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.Type: ApplicationFiled: February 22, 2019Publication date: August 15, 2019Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSA S, The Kitasato Institute, MONTEFIORE MEDICAL CENTER, NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERISTYInventors: Tulasi Ponnapakkam, Sagaya Theresa Leena Philominathan, Joshua Sakon, Ranjitha Katikaneni, Takaki Koide, Osamu Matsushita, Robert C. Gensure, Nozomu Nishi
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Patent number: 10358471Abstract: Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.Type: GrantFiled: January 16, 2019Date of Patent: July 23, 2019Assignees: The Board of Trustees of the University of Arkansas, Ochsner Clinic Foundation, National University Corporation Kagawa universityInventors: Robert C. Gensure, Joshua Sakon, Osamu Matsushita, Tulasi Ponnapakkam
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Publication number: 20190135890Abstract: Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.Type: ApplicationFiled: January 16, 2019Publication date: May 9, 2019Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, OCHSNER CLINIC FOUNDATION, NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Robert C. Gensure, Joshua Sakon, Osamu Matsushita, Tulasi Ponnapakkam
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Patent number: 10213488Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.Type: GrantFiled: December 21, 2016Date of Patent: February 26, 2019Assignees: The Board of Trustees of the University of Arkansas, The Kitasato Institute, Montefiore Medical CenterInventors: Tulasi Ponnapakkam, Sagaya Theresa Leena Philominathan, Joshua Sakon, Ranjitha Katikaneni, Takaki Koide, Osamu Matsushita, Robert C. Gensure
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Patent number: 10202434Abstract: Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.Type: GrantFiled: December 22, 2016Date of Patent: February 12, 2019Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, OCHSNER CLINIC FOUNDATION, NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITYInventors: Robert C. Gensure, Joshua Sakon, Osamu Matsushita, Tulasi Ponnapakkam
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Publication number: 20180140742Abstract: 1) A graft material for nerve regeneration characterizing by comprising collagen-based materials containing collagen having an orientation. 2) A method for producing a graft material for nerve regeneration comprising a step of immersing the collagen-based materials containing collagen having an orientation in a solution containing a collagen-binding site-containing growth factor comprising a receptor agonist peptide and a collagen-binding peptide and binding the collagen-binding site-containing growth factor to the collagen. 3) A kit for producing a graft material for nerve regeneration characterized by comprising collagen-based materials containing collagen having an orientation, and a collagen-binding site-containing growth factor comprising a receptor agonist peptide and a collagen-binding peptide.Type: ApplicationFiled: October 16, 2015Publication date: May 24, 2018Inventors: Kentaro UCHIDA, Gen INOUE, Hisako FUJIMAKI, Masashi TAKASO, Taro SAKU, Yoshihiro ISOBE, Osamu MATSUSHITA, Takehiko MIMA, Nozomu NISHI, Shunji HATTORI, Keisuke TANAKA, Takayuki OGURA